CAS: 5965-66-2; (2R,3R,4R,5S,6R)-6-(Hydroxymethyl)-5-(((2S,3R,4S,5R,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Tetrahydro-2H-Pyran-2,3,4-Triol

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CAS号64-18-6 甲酸 | CAS号849585-22-4 2-羟基丙酸

2-(三甲基硅烷基)乙基乳糖苷置于三氟乙酸体系中,用 二氯甲烷 作为反应溶剂,化学反应 0.5H,以95%的收率获得产物β-乳糖
参考文献:2-Trimethylsilylethyl Glycosides. Anomeric Deblocking Of Mono-And Disaccharides.
标题:2-Trimethylsilylethyl Glycosides. Anomeric Deblocking Of Mono-And Disaccharides.
摘要:
DOI:10.1016/s0040-4039(00)80096-9

专利信息

专利号:WO-0142264-A1
优先权日:1999-12-10
标 题 :Method for the synthesis of sialylated oligosaccharide donors
发明人：MEHTA SEEMA; GILBERT MICHEL; WAKARCHUK WARREN W; WHITFIELD DENNIS M
权利人:CA NAT RESEARCH COUNCIL; MEHTA SEEMA; GILBERT MICHEL; WAKARCHUK WARREN W; WHITFIELD DENNIS M
摘要:A method for the synthesis of aryl thioglycosides comprising a sialylated residue of β-D-galactose is disclosed. The method consists of preparing by a chemical synthesis a non-sialylated aryl thioglycoside, and enzymatically sialylating the latter with a sialic acid in the presence of a suitable sialyltransferase. The sialylated aryl thioglycoside is then chemically derivatized by standard procedures, to provide a derivative suitable for use as a donor in chemical syntheses of sialylated oligosaccharides. The derivatized sialylated aryl thioglycosides are prepared in high yields, due to reduced number of chemical and purification steps involved in the process. Derivatized aryl thioglycosides useful as building blocks for the synthesis of biologically active sialylated oligosaccharides are also disclosed.

专利号:US-5374541-A
优先权日:1993-05-04
标 题 :Combined use of β-galactosidase and sialyltransferase coupled with in situ regeneration of CMP-sialic acid for one pot synthesis of oligosaccharides
发明人：WONG CHI-HUEY; GAETA FEDERICO C A
权利人:SCRIPPS RESEARCH INST; CYTEL CORP
摘要:A single reaction vessel process for the synthesis of a sialylated galactoside is disclosed. The synthesis utilizes a β-galactosidase to catalyze the reaction of a galactose-containing substrate and an acceptor to form a new galactosyl glycoside that is then sialylated using a cyclic multienzyme synthesis system to form CMP-sialic acid that sialylates the formed galactosyl glycoside in the presence of an α-sialyltransferase. The value of K m /V max for the formed galactosyl glycoside as a substrate for the α-sialyltransferase is less than one-third the K m /V max value for the galactose-containing substrate for that α-sialyltransferase.

专利号:US-5532147-A
优先权日:1991-08-06
标题:Enzymatic method for synthesis of carbohydrates
发明人：NILSSON KURT
摘要:A synthetic method in which is included at least one process, which is characterized by that a glycosidase (EC 3.2) is used to catalyse a reaction between a partially protected galactose derivative, or a partially protected glucose derivative, and a glycosyl doner, which is an oligosaccharide or a monosaccharide glycoside, is described. The process is suitable for synthesis of carbohydrate derivatives or for synthesis of partially protected carbohydrate intermediates which are suitable for further synthesis e.g. of blood group determinants A and B, or other carbohydrates.

专利号:WO-9518232-A1
优先权日:1993-12-24
标题 :Enzymatic method for synthesis of o-glycosylated amino acid or peptide or derivatives thereof
发明人：NILSSON KURT
权利人:NILSSON KURT
摘要:Present invention describes a method for synthesis of O-glycosylated amino acid or peptide or derivatives thereof, characterized by the use of a glycosyl donor which is a monosaccharide in pyranose or furanose form or which is an oligosaccharide, and by the use of an acceptor which is a hydroxyl group containing amino acid or peptide derivative which has been modified in its N-terminal α-amino group and in which the C-terminal carboxyl group is non-modified, employing an exo- or an endoglycosidase (EC 3.2) as catalyst in an equilibrium reaction and that the product is isolated from the reaction mixture or is used directly or after partial or complete isolation in a continued synthesis with chemical methods or with enzymatic methods.

专利号:US-9034844-B2
优先权日:2009-04-06
标 题 :6′-sialyllactose salts and process for their synthesis and for the synthesis of other alpha-sialyloligosaccharides
发明人：TAMERLANI GIANCARLO; LOMBARDI ILARIA; BARTALUCCI DEBORA; DANESI ANDREA; SALSINI LIANA; MANONI MARCO; CIPOLLETTI GIOVANNI
权利人:TAMERLANI GIANCARLO; LOMBARDI ILARIA; BARTALUCCI DEBORA; DANESI ANDREA; SALSINI LIANA; MANONI MARCO; CIPOLLETTI GIOVANNI; INALCO SPA
摘要:The present invention relates to a process of synthesis of α-sialyl oligosaccharides and in particular of 6′-sialyllactose and its salts comprising a step of coupling by Koenigs-Knorr reaction under conditions that allow its use on an industrial scale.

专利号:US-9433605-B2
优先权日:2006-03-23
标 题 :Method for promoting synthesis of tissue collagen
发明人：KAMIYA TOSHIKAZU; KAMIMURA AYAKO; KAWADA YOKO
权利人:KYOWA HAKKO BIO CO LTD
摘要:An object of the present invention is to provide an oral preparation for promoting synthesis of tissue collagen, an oral preparation for promoting healing of skin wounds or an oral preparation for preventing or improving skin wrinkles or sagging, which is safe and has an excellent effect. The present invention can provide an oral preparation for promoting synthesis of tissue collagen, an oral preparation for promoting healing of skin wounds or an oral preparation for preventing or improving skin wrinkles or sagging, which comprises hydroxyproline or a salt thereof as an active ingredient.