CAS: 59649-56-8; 2,3-Diaminophenol

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CAS号603-85-0 2-氨基-3-硝基苯酚 | CAS号66-56-8 2,3-二硝基苯酚 | CAS号767-66-8 Benzo[c][1,2,5]... | CAS号554-84-7 3-硝基苯酚 | CAS号64-17-5 乙醇 | CAS号67021-83-4 4-羟基苯并咪唑 | CAS号1039715-25-7 2-(三氟甲基)-6,11-二... | CAS号17056-99-4 5-羟基喹喔啉 | CAS号116345-46-1 N-(2-acetamido-... | CAS号767-67-9 1H-2,1,3-benzos... | CAS号862270-94-8 1,4-二氢-5-羟基-2,3... | CAS号475576-83-1 2,7,8-三氨基-4-(3-... | CAS号59649-58-0 3-furan-2-yl-qu... | CAS号59649-57-9 2-(furan-2-yl)-...

2-氨基-3-硝基苯酚置于palladium 10% On Activated Carbon,氢气体系中,用 甲醇 作为反应溶剂,化学反应 2.0H,反应生成 2,3-二氨基苯酚
参考文献:探索新型 2-苄基苯并咪唑类似物作为转录因子 Nf-Kb 抑制剂的 Sar
标题:探索新型 2-苄基苯并咪唑类似物作为转录因子 Nf-Kb 抑制剂的 Sar
摘要:设计,合成了一系列新的 2-苄基苯并咪唑类似物,并使用 Seap 测定研究了它们在 Raw 264.7 细胞中对 Lps 诱导的 Nf-Kb 抑制的体外活性.其中,4-((4-(环己基甲氧基)-1H-苯并[d]咪唑-2-基)甲基)苯酚(6E,在30 μm时抑制>100%,Ic50 = 3.0 μm),4-((5-(环己基甲氧基)-1H-苯并[d]咪唑-2-基)甲基)苯酚(6J,30 μm时抑制率为96%,Ic50 = 4.0 μm)和2-((4-(环己基甲氧基)-1H-苯并[D]Imidazol-2-yl)Methyl)Phenol(6K,在 30 μm 时抑制率为 95%,Ic50 = 5.0 μm)显示出很强的抑制活性.构效关系证实苯并咪唑环a上4或5位疏水性环己基甲氧基取代显着增强了活性.此外,苯环b上2或4位的亲水性氢键供体基团(Oh)与苯并咪唑环的一个亚甲基间隔基相连,有利于抑制活性.然而,苯环
DOI:10.1007/s12272-017-0886-1

专利信息

专利号:US-6251689-B1
优先权日:1998-05-14
标 题:Methods for the solid phase synthesis of combinatorial libraries of benzimidazoles benzoxazoles benzothiazoles and derivatives thereof
发明人：LABORDE EDGARDO; MATSUMOTO YUKIHARU
权利人:TELIK INC
摘要:The present invention provides an efficient and versatile method for the synthesis and screening of combinatorial libraries of benzimidazoles, benzoxazoles, benzothiazoles, and derivatives thereof. In order to expedite the synthesis of large arrays of compounds possessing these core structures, a general methodology for solid phase synthesis of these derivatives is provided. Arrays of benzimidazoles, benzoxazoles, benzothiazoles, and derivatives thereof useful as peptidomimetics and for the identification of agents having antifungal, antiviral, antimicrobial, anticoagulant, and antiulcer activity, or use in the treatment of inflammation, hypertension, cancer, and other conditions can be prepared by this method.

专利号:US-6051704-A
优先权日:1996-07-22
标题:Synthesis of macrocyclic tetraamido-N ligands
发明人：GORDON-WYLIE SCOTT W; COLLINS TERRENCE J
权利人:UNIV CARNEGIE MELLON
摘要:New synthetic methods for the preparation of macrocyclic amido-N donor ligands are provided. The primary method of the present invention involves in general only two synthetic steps. In the first step, an α or β amino carboxylic acid is allowed to react with an optimal (approximately stoichiometric) amount of an activated malonate or oxalate derivative with mild heating. Upon completion of the double coupling reaction, hydrolysis of the reaction mixture yields a diamide containing intermediate (a macro linker). In the second step, stoichiometric amounts of a diamine, preferably an orthophenylene diamine, are added to the macro linker intermediate in the presence of a coupling agent and heat. This second double coupling reaction, is allowed to proceed for a period of time sufficient to produce a macrocyclic tetraamido compound. The substituent groups on the α or β amino carboxylic acid, the malonate, and the aryl diamine may all be selectively varied so that the resulting tetraamido macrocycle can be tailored to specific desired end uses. The macrocyclic tetraamide ligand may then be complexed with a metal, such as a transition metal, and preferably the middle and later transition metals, to form a robust chelate complex suitable for catalyzing oxidation reactions.

专利号:US-6011152-A
优先权日:1996-07-22
标 题 :Synthesis of macrocyclic tetraamido-N ligands

专利号:US-5191088-A
优先权日:1991-03-11
标题 :Aromatic monoanhydride-esters
发明人：BLYAKHMAN YEFIM
权利人:CIBA GEIGY CORP
摘要:Aromatic monoanhydride-esters of the formula (I) ##STR1## wherein R 1 is ##STR2## and R 2 is hydrogen, C 1 -C 4 alkyl or --OCH 3 are useful as endcapping agents for the synthesis of multifunctional high temperature resins such as polyimides, polyimide-esters, polyimide-ethers and polyimide-amides.

专利号:EP-0504109-A1
优先权日:1991-03-11
标题:Aromatic monoanhydride-esters
发明人：BLYAKHMAN YEFIM
权利人:CIBA GEIGY AG
摘要:Aromatic monoanhydride-esters of the formula (I)n n wherein R¹ isn n and R² is hydrogen, Câ‚?-Câ‚„alkyl or -OCH₃ are useful as endcapping agents for the synthesis of multifunctional high temperature resins such as polyimides, polyimide-esters, polyimide-ethers and polyimide-amides.

专利号:WO-2004076425-A1
优先权日:2003-02-21
标题:Improved synthesis of macrocyclic tetraamido compounds and new metal insertion process