CAS: 59020-85-8; S-(Furan-2-Ylmethyl) Propanethioate

相似化合物

58066-86-7 1883-78-9 13678-68-7

上下游产品

2-thiolomethyl-furan propionyl chloride propionic acid anhydride

糠基硫醇,丙酸酐置于sodium Hydroxide体系中,用 水 作为反应溶剂,化学反应 0.5H,以32.4 Kg的收率获得产物硫代丙酸糠酯
参考文献:一种硫代丙酸糠酯的生产方法
标题:一种硫代丙酸糠酯的生产方法
摘要:本发明公开了一种硫代丙酸糠酯的生产方法,以糠醇为起始原料,经三步反应操作制得硫代丙酸糠酯,先由糠醇,硫脲,盐酸,水,氢氧化钠制取糠基硫醇;再由氢氧化钠,水,糠基硫醇制取糠硫醇钠.再由糠硫醇钠中滴加丙酸酐制取硫代丙酸糠酯.本发明安全环保,工艺操作简单易行,成品含量高,原料易得,生产成本低,适合大规模生产.

专利信息

专利号:US-4895939-A
优先权日:1986-02-24
标题:High percentage β-yield synthesis of carbapenem intermediates
发明人：MARTEL ALAIN; DARIS JEAN-PAUL; CORBEIL JACQUES
权利人:BRISTOL MYERS CO
摘要:Disclosed herein is a novel high beta -yield producing novel intermediates of the formula where R4 is useful in the synthesis of 1- beta -alkyl carbapenems.

专利号:US-4772683-A
优先权日:1986-02-24
标 题:High percentage beta-yield synthesis of carbapenem intermediates
发明人：MARTEL ALAIN; DARIS JEAN-PAUL; CORBEIL JACQUES
权利人:BRISTOL MYERS CO
摘要:Disclosed herein is a novel process using novel silyl enol ether intermediates of the formula 8 to generate novel azetidione thiolester intermediates of the formula 12 which can be used to form 1- beta -alkyl carbapenem antibiotics. It has now been discovered that if the R4 group is selected from a small group of moieties having the formula: an increased beta -yield of up to approximately 100% can be obtained.