CAS: 359-07-9; 2-Bromo-1,1-Difluoroethane

上下游产品

1,1,2-tribromoethane difluoroethanol bromine 1,2-dibromo-1-chloroethane N-(2,2-difluoro-ethyl)-3-fluoro-anilineN-(2,2-difluoro-ethyl)-3-fluoro-aniline 2,2-difluoroethyl methyl ether Vinylidene fluoride biphenyl

氟化乙烯置于n-Bromobis(Trifluoromethyl)Amine体系中,化学反应生成1-溴-2,2-二氟乙烷
参考文献:氟化乙炔.第四部分 的制备nn-Bistrifluoromethylprop-1-炔基胺和的尝试制备氟nn-Bistrifluoromethylethynylamine
标题:氟化乙炔.第四部分 的制备nn-Bistrifluoromethylprop-1-炔基胺和的尝试制备氟nn-Bistrifluoromethylethynylamine
摘要:N-溴代双三氟甲基胺在自由基条件下与丙炔反应,以高收率获得顺式和反式-溴-Nn-双三氟甲基丙-1-烯基胺的混合物.在脱溴化氢的顺式-反式烯烃混合物给出主要nn-Bistrifluoromethylpropadienylamine和nn-Bistrifluoromethylprop-1-炔基胺,用少量一起nn-Bistrifluoromethylprop-2-炔基胺.溴化氢与反应nn-Bistrifluoromethylprop-1-炔基胺离子条件下得到1-溴nn-双三氟甲基丙-1-烯胺,表示乙炔在(cf 3)2 N.[省略图示].ch 3的意义上被极化.N-溴双三氟甲胺与氟乙烯在自由基条件下的反应得到2-溴-2-氟-Nn-双三氟甲基乙胺和2-溴-1-氟-Nn-双三氟甲基乙胺的混合物(比例为94:6);在离子条件下的相应反应主要产生2-溴-1,1-二氟乙烷和全氟-2-氮杂丙烯.
Doi:10.1039/j39690001955

专利信息

专利号:US-5985844-A
优先权日:1992-03-26
标题:Homoerythromycin A derivatives modified at the 4'-and 8A-positions
发明人：HECK JAMES V; LEANZA WILLIAM J; RATCLIFFE RONALD W; SALZMANN THOMAS N; SHANKARAN KOTHANDARAMAN; SZYMONIFKA MICHAEL J; WILKENING ROBERT R
权利人:MERCK & CO INC
摘要:Compounds of the formula: where R is hydrogen, hydroxyl, alkyl or acyl, R' and R'' together are oxo, hydroxyimino or alkoxyimino, and R' and R'' independently are hydrogen, hydroxyl, acyloxy, or amino substituted by any of hydrogen, alkylcarbonyl, arylcarbonyl, aralkylcarbonyl, alkoxycarbonyl, aralkoxycarbonyl, alkylsulfonyl or arylsulfonyl, and n is 0 or 1, and the pharmaceutically acceptable salts thereof. The compounds are macrolide antibiotics and are also useful as intermediates to the synthesis of other macrolide antibiotics. Pharmaceutical compositions and methods of their use are also provided for.

专利号:WO-2024041503-A1
优先权日:2022-08-22
标 题:Compounds targeting y220c mutant of p53
发明人：LI SUJING; LI AMIN; ZHENG QIAN; Dang Chaojie; FAN XINRUI; LONG WEI; WANG YANPING
权利人:JACOBIO PHARMACEUTICALS CO LTD
摘要:The present invention discloses compounds of formula (I) which can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. Also provided are processes for the synthesis and use of the compounds of formula (I).

专利号:EP-0508699-B1
优先权日:1991-04-04
标 题 :9-Deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4'- and 8a-positions
发明人：HECK JAMES V; LEANZA WILLIAM J; RATCLIFFE RONALD W; SALZMANN THOMAS N; WILKENING ROBERT R; SZYMONIFKA MICHAEL J; SHANKARAN KOTHANDARAMAN
权利人:MERCK & CO INC
摘要:Compounds of the formula: where R is hydrogen, hydroxyl, alkyl or acyl, R min and R sec together are oxo, hydroxyimino or alkoxyimino, and R min and R sec independently are hydrogen, hydroxyl, acyloxy, or amino substituted by any of hydrogen, alkylcarbonyl, arylcarbonyl, aralkylcarbonyl, alkoxycarbonyl, aralkoxycarbonyl, alkylsulfonyl or arylsulfonyl, and n is 0 or 1, and the pharmaceutically acceptable salts thereof. The compounds are macrolide antibiotics and are also useful as intermediates to the synthesis of other macrolide antibiotics. Pharmaceutical compositions and methods of their use are also provided for.

专利号:US-6586615-B1
优先权日:2001-01-10
标题:α-aminoboronic acids prepared by novel synthetic methods
发明人：KETTNER CHARLES A; JAGANNATHAN SHARADA; FORSYTH TIMOTHY PATRICK
权利人:BRISTOL MYERS SQUIBB CO
摘要:The present invention relates to a novel class of alpha-aminoboronic acids of Formula (V),which are useful as intermediates in synthetic processes for inhibitors of the serine proteases, leukocyte elastase, pancreatic elastase, cathepsin G, and chymotrypsin. More specifically, the alpha-aminoboronic acids are useful as intermediates for the synthesis of Hepatitis C Virus (HCV) protease inhibitors. This invention also generally relates to novel methods for the preparation of alpha-aminoboronic acids.

专利号:WO-2010096722-A1
优先权日:2009-02-20
标 题 :3-oxo-2, 3-dihydro- [1,2, 4] triazolo [4, 3-a]pyridines as soluble epoxide hydrolase (seh) inhibitors
发明人：FENG JUN; KEUNG WALTER; NOTZ WOLFGANG REINHARD LUDWIG
权利人:TAKEDA PHARMACEUTICAL; FENG JUN; KEUNG WALTER; NOTZ WOLFGANG REINHARD LUDWIG
摘要:Claimed are intermediates in the synthesis of N-Arylmethyl-3-Oxo-2,3-dihydro- [1,2,4]triazolo[4,3-a]pyridine-6-carboxamides as well as a process (A) to arrive at 3-Oxo-2, 3-dihydro-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid. The triazolo[4,3-a]pyridine-6-carboxamides of formula (I) are used as soluble epoxide hydrolase inhibitors (sEH) having therapeutic effect in pathologic conditions such as hypertension, stroke, inflammatory processes, diabetes and a variety of cardiovascular diseases.

专利号:US-3963734-A
优先权日:1971-09-17
标 题:Lower alkylsulfonyl 2-amino, 3-nitro pyridines
发明人：DOHERTY GEORGE O P; FUHR KENNETH H
权利人:LILLY CO ELI
摘要:Substituted 1-hydroxy-2-(1,1-difluoroalkyl)-1H-imidazo-(4,5-b)pyridine compounds useful as herbicides; and intermediates useful in the synthesis of these compounds. In addition to exhibiting herbicidal activity, the substituted 1-hydroxy-2-(1,1-difluoroalkyl)-1H-imidazo(4,5-b)pyridine compounds are of low mammalian toxicity.