CAS: 7682-20-4; H-Abu-Nh2 Hcl

相似化合物

7324-11-0 89603-48-5 103765-03-3

上下游产品

2-aminobutyronitrile (+/-)-2-((benzylidene)amino)butanamide α-aminobutyramide hydrobromide tert-butyl N-[(1S)-1-carbamoylpropyl]carbamate2B°C-Tyr-Abu-NH2

(S)-2-氨基丁酸甲酯置于氨,盐酸体系中,用 异丙醇 作为反应溶剂,化学反应 37.0H,以92.8%的收率获得产物(S)-(+)-2-氨基丁酰胺盐酸盐
参考文献:一种左乙拉西坦关键中间体(S)-2-氨基丁酰 胺盐的制备方法
标题:一种左乙拉西坦关键中间体(S)-2-氨基丁酰 胺盐的制备方法
摘要:本发明公开了一种左乙拉西坦关键中间体(S)‑2‑氨基丁酰胺盐的制备方法,属于药物中间体合成技术领域.本发明的制备方法是将化合物1在c1~c3烷基醇中发生氨解反应,反应完毕后减压浓缩至干,加入醇类溶剂进一步通入氨气游离,过滤浓缩后加入醇类溶剂溶清,滴加酸的醇类溶剂成盐后养晶,制备纯化得到化合物2,其中x为盐酸,氢溴酸或甲磺酸.本发明所述的制备方法简便有效,收率和纯度大大提高,其中摩尔收率大于90%,纯度大于99.5%,为后续左乙拉西坦的制备提供了高质量的中间体,该制备方法没有手性拆分的步骤,溶剂单一,回收简单,三废较少,符合工业化生产的要求.

专利信息

专利号:US-2023183177-A1
优先权日:2020-04-24
标题:Enantioselective chemo-enzymatic synthesis of optically active amino amide compounds
发明人：GRILL BIRGIT; WINKLER MARGIT; SCHWAB HELMUT; STROHMEIER GERNOT; DONSBACH KAI; WALDVOGEL SIEGFRIED R; ARNDT SEBASTIAN; WEIS DOMINIK
权利人:PHARMAZELL GMBH
摘要:The present invention relates to a novel biocatalytic process for the stereoselective preparation of alpha amino amide compounds catalyzed by NHase enzymes. A further aspect of the invention relates to novel NHase enzymes as well as further improved NHase enzyme mutants, nucleic acid molecules encoding these enzymes, recombinant microorganisms suitable for preparing such enzymes and mutants. Another aspect of the invention relates to a chemo-biocatalytic process for the preparation of lactam compounds comprising the new catalytic process for the preparation of alpha amino amide compounds catalyzed by NHase enzymes, as well as the chemical oxidation of the alpha amino amide by applying certain chemical oxidation catalysts suitable for converting the alpha amino amide under retention of its stereochemical configuration to the respective lactam. The novel chemo-biocatalytic process is particularly suited for the synthesis of valuable pharmaceutical compounds, like in particular (S)-Levetiracetam.

专利号:US-2022064111-A1
优先权日:2019-01-17
标 题:Enantioselective synthesis of brivaracetam and intermediates thereof
发明人：ROY SARABINDU; GHOSH ANGSHUMAN; KUBEER RAMESH DHONDI; PRASAD MUTYALA V V VARA; PAUL GOPAL; GARAI ABHISHEK; CHAKRABORTY SOURAV; HALDAR ANIMESH; YADAW AJAY KUMAR; ROY SUBHO
权利人:CLININVENT RES PVT LTD
摘要:The present invention relates to an improved and economical process for enantioselective synthesis and purification of a novel key intermediate of Brivaracetam. Further, the present invention also relates to a process for the preparation of a chirally pure Brivaracetam of formula I utilizing the said intermediate.

专利号:US-2024343689-A1
优先权日:2021-08-16
标题:Synthesis of brivaracetam
发明人：REDDY DESIREDDY SRINIVASA; REDDY PEKETI SUBBA; REDDY VEDURURI MADHAVA
权利人:OPTIMUS DRUGS PRIVATE LTD
摘要:The present invention relates to a novel compound of(S)-2-((Z)-((R)-4-propyldihydrofuran-2(3H)-ylidene)amino) butanamide and an improved, commercially viable process for preparation of Brivaracetam using(S)-2-((Z)-((R)-4-propyldihydrofur an-2(3H)-ylidene)amino)butanamide.

专利号:EP-2524910-A1
优先权日:2011-05-17
标题 :Process for the resolution of aminobutyramide
发明人：BOESTEN WILHELMUS HUBERTUS JOSEPH; BOONEN JOZEF JOHANNES CATHERINA JACOBUS; WOESTENBORGHS PIERRE LOUIS
权利人:DSM IP ASSETS BV
摘要:The present invention relates to a process for the resolution of Schiff bases of racemic ( R,S )-2-aminobutyramide to give optically pure ( S )-2-aminobutyramide, an intermediate in the synthesis of levetiracetam.

专利号:WO-2023021363-A1
优先权日:2021-08-16
标 题:Synthesis of brivaracetam

专利号:US-12221413-B2
优先权日:2015-05-25
标 题:Processes to produce brivaracetam
发明人：WANG PENG; LI PIXU; WEI QIANG; LIU YUANHUA
权利人:SUZHOU PENGXU PHARMATECH CO LTD
摘要:The present invention provides a scalable synthesis of enantiomerically pure brivaracetam, and related derivatives.