CAS: 26889-39-4; 2-Amino-2-Deoxyuridine

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2'-azido-2'-deoxyuridine guanosyl-(3',3')-(2'-amino-2'-deoxyuridine) 2'-amino-2'-deoxyadenosine 2'-amino-2'-deoxyinosine 2'-amino-2'-deoxyguanosine 9-(2-amino-2-deoxy-β-D-ribofuranosyl)-2-chlorohypoxanthine

尿嘧啶核苷置于碳酸二苯酯,四甲基乙二胺,叠氮基三甲基硅烷,水,Lithium Fluoride,三苯基膦体系中,用 甲醇,N,N-二甲基甲酰胺 用作溶剂,化学反应 3.0H,反应生成2'-氨基-D-尿苷
参考文献:通过呋喃修饰的寡脱氧核苷酸的原位氧化实现前所未有的 C 选择性链间交联
标题:通过呋喃修饰的寡脱氧核苷酸的原位氧化实现前所未有的 C 选择性链间交联
摘要:形成链间交联的化学试剂已在癌症治疗中使用了很长时间.它们共价连接两条 Dna 链,从而阻止转录.然而,交联修复酶可以恢复转录过程,导致对某些抗癌药物的耐药性.这些交联修复过程的机制尚未完全揭示.本研究的障碍之一是缺乏足够数量的明确,稳定,交联的双链体来研究交联修复酶的途径.我们的小组开发了一种交联策略,其中呋喃部分被整合到寡脱氧核苷酸 (Odn) 中.这些呋喃修饰的核酸可以在用 N-溴代琥珀酰亚胺选择性呋喃氧化后形成链间交联.我们在此报告了通过酰氨基或脲基接头在尿苷的 2'-位掺入呋喃部分.所得修饰的 Odn 显示出前所未有的选择性,可向与修饰残基相对的胞苷交联,形成一个特定的交联双链体,可以高产率分离.此外,形成的交联双链体的结构可以明确表征.
Doi:10.1021/ja1048169

专利信息

专利号:EP-2235177-B1
优先权日:2008-06-13
标 题 :Method for enzymatic synthesis of chemically modified rna
发明人：ROHAYEM JACQUES
权利人:RIBOXX GMBH
摘要:The present invention relates to a method for enzymatically synthesizing chemically modified RNA by using RNA-dependent RNA polymerases (RdRp), especially RdRps from viruses of the Caliciviridae family. The method of the present invention is particularly useful for preparing RNA molecules of increased stability especially with respect to RNA degradation, for example for in vivo applications. Further subject matter of the present invention relates to a kit for carrying out the enzymatic synthesis of the chemically modified RNA.

专利号:US-4849513-A
优先权日:1983-12-20
标 题 :Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
发明人：SMITH LLOYD M; FUNG STEVEN; KAISER ROBERT J
权利人:CALIFORNIA INST OF TECHN
摘要:The invention consists of compounds and methods for the synthesis of oligonucleotides which contain one or more free aliphatic amino groups attached to the sugar moieties of the nucleoside subunits. The synthetic method is versatile and general, permitting amino groups to be selectively placed at any position on oligonucleotides of any composition or length which is attainable by current DNA synthetic methods. Fluorescent dyes or other detectable moieties may be covalently attached to the amino groups to yield the corresponding modified oligonucleotide.

专利号:US-5118802-A
优先权日:1983-12-20
标 题:DNA-reporter conjugates linked via the 2' or 5'-primary amino group of the 5'-terminal nucleoside
发明人：SMITH LLOYD M; FUNG STEVEN; KAISER JR ROBERT J
权利人:CALIFORNIA INST OF TECHN
摘要:The invention consists of compounds and methods for the synthesis of oligonucleotides which contain one or more free aliphatic amino groups attached to the sugar moieties of the nucleoside subunits. The synthetic method is versatile and general, permitting amino groups to be selectively placed at any position on oligonucleotides of any composition or length which is attainable by current DNA synthetic methods. Fluorescent dyes or other detectable moieties may be covalently attached to the amino groups to yield the corresponding modified oligonucleotide.

专利号:US-5686599-A
优先权日:1992-05-14
标 题:Synthesis, deprotection, analysis and purification of RNA and ribozymes
发明人：TRACZ DANUTA
权利人:RIBOZYME PHARM INC
摘要:Method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form.

专利号:US-6649751-B2
优先权日:1992-05-14
标 题:Synthesis, deprotection, analysis and purification of RNA and ribozymes
发明人：USMAN NASSIM; WINCOTT FRANCINE; SWEEDLER DAVID; BEIGELMAN LEONID; DUDYCZ LECH W; GRIMM SUSAN; DIRENZO ANTHONY; TRACZ DANUTA
权利人:SIRNA THERAPEUTICS INC
摘要:Provided is a method for purification and synthesis of RNA molecules that have at least one chemical modification.

专利号:US-7041817-B2
优先权日:1992-05-14
标题:Synthesis, deprotection, analysis and purification of RNA and ribozymes
发明人：USMAN NASSIM; WINCOTT FRANCINE; SWEEDLER DAVID; BEIGELMAN LEONID; DUDYCZ LECH W; GRIMM SUSAN; DIRENZO ANTHONY; TRACZ DANUTA
权利人:SIRNA THERAPEUTICS INC
摘要:Method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form.