CAS: 4362-40-7; 4-(Chloromethyl)-2,2-Dimethyl-1,3-Dioxolane

该化合物是一种多用途化学中间体,主要用于有机合成和制药应用,其主要结构特征包括反应性氯甲基组和稳定的二氧酚环,它对于引入功能组或保护温和条件下的甲酰胺和氯酮很有价值.普通有机溶剂的稳定性和溶性增强了其在多步骤合成途径中的用途.它对于准备异环化合物和作为进一步衍生的前体特别有用.二甲基组的不发育障碍助长了其反应的选择性,而氯甲基混合物允许高效的核细胞替代.

结构式图片

相似化合物

57044-24-3 60456-22-6 36236-76-7

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

acetone 3-mon°Chloro-1,2-propanediol epichlorohydrin (R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol 2,2-dimethyl-4-methylidene-1,3-dioxolane bis((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)amine 4-aminomethyl-2,2-dimethyl[1,3]dioxolane rac-2,3-O-isopropylideneglycerol-1-diphenylphosphane

合成工艺路线路线简述

  • 合成目标产物 4-(Chloromethyl)-2,2-Dimethyl-1,3-Dioxolane 主要起始原料 3-Chloro-1,2-Propanediol
  • (文献来源)合成步骤主要原料 3-Chloro-1,2-Propanediol
丙酮缩甘油置于四氯化碳,Cross-Linked Polymer (Containing 2.50 Mmol Of Phosphine/g)体系中,化学反应 6.0H,以78%的收率获得产物4-(氯甲基)-2,2-二甲基-1,3-二噁烷
参考文献:Preparation Of Alkyl Chlorides,Acid Chlorides,And Amides Using Polymer-Supported Phosphines And Carbon Tetrachloride: Mechanism Of These Reactions
标题:Preparation Of Alkyl Chlorides,Acid Chlorides,And Amides Using Polymer-Supported Phosphines And Carbon Tetrachloride: Mechanism Of These Reactions
摘要:
DOI:10.1021/jo00169A022

海关参考信息

专利信息


专利号:US-9388168-B2
优先权日:2012-12-25
标 题:Process for the preparation of 1-([1,3]dioxolan-4-ylmethyl)-1H-pyrazol-3-ylamine
发明人:CHEN JUNLI; REN YI; SHE JIN; WANG LIN
权利人:HUA MEDICINE
摘要:The present invention relates to a novel process for the preparation of of the formula (I) (I) wherein R 1 and R 2 are described herein. The compounds prepared by the present invention are useful in the synthesis and manufacture of compounds for treating diseases or conditions associated with inhibiting actin polymerization.

专利号:EP-2687521-B1
优先权日:2012-07-20
标 题 :'Process for the enantioselective synthesis of landiolol'
发明人:GARAVAGLIA FABIO; ROLETTO JACOPO; PAISSONI PAOLO
权利人:PROCOS SPA

专利号:EP-2687521-A1
优先权日:2012-07-20
标题:'Process for the enantioselective synthesis of landiolol'

专利号:US-4413142-A
优先权日:1981-03-18
标 题:Method for preparing L-carnitine
发明人:FIORINI MARIO; VALENTINI CLAUDIO
权利人:ANIC SPA
摘要:L-carnitine is prepared by a synthesizing process starting from D-mannitol. The synthesis is started with the formation of a D-mannitol ketonide (more specifically D-mannitol acetonide from D-mannitol and acetone, whereafter the D-mannitol is split by oxidation to give glyceraldehyde acetonide, which is further reduced to glycerol acetonide. Then the free hydroxyl group is exchanged with a halogen atom (chlorine) with the formation of chlorodihydroxy propane, the primary alcoholic group of which is functionalized with the acid chloride of a sulfonic acid (tosylchloride). The reaction of the tosyl derivative with the salt of hydrogen cyanide leads to the formation of the corresponding nitrile which, when reacted with trimethylamine gives carnitinonitrile. The nitrile group is now hydrolyzed to give L-carnitine chloride. The formation of L-carnitine can then be obtained by exchanging the chloride ion with a hydroxyl ion.

专利号:CN-120665043-A
优先权日:2025-08-19
标题:Continuous flow synthesis method of 4- (chloromethyl) -2, 2-dimethyl-1, 3-dioxolane

专利号:PL-206308-B1
优先权日:2000-07-28
标题 :2,2-disubstituted 1,3-dioxolanes, the method of their preparation, the method of their optical separation and their application and the method of levodropropizine synthesis
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合成参考文献


摘要:Suginome, M.; Ohmura, T., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 171.
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