CAS: 621-82-9; Cinnamic Acid(Only Trans)

上下游产品

piperidine malonic acid benzaldehyde pyridine(carbonic acid ethyl ester)-cinnamic acid-anhydride 1,3,4,6-tetraphenylhexane-1,6-dione 2-hydroxyethyl 3-(phenyl)-2-propenoate 1-Phenylbut-1-en-3-one

肉桂醛置于氧气体系中,90.0 °C,500.01 Kpa 条件下,反应 5.0H,反应生成 肉桂酸
参考文献:连续流中连续双催化剂床上的级联好氧选择性氧化
标题:连续流中连续双催化剂床上的级联好氧选择性氧化
摘要:级联反应代表了一种原子经济且节能的技术,可减少化学制造所需的操作次数.生物催化级联在自然界无处不在.然而,控制反应物,中间体和活性位点之间相互作用的顺序仍然是化学催化的挑战.在这里,我们演示了一种通过流化法使用化学催化剂实现高效级联的方法.在连续流动操作下,双床配置中的pd / Sba-15和pt / Sba-15非均相催化剂的紧密偶联可提供84%的高单程收率(比批处理操作提高20倍),并且对于>肉桂醇向肉桂酸的级联氧化反应中有14000的周转率,尽管两种催化剂对该反应均没有活性.pd(第一床)和pt(第二床)催化剂的合理排序对于促进不希望的加氢和氢解反应的级联氧化至关重要,后者优于逆流床顺序或单个混合的pdpt反应器床.每个床的固有催化性能都保留在最佳的双床配置中,从而能够定量预测其单独氧化行为已建立的反应物/中间体的最终产品收率.使用连续的反应器床进行连续处理可实现采用"简单"催化剂的
DOI:10.1021/acscatal.9B00092

专利信息

专利号:US-7816544-B2
优先权日:2004-03-23
标 题:Synthesis of rocaglamide natural products via photochemical generation of oxidopyrylium species
发明人：JONES II GUILFORD; GERARD BAUDOUIN; PORCO JR JOHN A
权利人:UNIV BOSTON
摘要:The present invention provides new strategies for the synthesis of compounds of the rocaglamide family and related natural products. In particular, the new biomimetic synthetic approach involves photochemical generation of an oxidopyrylium species from a 3-hydroxychromone derivative followed by 1,3-dipolar cycloaddition of the oxidopyrylium species to a dipolarophile. This approach can be used for the formation of adducts containing an aglain core structure. Methods for the conversion of aglain core structures to aglain, rocaglamide and forbaglin ring systems are also provided. The present invention also relates to the use of rocaglamide/aglain/forbaglin derivatives for the manufacture of medicaments for use in the treatment of cancer or cancerous conditions, disorders associated with cellular hyperproliferation, or NF-κB-dependent conditions.

专利号:US-6610802-B2
优先权日:2001-05-29
标题 :Process for synthesis of polymer compositions, polymer compositionS obtainable by the process, and use of the same
发明人：ROOS SEBASTIAN; EISENBERG BORIS; HARPE CAROLIN
权利人:ROHMAX ADDITIVES GMBH
摘要:The present invention relates to a process for synthesis of polymer compositions with reduced catalyst content, wherein ethylenically unsaturated monomers containing less than 0.5 wt % of ethylenically unsaturated monomers with at least one carboxylic group, sulfonic acid group and/or at least one phosphonic acid group relative to the total weight of the ethylenically unsaturated monomers are polymerized by means of initiators containing a transferable group of atoms and of one or more catalysts comprising at least one transition metal in the presence of ligands which can form a coordination compound with the metal catalyst or catalysts and, after the polymerization, the catalyst contained in the polymer is at least partly separated. For this purpose, the polymer composition is filtered, after the polymerization, in the presence of at least one filter aid which contains at least 0.5 wt %, relative to the total weight of the filter aid, of repeating units that contain at least one carboxylic acid group, sulfonic acid group and/or at least one phosphonic acid group.

专利号:US-2025101045-A1
优先权日:2022-01-18
标题:Synthesis of boron-containing amidoxime reagents and their application to synthesize functionalized oxadiazole and quinazolinone derivatives
发明人：DAS BHASKAR
权利人:LONG ISLAND UNIV
摘要:The present disclosure is concerned with borylated amidoximes useful in the synthesis of biologically relevant drug-like molecules, including functionalized oxadizole and quinazolinone derivatives. Also disclosed are methods of making borylated amidoximes, methods of making functionalized oxadiazole and quinazolinone compounds using the amidoximes, and functionalized oxadiazole and quinazolinone compounds prepared from borylated amidoximes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-2012003164-A1
优先权日:1998-12-30
标题 :Cosmetic or dermatological composition containing an active agent which stimulates synthesis of the protein hsp 32 in the skin
发明人：NIZARD CARINE; MOREAU MARIELLE; BONTE FREDERIC
权利人:NIZARD CARINE; MOREAU MARIELLE; BONTE FREDERIC; DIOR CHRISTIAN PARFUMS
摘要:A dermatological or cosmetological composition for an external topical administration, included together with pharmaceutically and/or cosmetologically acceptable excipients: at least one UVA-stabilizing and/or UVB-stabilizing screening agent, at least one compound capable of activating the endogenous synthesis of Heat Shock Protein (HSP) 32 or a functional peptide fragment of such a protein, and forskolin or any extract containing it.

专利号:US-10604479-B2
优先权日:2013-11-18
标 题:Continuous process for the one-pot synthesis of metal salts and metal complexes
发明人：LEONARDI GIULIANO; GASPERONI GIOVANNI
权利人:VOLARE & CONNECTING LLC; LEONARDI GIULIANO; NOVUS INT INC
摘要:A continuous process is described for the one-pot synthesis of compounds, such as metal salts and metal complexes, as well as optionally for the protection of the compounds thus obtained by coating and/or impregnation with suitable compounds.

专利号:US-8404088-B2
优先权日:2006-05-22
标 题:Asymmetric synthesis of rocaglamides via enantioselective photocycloaddition mediated by chiral bronsted acids
发明人：PORCO JR JOHN A; GERARD BAUDOUIN
权利人:PORCO JR JOHN A; GERARD BAUDOUIN; UNIV BOSTON
摘要:The present invention provides a new strategies for the synthesis of compounds of the rocaglamide family and related natural products. The synthetic approach generally involves photochemical generation of an oxidopyrylium species from a 3-hydroxychromone derivative followed by an enantioselective 1,3-dipolar cycloaddition of the oxidopyrylium species to a dipolarophile in the presence of a TADDOL derivative. This approach can be used for the formation of adducts containing an aglain core structure. Methods of the conversion of aglain core structures to aglain, rocaglamide and forbaglin ring systems are also provided. The present invention also relates to the use of rocaglamide/aglain/forbaglin derivatives for the manufacture of medicaments for use in the treatment of cancer or cancerous conditions, disorders associated with cellular hyperproliferation, or NF-κB-dependent conditions.