CAS: 83480-29-9; (1S,2S,3R,4S,5S)-5-((1,3-Dihydroxypropan-2-yl)Amino)-1-(Hydroxymethyl)Cyclohexane-1,2,3,4-Tetraol

• 英文名称(1S,2S,3R,4S,5S)-5-((1,3-Dihydroxypropan-2-yl)Amino)-1-(Hydroxymethyl)Cyclohexane-1,2,3,4-Tetraol
• 中文名称伏格列波糖
• IUPAC名称(1S,2S,3R,4S,5S)-5-((1,3-dihydroxypropan-2-yl)amino)-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetraol
• 其它别名5-(1,3-Dihydroxypropan-2-ylamino)-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol
• CAS编号83480-29-9
• MFCD编号:MFCD00865496
• 分子式:C10H21NO7
• 分子量:267.28
• 产品CID: 1823418
• 产品分类原料药 → 激素及调节内分泌功能类药 → 胰腺激素及其它调节血糖药

• 相似结构搜索
• InChIKey: FZNCGRZWXLXZSZ-CIQUZCHMSA-N
• InChI=1S/C10H21NO7/c12-2-5(3-13)11-6-1-10(18,4-14)9(17)8(16)7(6)15/h5-9,11-18H,1-4H2/t6-,7-,8+,9-,10-/m1/s1…
• 计算化学: 氢键受体数8.0氢键供体数8.0可旋转键数5.0

物理性质

• 熔点162-163 °C
• 沸点601.9±55.0 °C at 760 mmHg
• 闪点274.1±22.1 °C
• 密度1.6±0.1 g/cm3
• PH:D25 +26.2° (c = 1 in water)
• pKa:13.26±0.70(预测)
• PSA:153.64
• LogP:-2.36
• 折射率1.636
• 蒸汽压0.0±3.9 mmHg at 25°C
• 溶解性DMSO (Slightly), Methanol (Very Slightly, Heated), Water (Sparingly, Sonicated)
• 外观形态白色至类白色固体
• 储存条件-20°C
• 产品应用伏格列波糖(83480-29-9)的用途:新型犴葡萄糖苷酶抑制剂.改善糖尿病饭后高血糖(本品只适用于患者接受饮食疗法,运动疗法没有得到明显效果时,或者患者除饮食疗法,运动疗法外还用口服降血糖药物或胰岛素制剂而没有得到明显效果时).

MSDS等安全信息

• GHS符号GHS07
• 警示词Warning
• 危险描述H302-H315-H319-H335
• 防范说明P261-P305+P351+P338
• UN编号NONH for all modes of transport
• 危险品标志Xi
• 安全声明36/37-37/39-26
• 危险类别码20/21/22-36/37/38
• WGK Germany3

上下游产品

合成工艺路线路线简述

• 合成目标产物 Voglibose 主要起始原料 Tetrabenzyl-Voglibose
• 96-26-4 + 83465-22-9 = 83480-29-9
  反应条件:1.1 Reagents: Hydrochloric Acid,Sodium Cyanoborohydride Solvents: Dichloromethane,Water; Rt; 16 H,70 °C; 70 °C -> Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 4,Rt1.3 Reagents: Sodium Hydroxide Solvents: Water; Ph 4.5,Rt
  标题:Diastereospecific Epoxidation And Highly Regioselective Ring-Opening Of (+)-Valienamine: Practical Synthesis Of (+)-Valiolamine
  作者:Ji,Li; Et Al
  参考文献:Tetrahedron 日期:2013 卷标:69(34) 页码:7031-7037]
  
  96-26-4 + 83465-22-9 = 83480-29-9
  反应条件:1.1 Reagents: Hydrogen,Hydrochloric Acid Catalysts: Palladium,Carbon Solvents: Methanol,Water; 10 H,3 - 4 Mpa,60 - 75 °C
  标题:Preparation Of Voglibose From Valiolamine
  作者:Lu,Chunlei; Et Al
  参考文献:Zhongguo Yiyao Gongye Zazhi 日期:2005 卷标:36(9)]
  
  118014-37-2 = 83480-29-9
  反应条件:1.1 Reagents: Barium Hydroxide Solvents: Water; 8 H,80 °C; 80 °C -> Rt1.2 Reagents: Carbon Dioxide; Rt1.3 Reagents: Amberlite Cg 50 Solvents: Water; 5 H,Rt1.4 Reagents: Dowex 50W Solvents: Water; 2 H,Rt2.1 Reagents: Hydrochloric Acid,Sodium Cyanoborohydride Solvents: Dichloromethane,Water; Rt; 16 H,70 °C; 70 °C -> Rt2.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 4,Rt2.3 Reagents: Sodium Hydroxide Solvents: Water; Ph 4.5,Rt
  标题:Diastereospecific Epoxidation And Highly Regioselective Ring-Opening Of (+)-Valienamine: Practical Synthesis Of (+)-Valiolamine
  作者:Ji,Li; Et Al
  参考文献:Tetrahedron 日期:2013 卷标:69(34) 页码:7031-7037

海关参考信息

• 2905122000-异丙醇
  2905143000-叔丁醇
  2905310000-1,2-乙二醇
  2905320000-1,2-丙二醇
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
• 详情请参考：📖 海关编码查询和海关进出口税则

其他信息查阅

• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
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