CAS: 626-40-4; 3,5-Dibromoaniline

该化合物是一种溴化芳烃,含有分子式C6H5BR2N.该化合物的特征是,在Anline环的3和5个位置上有两个溴替代物,这增强了其在有机合成中的活性和实用性;它是制作药品,农用化学品和特殊染料的宝贵中间媒介;溴原子通过交叉反应,如Suzuki或Buchwald-Hartwig交错,促进进一步功能化,使其成为复杂分子框架的多功能建筑块;其高纯度和稳定性在标准条件下确保了合成应用的一贯性;建议适当处理,因为其潜在毒性以及对光和湿度的敏感性.

英文名称3,5-Dibromoaniline
中文名称3,5-二溴苯胺
IUPAC名称3,5-dibromoaniline
其它别名3,5-Dibromoaniline
CAS编号626-40-4
MFCD编号:MFCD00047841
EINECS号:640-157-8
分子式:C6H5Br2N
分子量:250.92
产品CID: 1607836
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: RVNUUWJGSOHMRR-UHFFFAOYSA-N
InChI=1S/C6H5Br2N/c7-4-1-5(8)3-6(9)2-4/h1-3H,9H2…
计算化学: 氢键受体数1.0氢键供体数1可旋转键数0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
急性毒性类别3(吸入)
急性毒性类别3(经皮)
急性毒性类别4(经口)
水生慢性毒性类别3
急性毒性类别4(吸入)
急性毒性类别4(经皮)
严重眼刺激类别2A
警示词Warning(警告)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H331 |吸入会中毒.
H311 |皮肤接触会中毒.
H302 |吞咽有害.
H412 |对水生生物有害并具有长期持续影响.
H332 |吸入有害.
H312 |皮肤接触有害.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险品标志Xi

欧盟法规

ECHA物质C&L通报

上下游产品

合成工艺路线路线简述

合成目标产物 3,5-Dibromoaniline 主要起始原料 2,6-Dibromo-4-Nitroaniline
(文献来源)合成步骤主要原料 2,6-Dibromo-4-Nitroaniline

1,2-二硝基苯置于盐酸,Tin,Ammonium Sulfide体系中,化学反应生成 3,5-二溴苯胺
参考文献:Koerner,Gazzetta Chimica Italiana,1874,Vol. 4,P. 341
标题:Koerner,Gazzetta Chimica Italiana,1874,Vol. 4,P. 341

专利信息

专利号:WO-2010139090-A1
优先权日:2009-06-02
标题 :N-phenyl dichloroacetamide and their derivatives, preparation methods and uses theirof
发明人：CHENG CHANGMEI; YANG YONGCHONG; CHANG ZHIJIE; CHEN ZHESHENG; ZHANG FENG; WANG DONGCHUN; LU AIJUN
权利人:UNIV TSINGHUA; CHENG CHANGMEI; YANG YONGCHONG; CHANG ZHIJIE; CHEN ZHESHENG; ZHANG FENG; WANG DONGCHUN; LU AIJUN
摘要:N-Phenyl dichloroacetamide and their derivatives which belong to pharmaceutical chemistry and organic synthesis fields are provided. These compounds have the structures of general formula I, in which N-{3-chloro-4-[(trifluoromethyl)sulfonyl]phenyl}dichloroacetamide is preferred. The preparation methods of these compounds are also provided, which are easy to conduct. There is no need to use any catalyst in these methods. Additionally, the uses of these compounds in the preparation of anticancer drugs which have high-effective and low toxic anticancer activities are provided.

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优先权日:2022-05-17
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专利号:CN-114907416-A
优先权日:2022-05-17
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优先权日:2010-03-31
标题 :Synthesis method of isatin derivatives

专利号:CN-112457243-B
优先权日:2020-11-20
标题 :Synthesis method of 7-bromo-5-methoxyquinoline