CAS: 60984-57-8; N,N'-(Disulfanediylbis(Ethane-2,1-Diyl))Diacrylamide

相似化合物

54641-27-9 1190-73-4 638-44-8

上下游产品

cystamine dihydr°Chioride acryloyl chloride 2-mercaptoethylamine hydr°Chloride cystamine hydr°Chloride

半胱胺盐酸盐,丙烯酰氯置于sodium Hydroxide体系中,用 二氯甲烷,水 作为反应溶剂,化学反应 3.0H,以1.2 G的收率获得产物n,N'-双(丙稀酰)胱胺
参考文献:逐步的双重ph和氧化还原反应性交联多肽纳米颗粒,可增强细胞摄取和有效的癌症治疗.
标题:逐步的双重ph和氧化还原反应性交联多肽纳米颗粒,可增强细胞摄取和有效的癌症治疗.
摘要:对于有效的癌症治疗,仍然需要克服智能纳米颗粒(np)的全身毒性,减少的细胞内化作用以及不可控的细胞内药物释放.此处,一系列逐步双重ph值和氧化还原基于聚响应交联多肽(大号-Lysine-共-N-,ñ-双(丙烯酰基)cystamine-共-γ-谷氨酸(plbg),用于增强细胞摄取和有效的癌症治疗.所制备的交联plbg纳米颗粒(plbg-Nps)在生理条件下呈现带负电的表面,并且在ph值为〜的弱酸性肿瘤细胞外环境中观测到plbg-Nps的表面电荷从负向正转变. 6.5.最后,Plbg-Nps的内体逸出通过"质子海绵"效应而得以促进,该效应是在ph值为约5.0的肿瘤细胞的内/溶酶体环境中,通过聚合物链的质子化.此外,肿瘤细胞中高浓度的还原型谷胱甘肽(gsh)可通过以下途径触发药物的快速释放:Plbg-Np中二硫键的破坏.细胞毒性试验表明,未观测到plbg-Np的明显细胞毒性.但是,加载dox的
DOI:10.1039/c9Tb01773A

专利信息

专利号:US-2021206899-A1
优先权日:2020-09-14
标 题 :Synthesis of janus dendrimers
发明人：NAJAFI FAEZEH; Salami-Kalajahi Mehdi; ROGHANI-MAMAQANI HOSSEIN
权利人:NAJAFI FAEZEH; SALAMI KALAJAHI MEHDI; ROGHANI MAMAQANI HOSSEIN; SAHAND UNIV OF TECHNOLOGY
摘要:A method for synthesizing Janus dendrimers, including synthesizing a hydrophobized dendrimer by reacting a dendrimer with a carboxylic acid, forming a first dendron with a thiol group by splitting the hydrophobized dendrimer through breaking a disulfide bond of the core into thiol groups, forming a reactive dendron by reacting the thiol group of the first dendron with methyl acrylate and a radical initiator, synthesizing a primary core by reacting the reactive dendron with ethylenediamine (EDA), and forming a Janus dendrimer by synthesizing a second dendron on the primary core. The hydrophobized dendrimer includes a core containing a disulfide bond.

专利号:US-2002001821-A1
优先权日:1994-02-10
标 题:Methods for direct synthesis of compounds having complementary structure to a desired molecular entity and use thereof

专利号:US-6127154-A
优先权日:1994-02-10
标题 :Methods for direct synthesis of compounds having complementary structure to a desired molecular entity and use thereof
发明人：MOSBACH KLAUS; CORMACK PETER A G; RAMSTROEM OLOF; HAUPT KARSTEN
摘要:Compounds which possess a complementary structure to a desired molecule, such as a biomolecule, in particular polymeric or oligomeric compounds, which are useful as in vivo or in vitro diagnostic and therapeutic agents are provided. Also, various methods for producing such compounds are provided. These polymeric or oligomeric compounds are useful in particular as antimicrobial agents, receptor, hormone or enzyme agonists and antagonists.

专利号:WO-2024163462-A1
优先权日:2023-01-31
标 题:Magnetic hydrogel particles and methods of use
发明人：CHAN ALIX I; CUNNINGHAM CHRISTIAN NATHANIEL; PAEGEL BRIAN; CAVETT VALERIE
权利人:GENENTECH INC; UNIV CALIFORNIA
摘要:The present invention relates to particles comprising a magnetic core coated in a polymeric gel, methods of making such particles, and methods of using such particles, for example to support both chemical and biological synthesis.

专利号:WO-2024163471-A1
优先权日:2023-01-31
标题:Magnetic hydrogel particles and methods of use
发明人：PAEGEL BRIAN; CAVETT VALERIE
权利人:UNIV CALIFORNIA
摘要:The present invention relates to particles comprising a magnetic core coated in a polymeric gel, methods of making such particles, and methods of using such particles, for example to support both chemical and biological synthesis.

专利号:US-5994110-A
优先权日:1995-02-10
标 题 :Methods for direct synthesis of compounds having complementary structure to a desired molecular entity and use thereof
发明人：MOSBACH KLAUS; CORMACK PETER A G; RAMSTROM OLOF; HAUPT KARSTEN
摘要:Compounds which possess a complementary structure to a desired molecule, such as a biomolecule, in particular polymeric or oligomeric compounds, which are useful as in vivo or in vitro diagnostic and therapeutic agents are provided. Also, various methods for producing such compounds are provided. These polymeric or oligomeric compounds are useful in particular as antimicrobial agents, receptor, hormone or enzyme agonists and antagonists.