合成目标产物 Stearoyl Ethanolamide 主要起始原料 Monoethanolamine And Octadecanamide
(文献来源)合成步骤主要原料 Monoethanolamine 和 Octadecanamide
2-氨基乙基硬脂酸酯 反应生成硬脂酰胺mea 参考文献:Desnuelle; Naudet; Sambuc,Bulletin De La Societe Chimique De France,1949,P. 651 标题:Desnuelle; Naudet; Sambuc,Bulletin De La Societe Chimique De France,1949,P. 651
专利号:US-2024309142-A1 优先权日:2023-03-17 标题 :Capped block copolymers, their synthesis, manufacture, and methods of use 发明人:MAN VICTOR FUK-PONG; LI XIAOJIN HARRY; CHEN YIQING; PU GANG; HUNT JR CLINTON 权利人:ECOLAB USA INC 摘要:This disclosure relates to capped block copolymers, preferably reverse block copolymers capped with a hydrophobic group. Preferred hydrophobic groups include benzyl groups and silyl groups. In a preferred embodiment, the reverse block copolymer has at least two arms, wherein each arm is capped with a hydrophobic group. The disclosure also provides for the synthesis of the capped block copolymers as well as methods of using the capped block copolymers for defoaming and antifoaming applications.
专利号:WO-2005079742-A1 优先权日:2004-02-19 标 题:Cosmetic and/or dermatological agent for increasing the endogenous lipid content of the skin 发明人:VEEGER MARCEL; KLOTZ ANDREAS; ZUR MUEHLEN ANNETTE; THOERNER BRIGITTE 权利人:STOCKHAUSEN CHEM FAB GMBH; VEEGER MARCEL; KLOTZ ANDREAS; ZUR MUEHLEN ANNETTE; THOERNER BRIGITTE 摘要:The invention relates to the use of at least one active ingredient that is selected from the water-soluble groups: (a) allantoin; (b) salts and/or esters of gluconic acid and/or aspartic acid; (c) precursors of creatine, creatine and creatinine and their derivatives; (d) glycyrrhetinic acid or the salts and/or esters thereof; (e) D-panthenol and/or at least one active ingredient that is selected from the oil-soluble groups: (f) vitamin E acetate; (g) cholesterol; (h) derivatives of glycyrrhetinic acid, in so far as they are soluble in the oils and fats that are conventionally used in the cosmetic industry; (i) vegetable oils and fats; (j) non-saponifiable fractions of vegetable fats. Said active ingredients are used alone or in combination with one or more active ingredients from the groups (a) to (j) to produce a cosmetic and/or dermatological agent for stimulating the endogenous synthesis of barrier substances, in particular for increasing the endogenous lipid content of the skin.
专利号:US-9522192-B2 优先权日:2012-12-13 标 题:Polyethylene glycol derivatives of palmitoylethanolamide and analogous acylethanolamides 发明人:CALIGNANO ANTONIO; D'AGOSTINO GIUSEPPE; LANERI SONIA; MELI ROSARIA; OSTACOLO CARMINE; RUSSO ROBERTO; SACCHI ANTONIA; TRONINO DIANA; DELLA VALLE FRANCESCO; DELLA VALLE MARIA FEDERICA; MARCOLONGO GABRIELE 权利人:EPITECH GROUP SRL 摘要:The synthesis of a series of Polyethylene glycol conjugates (esters and carbonates) of PEA and its analogous acylethanolamides, have higher water solubility and good hydrophilic/lipophilic balance, resulting in (i) improved accumulation in tissues (particularly skin and mucosae), (ii) prolonged release, and (iii) increased bioavailability. Improvement of PEA and analogous acylethanolamides levels in the tissues—particularly in the skin and mucosae—and their prolonged release is due to the improved bioavailability of related conjugates. Conjugates are able to extend the time frame in which PEA and analogous acylethanolamides exert their pharmacological effects.
专利号:US-2023346952-A1 优先权日:2015-09-22 标题:Cannabinoid glycoside prodrugs and methods of synthesis 发明人:ZIPP BRANDON J; HARDMAN JANEE’ M; BROOKE ROBERT T; DEUTSCHER TYREL R 权利人:GRAPHIUM BIOSCIENCES INC 摘要:The present invention provides tetrahydrocannabinol glycoside and cannabidiol glycoside prodrugs and pharmaceutical compositions comprising these compounds, and their use for the site-specific delivery of tetrahydrocannabinol or cannabidiol. Also provided are processes for the preparation of purified tetrahydrocannabinol glycoside and cannabidiol glycoside prodrugs.
专利号:EP-3842443-B1 优先权日:2013-03-15 标 题 :Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
专利号:EP-2885416-B1 优先权日:2012-08-20 标 题 :Large scale enzymatic synthesis of oligosaccharides
1: Dubuc I, Prunier J, Lacasse É, Gravel A, Puhm F, Allaeys I, Archambault AS, Gudimard L, Villano R, Droit A, Flamand N, Boilard É, Flamand L. Cytokines and Lipid Mediators of Inflammation in Lungs of SARS-CoV-2 Infected Mice. Front Immunol. 2022 Jun 24;13:893792. doi: 10.3389/fimmu.2022.893792. 2: Chiurchiù V, Leuti A, Smoum R, Mechoulam R, Maccarrone M. Bioactive lipids ALIAmides differentially modulate inflammatory responses of distinct subsets of primary human T lymphocytes. FASEB J. 2018 Oct;32(10):5716-5723. doi: 10.1096/fj.201800107R. Epub 2018 Jun 7. BioBank Japan Project; Inohara H, Murakami Y, Matsuda K, Okada Y, Yamauchi T, Kadowaki T. Identification of serum metabolome signatures associated with retinal and renal complications of type 2 diabetes. Commun Med (Lond). 2023 Jan 9;3(1):5. doi: 10.1038/s43856-022-00231-3. 4: Alarcón-Yaquetto DE, Caballero L, Gonzales GF. Association Between Plasma N-Acylethanolamides and High Hemoglobin Concentration in Southern Peruvian Highlanders. High Alt Med Biol. 2017 Dec;18(4):322-329. doi: 10.1089/ham.2016.0148. Epub 2017 Jun 30.
合成参考文献
摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118 摘要: 摘要:Final Report 8/1995 Available from CIR 摘要:International Journal of Toxicology 34(Suppl.1):18-34, 2015