专利号:WO-2025149479-A1 优先权日:2024-01-12 标题:Synthesis of modified nucleoside triphosphates 发明人:KUCHELMEISTER HANNES; PFAFFENEDER TONI; MEX MARTIN; VETH SIMON; MENKE JAN-MICHAEL 权利人:ROCHE DIAGNOSTICS GMBH 摘要:The invention relates to a new diastereoselective synthesis method for highly modified nucleoside triphosphates with two conjugable groups. The method works in liquid phase with conventional laboratory equipment as used in any chemical laboratory or production. For this, a new chiral P(V) phosphorylation reagent has been designed that allows highly efficient diastereoselective synthesis under mild conditions. Overall, a highly efficient, diastereoselective, high quality, cost-effective synthetic method of modified nucleoside triphosphates has been developed.
专利号:US-9533959-B2 优先权日:2013-10-07 标 题:Methods of regioselective synthesis of 2,4-disubstituted pyrimidines 发明人:CHARRIER JEAN-DAMIEN; O'DONNELL MICHAEL EDWARD 权利人:VERTEX PHARMA 摘要:The present invention relates to the novel regioselective syntheses of 2,4-disubstituted pyrimidines through sequential nucleophilic aromatic substitutions.
专利号:US-6828466-B2 优先权日:2002-07-19 标题:Process for the synthesis of phenols from arenes 发明人:MALECZKA JR ROBERT E; SMITH III MILTON R; HOLMES DANIEL; SHI FENG 权利人:UNIV MICHIGAN STATE 摘要:A process to synthesize substituted phenols such as those of the general formula RR'R''Ar(OH) wherein R, R', and R'' are each independently hydrogen or any group which does not interfere in the process for synthesizing the substituted phenol including, but not limited to, halo, alkyl, alkoxy, carboxylic ester, amine, amide; and Ar is any variety of aryl or hetroaryl by means of oxidation of substituted arylboronic esters is described. In particular, a metal-catalyzed C-H activation/borylation reaction is described, which when followed by direct oxidation in a single or separate reaction vessel affords phenols without the need for any intermediate manipulations. More particularly, a process wherein Ir-catalyzed borylation of arenes using pinacolborane (HBPin) followed by oxidation of the intermediate arylboronic ester by OXONE is described.
专利号:US-10005737-B2 优先权日:2013-10-07 标题:Methods of regioselective synthesis of 2,4-disubstituted pyrimidines
专利号:US-2015099875-A1 优先权日:2013-10-07 标题:Methods of regioselective synthesis of 2,4-disubstituted pyrimidines
专利号:US-2016159749-A1 优先权日:2013-10-07 标题 :Methods of regioselective synthesis of 2,4-disubstituted pyrimidines
[参考文献]: Daniela Smejkalová, Et Al. Binding Of Phenol And Differently Halogenated Phenols To Dissolved Humic Matter As Measured By Nmr Spectroscopy. Environ Sci Technol. 2009 Jul 15;43(14):5377-82. [参考文献]: Marie A Colucci, Et Al. Synthesis And Evaluation Of 3-Aryloxymethyl-1,2-Dimethylindole-4,7-Diones As Mechanism-Based Inhibitors Of Nad(P)H:Quinone Oxidoreductase 1 (Nqo1) Activity. J Med Chem. 2007 Nov 15;50(23):5780-9. [参考文献]: Roger Galve, Et Al. Development And Evaluation Of An Immunoassay For Biological Monitoring Chlorophenols In Urine As Potential Indicators Of Occupational Exposure. Anal Chem. 2002 Jan 15;74(2):468-78.
合成参考文献
参考文献:10.1007/978-3-030-17891-8_7 摘要:Piccolo A, Spaccini R, Savy D, Drosos M, Cozzolino V. The Soil Humeome: Chemical Structure, Functions and Technological Perspectives. 2019. In: Sustainable Agrochemistry.