CAS: 1188-33-6; 1,1-Diethoxy-N,N-Dimethylmethanamine

上下游产品

CAS号64-17-5 乙醇 | CAS号3724-43-4 (氯亚甲基)二甲基氯化铵 | CAS号141-52-6 乙醇钠 | CAS号2214-82-6 bis(dimethylami... | CAS号368-39-8 三乙基氧鎓四氟硼酸盐 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号1071-38-1 (二甲氨基亚甲基)二甲基氯化铵 | CAS号111902-68-2 n2-(dimethylami... | CAS号111038-14-3 ethyl (2E)-2-cy... | CAS号5470-34-8 4'-甲氧基甲酰苯胺 | CAS号1152-75-6 N,N'-bis(4-meth... | CAS号1202-62-6 N,N-Dimethyl-N'... | CAS号598-94-7 N,N-二甲基脲 | CAS号83490-19-1 dimethylaminome... | CAS号35053-55-5 [2-(6-氯-3-吡嗪)-2... | CAS号34772-98-0 3-二甲氨基-1-(2-噻吩基...

2-[1-(氰基甲基)吡咯烷-2-亚基]丙二腈 以25%的收率获得
参考文献:Kadushkin,A. V.;Stezhko,T. V.;Granik,V. G.,Ximiya Geterotsikl. Soed.,1986,N 4,564-565
标题:Kadushkin,A. V.;Stezhko,T. V.;Granik,V. G.,Ximiya Geterotsikl. Soed.,1986,N 4,564-565

专利信息

专利号:US-11891375-B2
优先权日:2021-07-26
标 题 :Method for the synthesis of 2,4-dimethylpyrimidin-5-ol, intermediates, and method for the synthesis of Lemborexant using the intermediates
发明人：AKHATOU ABDESLAM; DOBARRO RODRÃ?GUEZ ALICIA
权利人:MOEHS IBERICA SL
摘要:A method is for the synthesis of 2,4-dimethylpyrimidin-5-ol, which can be used as an intermediate compound in the synthesis of Lemborexant. The method includes reacting a nitrophenyl compound with N,N-dimethylformamide diethyl acetal.

专利号:US-11274081-B2
优先权日:2016-05-30
标 题:Process for the synthesis of ivacaftor
发明人：REDDY DUMBALA SRINIVASA; KULKARNI AMOL ARVIND; NATARAJAN VASUDEVAN; SHARMA MRITYUNJAY KESHAVPRASAD
权利人:COUNCIL SCIENT IND RES
摘要:The present disclosed an improved process for the synthesis of ivacaftor starting from indole acetic acid ester which can be performed in batch as well as continuous flow synthesis. The present invention further disclosed to a continuous process for the synthesis of compound of formula (II) or formula (III) from compound of formula (I) in continuous flow reactor.

专利号:WO-9118002-A1
优先权日:1990-05-16
标 题 :Nucleosides as synthones for rna-synthesis
发明人：ERDMANN VOLKER; SPRINZL MATHIAS; HENCO KARSTEN
权利人:DIAGEN INST MOLEKULARBIO
摘要:Nucleosides are disclosed having formula (I), in which, when B represents guanine or 8-haloguanine, R?1 is an amidine protecting group, in particular the dimethylaminomethylene group (DMM) at the N?2 position of the purine group; R?2 is an alkylsilyl group or methyl group or hydrogen (H); R?3 is a triethylammonium H-phosphonate group, a hydrogen atom or a phosphoramidite group; R?4 is a substituted trityl protecting group or H, or when B represents adenine or 8-azidoadenine, R?1 is an amidine protecting group, in particular the dimethylaminomethylene group (DMM) at the N?6 position of the purine group and R?2, R?3 and R?4 have the same meanings as when B represents guanine. These compounds are useful as synthones for the chemical synthesis of RNA. When the DMM-protected purine bases adenine and guanine are used, coupling yields above 95 % are obtained.

专利号:US-5639785-A
优先权日:1995-06-07
标 题 :Methods for the treatment of baldness and gray hair using isoflavonoid derivatives
发明人：KUNG PATRICK C
权利人:GLOBAL PHARMA LTD
摘要:The present invention relates to novel pharmaceutical compositions of isoflavanoid derivatives useful for the treatment of male pattern baldness and alopecia areata, and their use in promoting the conversion of gray hair to the original pigment in hair follicles. Also described herein are methods for the synthesis of isoflavanoid derivatives.

专利号:US-10975096-B2
优先权日:2014-06-20
标题 :Synthesis of polycyclic-carbamoylpyridone compounds
发明人：CHIU ANNA; ENQUIST JR JOHN; GRIGGS NOLAN; HALE CHRISTOPHER; IKEMOTO NORIHIRO; KEATON KATIE ANN; KRAFT MATT; LAZERWITH SCOTT E; LEEMAN MICHEL; PENG ZHIHUI; SCHRIER KATE; TRINIDAD JONATHAN; VAN HERPT JOCHEM; WALTMAN ANDREW W
权利人:GILEAD SCIENCES INC
摘要:Methods of making compounds of Formula I are disclosed:

专利号:WO-2022127920-A1
优先权日:2020-12-18
标 题:Preparation method for and intermediate of 5'-nucleoside prodrug
发明人：SHEN JINGSHAN; HU TIANWEN; XIE YUANCHAO; ZHU FUQIANG
权利人:TOPHARMAN SHANGHAI CO LTD
摘要:Provided in the present invention are a preparation method for and an intermediate of a 5'-nucleoside prodrug. Specifically, provided in the present invention is a method for preparing a compound of formula VI. The method comprises the steps of: (a) reacting a compound of formula I and a compound of formula II to obtain a compound of formula III; (b) reacting the compound of formula III and reagent M to obtain a compound of formula IV; (c) reacting the compound of formula IV in the presence of reagent N to obtain a compound of formula V; and (d) reacting the compound of formula V with reagent O to obtain a compound of formula VI. The preparation method provided by the present invention has the advantages of having low costs, high yield, good product purity and the like, and is capable of achieving the efficient synthesis of 5'-nucleoside prodrugs.