CAS: 95058-81-4; 4-Amino-1-((2R,4R,5R)-3,3-Difluoro-4-Hydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-yl)Pyrimidin-2(1H)-One

相似化合物

122111-03-9 10212-20-1 701937-51-1

上下游产品

CAS号122111-03-9 盐酸吉西他滨 | CAS号1260238-57-0 2'-deoxy-2',2'-... | CAS号103882-84-4 吉西他滨 | CAS号861445-90-1 ((2R,3R)-3-acet... | CAS号892128-60-8 LY2334737 | CAS号116371-67-6 吉西他滨单磷酸酯 | CAS号122111-03-9 盐酸吉西他滨 | CAS号95058-85-8 α-gemcitabine

盐酸吉西他滨置于potassium Carbonate体系中,用 乙醇,二氯甲烷 作为反应溶剂,化学反应生成 吉西他滨
参考文献: Pharmaceutical Composition Comprising Gemcitabine And Cyclodextrines[fr] Preparations Pharmaceutiques Comprenant De La Gemcitabine Et De La Cyclodextrine
标题: Pharmaceutical Composition Comprising Gemcitabine And Cyclodextrines[fr] Preparations Pharmaceutiques Comprenant De La Gemcitabine Et De La Cyclodextrine
摘要:本发明提供一种包含吉西他滨和环糊精的药物组合物.该药物配方适用于液体静脉给药.

专利信息

专利号:US-2015182634-A1
优先权日:2012-12-28
标 题:Molecular Design and Chemical Synthesis of Pharmaceutical-Ligands and Pharmaceutical-Pharmaceutical Analogs with Multiple Mechanisms of Action
发明人：COYNE CODY P; BEAR RYAN; JONES TONI
权利人:COYNE CODY P; BEAR RYAN; JONES TONI
摘要:Multi-phase and single-phase chemical reaction schemes have been developed for the synthesis of pharmaceutical-ligand analogs, pharmaceutical-pharmaceutical analogs, and similar molecular-molecular analogs that possess multiple mechanisms of action. The multi-phase organic chemical reaction schemes include relatively mild reaction conditions, high end product yields, and comparatively rapid completion of chemical reactions, which are all of particular utility for the synthesis of preparations including covalent pharmaceutical-receptor ligand or pharmaceutical-immunoglobulin analogs. Examples of pharmaceutical-ligand preparations that can be synthesized utilizing the multi-step chemical reaction schemes include covalent chemotherapeutic-ligand agents that possess selective targeted delivery properties and a capacity to exert additive and synergistic levels of cytotoxic anti-neoplastic potency. Pharmaceutical-pharmaceutical analogs, including chemotherapeutic-chemotherapeutic analogs that are capable of exerting multiple mechanisms of action, can be synthesized using either of the described multi-phase or single-phase organic chemistry reaction schemes. Each of these representative examples has utility against a spectrum of disease states including, for example, neoplastic conditions such as mammary adenocarcinoma/carcinoma, ovarian carcinoma, prostatic carcinoma, intestinal carcinoma, melanoma, leukemia, myeloma, and lymphoma.

专利号:US-2007042987-A1
优先权日:2004-07-30
标题:Stereoselective synthesis of beta-nucleosides
发明人：LIN KO-CHUNG; LI WENSEN; LIN CHUNHUI; YUNGSHUN WEIN; KUO-HIS KAO
权利人:LIN KO-CHUNG; LI WENSEN; LIN CHUNHUI; YUNGSHUN WEIN; KUO-HIS KAO
摘要:This invention relates to a process of stereoselectively synthesizing an alcohol of the following formula: n n nwherein R 1 , R 2 , R 3 , R 4 , and R 5 are defined in the specification. The process includes reacting (R) 4-formyl-2,2-dimethyldioxolane with α-bromoacetate in the presence of Zn and a Zn activating agent.

专利号:US-7485716-B2
优先权日:2005-05-02
标题:Stereoselective synthesis of β-nucleosides
发明人：LIN KO-CHUNG; LI WENSEN
权利人:PHARMAESSENTIA CORP
摘要:This invention relates to a process for stereoselectively preparing a nucleoside of the following formula: n nwherein R 3 , R 4 , and B are defined herein. The process includes reacting a furanose compound with a nucleobase in the presence of a halide salt. Also disclosed is another process for stereoselectively synthesizing an intermediate that can be used to make the starting compound in the first-mentioned process.

专利号:US-2007015914-A1
优先权日:2005-05-02
标 题:Stereoselective synthesis of beta-nucleosides

专利号:US-11040997-B2
优先权日:2012-11-16
标 题:Process for preparing nucleoside prodrugs
发明人：MCGUIGAN CHRISTOPHER; PERTUSATI FABRIZIO
权利人:NuCana plc
摘要:Provided are phosphoramidate nucleoside compounds of Formula (I), or pharmaceutically acceptable salts or esters or solvates thereof, useful in the treatment of cancer, viral infections and other diseases: n nAlso provided is a process for the synthesis of compounds of Formula (I) where a desired enantiomer, having regard to the asymmetric chiral center of the phosphorus atom P, is provided in an enriched amount. The process comprises admixing a nucleoside with a phosphorochloridate in the presence of a catalyst comprising a metal salt selected from the group consisting of salts of Cu, Fe, La and Yb.