3-溴吡啶置于盐酸,正丁基锂体系中,用 正己烷,水,甲苯 用作溶剂,化学反应 0.03H,反应生成3-吡啶硼酸 参考文献:A Polyfluorene Based Zwitterionic Fluorescent Probe For Response Towards Biological Species In Aqueous Media 标题:A Polyfluorene Based Zwitterionic Fluorescent Probe For Response Towards Biological Species In Aqueous Media 摘要:水溶性,含硼酸基团的聚芴已经合成,用于检测含有二醇的生物分子,在ph 7.4时通过有效的荧光"关闭". Doi:10.1039/c4Nj00448E
专利号:WO-2021019559-A1 优先权日:2019-07-30 标题 :Synthesis of 5-(3-pyridyl)-2,2'-bithiophene(sensitizer) 发明人:DATLA ANUPAMA; NAGRE PRASHANT; TAMORE JAGDISH; PRABHU MANOJKUMAR SADANAND; KADAM SACHIN VASANT 权利人:FERMENTA BIOTECH LTD 摘要:Disclosed herein is a novel simple, short process for synthesis of the photosensitizer, 5-(3-pyridyl)-2,2'-bithiophene.
专利号:WO-2024018354-A1 优先权日:2022-07-18 标题 :A process for the synthesis of 4-alkoxy-3-hydroxypicolinic acids and intermediates thereof 发明人:MAL SANJIB; SARKAR PARANTAP; PATRA PRANAB KUMAR; KLAUSENER ALEXANDER GUENTHER MARIA 权利人:PI INDUSTRIES LTD 摘要:The present invention discloses a process for the synthesis of 4- alkoxy-3-hydroxypicolinic acids of formula (I) from 2-picolinic acid. The present invention further discloses a process for preparation of compounds of formula (iii) from compounds of formula (ii). The present invention also discloses novel intermediate compounds of formula (iii).
专利号:US-12275733-B2 优先权日:2016-11-07 标 题:Substituted pyrido[3,4-b]indoles for the treatment of cartilage disorders 发明人:GRETZKE DIRK; RITZELER OLAF; HEINELT UWE; WEHNER VOLKMAR; SCHMIDT FRIEDEMANN 权利人:SANOFI SA 摘要:The present invention relates to 8-aryl-substituted and 8-heteroaryl-substituted 9H-pyrido[3,4-b]indoles of the formula (I), in which A, E, G, R1 to R6 and R10 are as defined in the claims, which stimulate chondrogenesis and cartilage matrix synthesis and can be used in the treatment of cartilage disorders and conditions in which a regeneration of damaged cartilage is desired, for example joint diseases such as osteoarthritis. The invention furthermore relates to processes for the synthesis of the compounds of the formula (I), their use as pharmaceuticals, and pharmaceutical compositions comprising them.
专利号:US-8188113-B2 优先权日:2006-09-14 标 题 :Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases 发明人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C 权利人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C; DECIPHERA PHARMACEUTICALS INC 摘要:The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.
专利号:US-10927095-B2 优先权日:2017-08-14 标 题:Processes for the preparation of Niraparib and intermediates thereof 发明人:LUTHRA PARVEN K; VASOYA SANJAY L; PATIL BHATU T; TANEJA AMIT K; SRIVASTAV NAVEEN C; SINGH RINKU 权利人:TEVA PHARMACEUTICALS INT GMBH 摘要:The present invention relates to novel procedures and novel intermediates useful in the synthesis of Niraparib or any salt thereof.
专利号:US-2012328569-A1 优先权日:2010-03-02 标题:Inhibitors of hepatitis c virus ns5b polymerase 发明人:MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; SOLL RICHARD; LI PENG; PENG XUANJIA; WU HAO; NARJES FRANK; HABERMANN JOERG; KOCH UWE; LIU SHILAN 权利人:MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; SOLL RICHARD; LI PENG; PENG XUANJIA; WU HAO; NARJES FRANK; HABERMANN JOERG; KOCH UWE; LIU SHILAN 摘要:Disclosed are compounds of formula (I) that are used as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
参考标题:Synthesis Of A Novel Library Of 1-Substituted Pyrido[1,2-A]Benzimidazoles 作者:Satyanarayana Gadde,Yun Cheuk Leung,Mohan Bhadbade,Belamy B. Cheung,David Stc. Black,Naresh Kumar 摘要:The Reactivity And Synthesis Of New Analogues Of Pyrido[1,2-A]Benzimidazoles Have Been Explored. Twenty-Three Derivatives Bearing Phenoxy, Thiophenoxy, Aniline, And Aryl Groups At The 1-Position Were Successfully Synthesised In 25-91 % Yield, Via Nucleophilic Substitution, Buchwald-Hartwig Amination, And Suzuki Coupling Type Processes. Solvent Free Synthetic Protocols Were Employed To Achieve The Nucleophilic
合成参考文献
摘要:Mérour, J.-Y.; Joseph, B., Science of Synthesis Knowledge Updates, (2016) 3, 263. 摘要:Mérour, J.-Y.; Joseph, B., Science of Synthesis Knowledge Updates, (2016) 3, 399. 摘要:Götzinger, A. C.; Müller, T. J. J., Science of Synthesis Knowledge Updates, (2017) 3, 197. 摘要:Sainsbury, M., Science of Synthesis Knowledge Updates, (2010) 1, 234. 摘要:Spitzner, D., Science of Synthesis Knowledge Updates, (2016) 1, 193.