专利号:US-9506095-B2 优先权日:2012-02-09 标 题:Process for the enzymatic synthesis of (7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid or esters thereof, and application in the synthesis of ivabradine and salts thereof 发明人:PEDRAGOSA-MOREAU SANDRINE; LEFOULON FRANÇOIS 权利人:SERVIER LAB; LES LABORATORIES SERVIER 摘要:Process for the enzymatic synthesis of the compound of formula (I): n nwherein R 1 represents a hydrogen atom or an alkyl group.n n Application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.
专利号:US-9476071-B2 优先权日:2013-02-28 标 题 :Process for the enzymatic synthesis of (7S)-3,4-dimethoxybicyclo[4.2.0]OCTA-1,3,5-triene-7-carboxylic acid and application in the synthesis of ivabradine and salts thereof 发明人:PEDRAGOSA-MOREAU SANDRINE; LEFOULON FRANÇOIS 权利人:SERVIER LAB 摘要:Process for the enzymatic synthesis of the compound of formula (I): n ncomprising enantioselective enzymatic hydrolysis of the nitrile of formula (IV):n n nusing the nitrilase of Rhodococcus rhodochrous of EMBL accession number EF467367.1, and the application of such a process in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.
专利号:US-4000169-A 优先权日:1975-01-27 标题 :Asymmetric synthesis of optically active compounds 发明人:CHAN KA-KONG; SAUCY GABRIEL 权利人:HOFFMANN LA ROCHE 摘要:Asymmetric synthesis of optically active 3,7,11-trimethyl-dodecan-1-ol, an intermediate for producing optically active vitamin E, from isovaleraldehyde or prenal including intermediates in this synthesis.
专利号:US-6610855-B2 优先权日:1999-03-22 标题:Synthesis of 3-amino-3-aryl propanoates 发明人:ABDEL-MAGID AHMED F; COHEN JUDITH H; MARYANOFF CYNTHIA A; VILLANI JR FRANK JOHN; ZHONG HUA M 权利人:MCNEIL PHARMACEUTICAL INC 摘要:A process for the synthesis of a compound of the formulawherein R1 is aryl, heteroaryl, substituted aryl or substituted heteroaryl and R2 is hydrogen, alkyl or aralkyl, or salt thereof.
专利号:US-10239836-B2 优先权日:2014-10-01 标题 :Benzenecarbothioccyclopenta[c] pyrrole-1,3-dione compounds and process for synthesis thereof 发明人:REDDY DUMBALA S; PHILKHANA SATISH C; JACHAK GORAKHNATH R; GUNJAL VIDYA B 权利人:COUNCIL SCIENT IND RES 摘要:The present invention provides a novel process for synthesis of nitrosporeusines A(1) and B(2). More particularly, the present invention provides a synthetic route for synthesis of nitrosporeusines A(1) and B(2). Said process is simple, industrially scalable, cost effective and eco-friendly.
专利号:US-4160865-A 优先权日:1975-01-27 标题:Asymmetric synthesis 发明人:CHAN KA-KONG; SAUCY GABRIEL 权利人:HOFFMANN LA ROCHE 摘要:Asymmetric synthesis of optically active 3,7,11-trimethyl-dodecan-1-ol, an intermediate for producing optically active vitamin E, from isovaleraldehyde or prenal including intermediates in this synthesis.