专利号:US-8735586-B2 优先权日:2007-06-26 标 题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles 发明人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR 权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR; SANOFI SA 摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.
专利号:US-8188282-B2 优先权日:2006-07-15 标 题:Regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles 发明人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; HALLAND NIS; RKYEK OMAR; URMANN MATTHIAS 权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; HALLAND NIS; RKYEK OMAR; URMANN MATTHIAS; SANOFI AVENTIS 摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct palladium catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides useful for the production of pharmaceuticals, diagnostic agents, liquid crystals, polymers, herbicides, fungicidals, nematicidals, parasiticides, insecticides, acaricides and arthropodicides.
专利号:WO-0220630-A1 优先权日:2000-09-08 标 题 :Process for the preparation of glycerol-based crosslinked polymeric gels 发明人:PILLAI V N RAJASEKHARAN; DHANAPAL BOOPATHY 权利人:LIPAL BIOCHEMICALS; PILLAI V N RAJASEKHARAN; DHANAPAL BOOPATHY 摘要:The present invention relates to a process for the preparation of crosslinked polymeric gels for solid phase synthesis, the respective gels and their use. The gels are prepared by radical-induced copolymerisation of monomeric molecules and bifunctional crosslinking agents.
专利号:US-2010261909-A1 优先权日:2007-06-26 标题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
专利号:WO-2009000413-A1 优先权日:2007-06-26 标题:A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
专利号:AU-2007276514-A1 优先权日:2006-07-15 标题:A regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles
参考标题:Pd-Catalyzed Asymmetric Suzuki-Miyaura Coupling Reactions For The Synthesis Of Chiral Biaryl Compounds With A Large Steric Substituent At The 2-Position 作者:Yongsu Li,Bendu Pan,Xuefeng He,Wang Xia,Yaqi Zhang,Hao Liang,Chitreddy V Subba Reddy,Rihui Cao,Liqin Qiu 摘要:Pd-Catalyzed Asymmetric Suzuki-Miyaura Couplings Of 3-Methyl-2-Bromophenylamides, 3-Methyl-2-Bromo-1-Nitrobenzene And 1-Naphthaleneboronic Acids Have Been Successfully Developed And The Corresponding Axially Chiral Biaryl Compounds Were Obtained In Very High Yields (Up To 99%) With Good Enantioselectivities (Up To 88% Ee) Under Mild Conditions. The Chiral-Bridged Biphenyl Monophosphine Ligands Developed
合成参考文献
参考文献:10.1055/s-0030-1259067 摘要:Rangappa K, Chandrappa S, Vinaya K, Ramakrishnappa T. An Efficient Method for Aryl Nitro Reduction and Cleavage of Azo Compounds Using Iron Powder/Calcium Chloride. Synlett. 2010 Nov 24;2010(20):3019–22. doi: 10.1055/s-0030-1259067.