CAS: 121-92-6; 3-Nitrobenzoic Acid

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CAS号585524-79-4 3-硝基苯硼酸新戊二醇酯 | CAS号124-38-9 二氧化碳 | CAS号99-61-6 间硝基苯甲醛 | CAS号65-85-0 苯甲酸 | CAS号101999-47-7 1-(3-nitropheny... | CAS号99-08-1 3-硝基甲苯 | CAS号610-29-7 2-硝基对苯二甲酸 | CAS号603-11-2 3-硝基邻苯二甲酸 | CAS号72802-41-6 2'-羟基-3-硝基苯乙酮 | CAS号619-25-0 3-硝基苯甲醇 | CAS号109899-85-6 1-(2-hydroxyphe... | CAS号109899-88-9 (2-acetylphenyl... | CAS号105686-75-7 4-amino-3-(3-ni... | CAS号3320-87-4 3-硝基苯基异氰酸酯 | CAS号3400-26-8 N-甲基-3-硝基苯甲酰胺 | CAS号42237-85-4 3-氨基-5-溴苯甲酸 | CAS号313502-13-5 6-氨基-2-(3-氨基苯基)苯并噁唑 | CAS号50765-19-0 3-碘-5-硝基苯甲酸甲酯 | CAS号341529-34-8 (3-硝基苯基)-哌嗪-1-甲酮 | CAS号606-18-8 2-氨基-3-硝基苯甲酸

三氯化苄置于硫酸,硝酸体系中,用 二氯甲烷 用作溶剂,化学反应 1.0H,以85%的收率获得间硝基苯甲酸
参考文献:Synthesis Of (3-Aminophenyl)(Morpholino)Methanone From Benzotrichloride As Precursor
标题:Synthesis Of (3-Aminophenyl)(Morpholino)Methanone From Benzotrichloride As Precursor
摘要:(3-氨基苯基)(吗啉基)甲酮衍生物是制备活性药物成分的关键中间体.在本合成中,我们选择了苯并三氯作为制备目标分子的前体,这种前体是很容易获得的原材料.本合成法由四个步骤组成,第一步是将三氯化苯硝化,得到偏硝基苯甲酸,再与亚硫酰氯氯化,得到偏硝基苯甲酰氯,与吗啉缩合后,用铁和盐酸进一步还原,形成目标分子.
Doi:10.14233/ajchem.2016.19419

专利信息

专利号:US-2021107859-A1
优先权日:2018-04-06
标题 :A process for the synthesis of carbon labeled organic compounds
发明人：AUDISIO DAVIDE; CANTAT THIBAULT; DESTRO GIANLUCA
权利人:COMMISSARIAT ENERGIE ATOMIQUE
摘要:A process for the synthesis of a carbon labeled organic compound containing a carbon labeled carboxyl group is described. A method of using carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; a process for manufacturing labeled pharmaceuticals and agrochemicals comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; and a process for producing tracers comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure are also described.

专利号:US-4400550-A
优先权日:1982-02-12
标题 :Synthesis of the navel orange worm pheromone (Z,Z)-11,13-hexadecadienal
发明人：BISHOP CLYDE E; MORROW GARY W
权利人:ALBANY INT CORP
摘要:A process for the synthesis of (Z,Z)-11-13-hexadecadienal is disclosed, starting with undecylenic alcohol.

专利号:US-2006052577-A1
优先权日:2001-02-06
标题:Methods of synthesis of polymers and copolymers from natural products
发明人：SWIFT GRAHAM; WESTMORELAND DAVID G; HUGHES KATHLEEN
权利人:SWIFT GRAHAM; WESTMORELAND DAVID G; HUGHES KATHLEEN
摘要:Described are polymers and copolymers containing sorbitol, citric acid, starch, aspartic acid, succinic anhydride, adipic acid mixtures thereof, methods of their synthesis and their uses.

专利号:US-2002192767-A1
优先权日:1999-10-13
标题 :Biosynthesis of polyketide synthase substrates
发明人：KHOSLA CHAITAN; PFEIFER BLAINE
摘要:The use of enzymes which catalyze the production of starter and extender units for polyketides is described. In addition, modified loading modules are described, which can accept a variety of starting units such as substituted benzoates, and which can be used to generate substituted derivatives of natural products. These enzymes may be used to enhance the yield of polyketides that are natively produced or polyketides that are rationally designed. By using these techniques, the synthesis of a complete polyketide has been achieved in E. coli . Production can be enhanced in microbial organisms of polyketides and other secondary metabolites by delaying production until after exponential phase and by maintaining relatively constant nutrient levels in the medium. In addition, polyketide production can be enhanced by providing an expression system for a thioesterase II. Thus, by modifying the host organism and changing the culture conditions, synthesis of a secondary metabolite can be enhanced. The present invention also results in a host organism with desirable characteristics to be used in the production of such polyketides and to assess the results of gene shuffling.

专利号:WO-02068613-A1
优先权日:2001-02-28
标题 :Biosynthesis of polyketide synthase substrates
发明人：KHOSLA CHAITAN; PFEIFER BLAINE
权利人:UNIV LELAND STANFORD JUNIOR; KHOSLA CHAITAN; PFEIFER BLAINE
摘要:The use of enzymes which catalyze the production of starter and extender units for polyketides is described. In addition, modified loading modules are described, which can accept a variety of starting units such as substituted benzoates, and which can be used to generate substituted derivatives of natural products. These enzymes may be used to enhance the yield of polyketides that are natively produced or polyketides that are rationally designed. By using these techniques, the synthesis of a complete polyketide has been achieved in E. coli. Production can be enhanced in microbial organisms of polyketides and other secondary metabolites by delaying production until after exponential phase and by maintaining relatively constant nutrient levels in the medium. In addition, polyketide production can be enhanced by providing an expression system for a thioesterase II. Thus, by modifying the host organism and changing the culture conditions, synthesis of a secondary metabolite can be enhanced. The present invention also results in a host organism with desirable characteristics to be used in the production of such polyketides and to assess the results of gene shuffling.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.