CAS: 19056-40-7; 4-Bromo-3-Methoxyaniline

上下游产品

CAS号77337-82-7 2-溴-5-硝基苯甲醚 | CAS号536-90-3 间氨基苯甲醚 | CAS号578-57-4 邻溴苯甲醚 | CAS号7439-89-6 铁粉 | CAS号38603-09-7 1,3-二溴-2-甲基苯 | CAS号7647-01-0 盐酸 | CAS号861298-97-7 2-acetylamino-5... | CAS号755027-18-0 2-溴-5-碘苯甲醚 | CAS号173312-36-2 4-溴-5-甲氧基-2-硝基苯胺 | CAS号55120-56-4 2-溴-5-氨基苯酚

间氨基苯甲醚置于n-溴代丁二酰亚胺(Nbs)体系中,用 乙腈 用作溶剂,以47%的收率获得4-溴-3-甲氧基苯胺
参考文献:Synthesis Of Arylbromides From Arenes And N-Bromosuccinimide (Nbs) In Acetonitrile-A Convenient Method For Aromatic Bromination
标题:Synthesis Of Arylbromides From Arenes And N-Bromosuccinimide (Nbs) In Acetonitrile-A Convenient Method For Aromatic Bromination
摘要:利用乙腈中的 N-溴代丁二酰亚胺(nbs),可以很容易地对一系列活化的炔类化合物进行区域选择性和化学选择性亲电溴化反应.与其他亲电溴化条件相比,该方法的环境友好,底物范围大且易于合成,从而提高了其实用性.
Doi:10.1139/v08-176

专利信息

专利号:BR-112016017679-B1
优先权日:2014-02-21
标题 :5-BENZYLISOQUINOLINE DERIVATIVE COMPOUNDS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES, PROCESS FOR THE SYNTHESIS OF SUCH COMPOUNDS AND PHARMACEUTICAL COMPOSITION CONTAINING THEM

专利号:US-7579356-B2
优先权日:2005-05-04
标 题:Thia-tetraazaacenaphthylene kinase inhibitors
发明人：BATTISTA KATHLEEN A; BIGNAN GILLES C; CONNOLLY PETER J; HAYDEN STUART; JOHNSON SIGMOND G; LIN RONGHUI; PANDEY NIRANJAN B; POWELL MARK T
权利人:JANSSEN PHARMACEUTICA NV
摘要:The present invention is directed to novel thia-tetraazaacenaphthylene compounds of Formula (I): n nand pharmaceutically acceptable forms thereof and their synthesis and use as inhibitors of ATP-protein kinase interactions.

专利号:US-8591878-B2
优先权日:2008-02-25
标 题:Therapeutic compounds
发明人：MCCAULEY JOHN A; LIVERTON NIGEL J; HARPER STEVEN; MCINTYRE CHARLES J; RUDD MICHAEL T
权利人:MCCAULEY JOHN A; LIVERTON NIGEL J; HARPER STEVEN; MCINTYRE CHARLES J; RUDD MICHAEL T; MERCK SHARP & DOHME; ANGELETTI P IST RICHERCHE BIO
摘要:A class of macrocyclic compounds of formula (I), wherein R 1 , R 3 , R 4 , R a , R b , A, B, Z, M, W and n are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Also provided are processes for the synthesis and use of such macrocyclic compounds for treating or preventing HCV infection.

专利号:US-8309540-B2
优先权日:2006-10-24
标 题:HCV NS3 protease inhibitors
发明人：LIVERTON NIGEL J; VACCA JOSEPH P; MCCAULEY JOHN A; ROMANO JOSEPH J; RUDD MICHAEL T
权利人:LIVERTON NIGEL J; VACCA JOSEPH P; MCCAULEY JOHN A; ROMANO JOSEPH J; RUDD MICHAEL T; MERCK SHARP & DOHME
摘要:The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections. (I)

专利号:US-8927569-B2
优先权日:2007-07-19
标 题 :Macrocyclic compounds as antiviral agents
发明人：HARPER STEVEN; SUMMA VINCENZO; LIVERTON NIGEL J; MCCAULEY JOHN A; BUTCHER JOHN W; DI FILIPPO MARCELLO; DI FRANCESCO MARIA EMILIA; FERRARA MARCO; ROMANO JOSEPH J; RUDD MICHAEL T
权利人:HARPER STEVEN; SUMMA VINCENZO; LIVERTON NIGEL J; MCCAULEY JOHN A; BUTCHER JOHN W; DI FILIPPO MARCELLO; DI FRANCESCO MARIA EMILIA; FERRARA MARCO; ROMANO JOSEPH J; RUDD MICHAEL T; MERCK SHARP & DOHME
摘要:A class of macrocyclic compounds of formula (I), wherein R 1 , R 3 , R 4 , R a , R b , A, Z, Y, X, M, W, n and m are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Also provided are processes 5 for the synthesis and use of such macrocyclic compounds for treating or preventing HCV infection. Formula (I):

专利号:US-7879797-B2
优先权日:2005-05-02
标 题 :HCV NS3 protease inhibitors
发明人：HOLLOWAY M KATHARINE; LIVERTON NIGEL J; LUDMERER STEVEN W; MCCAULEY JOHN A; OLSEN DAVID; RUDD MICHAEL T; VACCA JOSEPH P
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.