CAS: 1780-31-0; 2,4-Dichloro-5-Methylpyrimidine

相似化合物

1780-36-5 3177-24-0 34171-40-9

上下游产品

CAS号65-71-4 胸腺嘧啶 | CAS号50840-23-8 2-氨基-5-甲基嘧啶 | CAS号5151-34-8 2,4-二甲氧基-5-甲基嘧啶 | CAS号226905-70-0 2-chloro-5-meth... | CAS号20090-58-8 4-氯-5-甲基嘧啶-2-胺 | CAS号14394-70-8 4-氨基-2-氯-5-甲基嘧啶 | CAS号22536-61-4 2-氯-5-甲基嘧啶 | CAS号54-20-6 5-三氟甲基尿嘧啶 | CAS号55612-11-8 5'-O-TRITYL-2'-... | CAS号131022-67-8 2-氯-5-甲基-4-(噻吩-... | CAS号153600-16-9 2,4-二氯-5-三氯甲基嘧啶

胸腺嘧啶置于4-二甲氨基吡啶,氯化亚砜,三光气体系中,化学反应 8.0H,以93%的收率获得2,4-二氯-5-甲基嘧啶
参考文献:氮杂氮杂戊烯的高效无磷氯化反应及其在一锅法药物合成中的应用
标题:氮杂氮杂戊烯的高效无磷氯化反应及其在一锅法药物合成中的应用
摘要:用碳酸二(三氯甲基)酯(btc)和socl 2氯化羟基氮杂芳烃已经通过与5重量%的4-二甲基氨基吡啶(dmap)作为催化剂回流而有效地进行.各种底物都可以高产率氯化.所获得的氯化氮杂芳烃可通过简单的后处理直接直接用于大规模的一锅合成.
Doi:10.1021/acs.Oprd.9B00407

专利信息

专利号:US-2014135497-A1
优先权日:2012-11-13
标题 :Synthesis of 2,4-dichloro-5-trifluoromethyl-pyrimidine
发明人：LIU LI; AKALAY DENIZ; DONG WEITONG; FENG JIANQING; HEMP CHRISTIAN WOLFGANG; LU JUN; XIE LE; YANG JINSONG
权利人:LIU LI; AKALAY DENIZ; DONG WEITONG; FENG JIANQING; HEMP CHRISTIAN WOLFGANG; LU JUN; XIE LE; YANG JINSONG; BOEHRINGER INGELHEIM INT
摘要:This invention relates to a novel method for the synthesis of 2,4-dichloro-5-trifluoromethyl-pyrimidine useful as intermediate in the manufacture of pharmaceutically active ingredients.

专利号:WO-2025101716-A1
优先权日:2023-11-07
标题:Processes for synthesis of trifunctionalized sulfur(vi) compounds
发明人：LOPCHUK JUSTIN; SHULTZ ZACHARY; ATHAWALE PARESH
权利人:H LEE MOFFITT CANCER CT & RES
摘要:This disclosure describes processes for the asymmetric synthesis of trifunctionalized sulfur(VI) containing organic compounds of Formula I and Formula VI, as well as compounds of Formula I and Formula VI prepared by the processes described.

专利号:US-7122670-B2
优先权日:2003-09-05
标题:Selective synthesis of CF3-substituted pyrimidines
发明人：KATH JOHN CHARLES; RICHTER DANIEL TYLER; LUZZIO MICHAEL JOSEPH
权利人:PFIZER
摘要:The present invention relates to a method of making a compound of the formula n nwherein X 1 , X 2 and R 3 —R 4 are as defined herein. The method includes reacting a compound of the formulan n nwith an amine of formula 3 (HNR 3 R 4 ) in the presence of a Lewis Acid and a non-nucleophilic base. The 2,4-diamino pyrimidine moiety is a common component in a variety of biologically active drug-like molecules and pyrimidine derivatives have been found to be useful in the treatment of abnormal cell growth, such as cancer, in mammals.

专利号:US-6306977-B1
优先权日:1998-03-02
标 题 :Mercaptoalkylamide-functionalized resins
发明人：COPPO FRANK TEEN
权利人:DU PONT
摘要:Disclosed are polymers comprising mercaptoalkylamide-functionalized styrene units of Formula Iwhereinm is an integer from 1 to 3;R is H or C1-C3 alkyl; andQ is a bond, -CH2-, -CH2CH2-, -CH2CH2CH2- ora process for their preparation, and their use as supports for solid phase synthesis of small molecules and as supported nucleophiles to aid solution phase synthesis.

专利号:CA-2537373-C
优先权日:2003-09-05
标 题:Selective synthesis of cf3-substituted pyrimidines

专利号:US-2005101620-A1
优先权日:2003-09-05
标 题 :Selective synthesis of CF3-substituted pyrimidines