专利号:US-4092323-A 优先权日:1975-09-16 标 题 :Hydrazine derivatives of pyridyl-ketones 发明人:FOSTER ROBERT; PRESTON ROGER EDWIN; ROBINSON GRAHAM ERNEST 权利人:ICI LTD 摘要:The disclosure relates to novel protected ketone derivatives, for example dimethyl 3-(3-chlorophenoxy)-2-semicarbazonopropylphosphonate, for use as intermediates in the synthesis of known prostaglandin analogues, and to a process for their manufacture.
专利号:US-7754188-B2 优先权日:2003-06-30 标 题:Radiolabeled cannabinoid-1 receptor modulators 发明人:BURNS H DONALD; CHEN ALEX M; GIBSON RAYMOND E; GOULET MARK T; HAGMANN WILLIAM K; HAMILL TERENCE G; JEWELL JAMES P; LIN LINUS S; LIU PING; PERESYPKIN ANDREY V 权利人:MERCK SHARP & DOHME 摘要:The present invention relates to particular radiolabeled Cannabinoid-1 (CB1) receptor modulators, and methods of using these modulators for labeling and diagnostic imaging of Cannabinoid-1 receptors in mammals, particularly humans. In addition, intermediates useful for the synthesis of the radiolabeled Cannabinoid-1 receptor modulators are also disclosed, as well as the processes for synthesizing the radiolabeled Cannabinoid-1 receptor modulators. Still further, formulations of the radiolabeled Cannabinoid-1 receptor compounds are described.
专利号:US-4046841-A 优先权日:1975-09-16 标 题 :Phosphonates containing protected ketone group 发明人:FOSTER ROBERT; PRESTON ROGER EDWIN; ROBINSON GRAHAM ERNEST 权利人:ICI LTD 摘要:The disclosure relates to novel protected ketone derivatives, for example dimethyl 3-(3-chlorophenoxy)-2-semicarbazonopropylphosphonate, for use as intermediates in the synthesis of known prostaglandin analogues, and to a process for their manufacture.
专利号:US-4433149-A 优先权日:1981-08-25 标题 :Esters of ureido-phenyl (or pyridyl) phosphinic acids 发明人:LEE SHY-FUH 权利人:ZOECON CORP 摘要:Substituted tetrahydrobenzodiazaphosphorindiones or tetrahydropyridodiazaphosphorindiones, intermediates therefore, synthesis thereof, said compounds being useful herbicides.
专利号:CN-104529884-A 优先权日:2014-12-02 标题:A kind of green synthesis method for preparing N-alkylpyridone
专利号:CN-101830845-A 优先权日:2010-05-28 标 题 :Synthesis method of 5-chloro-2,3-dihydroxyl pyridine
[参考文献]: D L Gustafson, Et Al. Enhancement Of Xanthine Dehydrogenase Mediated Mitomycin C Metabolism By Dicumarol. Cancer Res. 1992 Dec 15;52(24):6936-9. [参考文献]: D L Gustafson, Et Al. Kinetics And Mechanism Of Mitomycin C Bioactivation By Xanthine Dehydrogenase Under Aerobic And Hypoxic Conditions. Cancer Res. 1993 Nov 15;53(22):5470-4.
合成参考文献
摘要:Scholz, U.; Dong, W.; Feng, J.; Shi, W., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 2, 70. 摘要:c E. Spinner and G.B. Yeoh. J. Chem. Soc., B 1971, 296. 摘要:D.J. Brown and J.S. Harper. J. Chem. Soc. 1965, 5542. 摘要:Lin, Z.; Tao, R.; Zhao, Y., Science of Synthesis: Knowledge Updates, (2023) 1, 405.