CAS: 2268-17-9; 2,4,6-Trifluorophenol

该化合物是一种多用途有机化合物,以其高纯度和稳定性而闻名,是合成各种药品和农用化学品的关键中间体,其三氟甲基混合物增强了有机溶剂的稳定性和溶性,提高了有机溶剂的溶性.该化合物的具体结构特征有助于其在化学反应中独特的反应性和选择性,使其成为有机合成中有价值的工具.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

2,4,6-trifluoroanisole 1,3,5-trifluorobenzene 2,4,6-trifluorophenylboronic acid (2,4,6-trifluoro-phenoxy)-acetic acid (S)-ethyl 1-(1-(tert-butyldimethylsilyloxy)-3-methylbutan-2-yl)-7-methoxy-4-oxo-6-((2,4,6-trifluorophenoxy)methyl)-1,4-dihydro-1,8-naphthyridine-3-carboxylate

合成工艺路线路线简述

    2,4,6-三氟苯甲醚置于氢碘酸,乙酸酐体系中,化学反应生成2,4,6-三氟苯酚
    参考文献:Aromatic Fluorine Compounds. Viii. Plant Growth Regulators And Intermediates1,2
    标题:Aromatic Fluorine Compounds. Viii. Plant Growth Regulators And Intermediates1,2
    摘要:
    Doi:10.1021/ja01510A021

    海关参考信息

    专利信息


    专利号:WO-2025149479-A1
    优先权日:2024-01-12
    标题:Synthesis of modified nucleoside triphosphates
    发明人:KUCHELMEISTER HANNES; PFAFFENEDER TONI; MEX MARTIN; VETH SIMON; MENKE JAN-MICHAEL
    权利人:ROCHE DIAGNOSTICS GMBH
    摘要:The invention relates to a new diastereoselective synthesis method for highly modified nucleoside triphosphates with two conjugable groups. The method works in liquid phase with conventional laboratory equipment as used in any chemical laboratory or production. For this, a new chiral P(V) phosphorylation reagent has been designed that allows highly efficient diastereoselective synthesis under mild conditions. Overall, a highly efficient, diastereoselective, high quality, cost-effective synthetic method of modified nucleoside triphosphates has been developed.

    专利号:US-9533959-B2
    优先权日:2013-10-07
    标 题:Methods of regioselective synthesis of 2,4-disubstituted pyrimidines
    发明人:CHARRIER JEAN-DAMIEN; O'DONNELL MICHAEL EDWARD
    权利人:VERTEX PHARMA
    摘要:The present invention relates to the novel regioselective syntheses of 2,4-disubstituted pyrimidines through sequential nucleophilic aromatic substitutions.

    专利号:US-6828466-B2
    优先权日:2002-07-19
    标题:Process for the synthesis of phenols from arenes
    发明人:MALECZKA JR ROBERT E; SMITH III MILTON R; HOLMES DANIEL; SHI FENG
    权利人:UNIV MICHIGAN STATE
    摘要:A process to synthesize substituted phenols such as those of the general formula RR'R''Ar(OH) wherein R, R', and R'' are each independently hydrogen or any group which does not interfere in the process for synthesizing the substituted phenol including, but not limited to, halo, alkyl, alkoxy, carboxylic ester, amine, amide; and Ar is any variety of aryl or hetroaryl by means of oxidation of substituted arylboronic esters is described. In particular, a metal-catalyzed C-H activation/borylation reaction is described, which when followed by direct oxidation in a single or separate reaction vessel affords phenols without the need for any intermediate manipulations. More particularly, a process wherein Ir-catalyzed borylation of arenes using pinacolborane (HBPin) followed by oxidation of the intermediate arylboronic ester by OXONE is described.

    专利号:US-10005737-B2
    优先权日:2013-10-07
    标题:Methods of regioselective synthesis of 2,4-disubstituted pyrimidines

    专利号:US-2015099875-A1
    优先权日:2013-10-07
    标题:Methods of regioselective synthesis of 2,4-disubstituted pyrimidines

    专利号:US-2016159749-A1
    优先权日:2013-10-07
    标题 :Methods of regioselective synthesis of 2,4-disubstituted pyrimidines
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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Daniela Smejkalová, Et Al. Binding Of Phenol And Differently Halogenated Phenols To Dissolved Humic Matter As Measured By Nmr Spectroscopy. Environ Sci Technol. 2009 Jul 15;43(14):5377-82.
    [参考文献]: Marie A Colucci, Et Al. Synthesis And Evaluation Of 3-Aryloxymethyl-1,2-Dimethylindole-4,7-Diones As Mechanism-Based Inhibitors Of Nad(P)H:Quinone Oxidoreductase 1 (Nqo1) Activity. J Med Chem. 2007 Nov 15;50(23):5780-9.
    [参考文献]: Roger Galve, Et Al. Development And Evaluation Of An Immunoassay For Biological Monitoring Chlorophenols In Urine As Potential Indicators Of Occupational Exposure. Anal Chem. 2002 Jan 15;74(2):468-78.

    合成参考文献


    参考文献:10.1007/978-3-030-17891-8_7
    摘要:Piccolo A, Spaccini R, Savy D, Drosos M, Cozzolino V. The Soil Humeome: Chemical Structure, Functions and Technological Perspectives. 2019. In: Sustainable Agrochemistry.
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