丙酮缩甘油置于四氯化碳,Cross-Linked Polymer (Containing 2.50 Mmol Of Phosphine/g)体系中,化学反应 6.0H,以78%的收率获得产物4-(氯甲基)-2,2-二甲基-1,3-二噁烷 参考文献:Preparation Of Alkyl Chlorides,Acid Chlorides,And Amides Using Polymer-Supported Phosphines And Carbon Tetrachloride: Mechanism Of These Reactions 标题:Preparation Of Alkyl Chlorides,Acid Chlorides,And Amides Using Polymer-Supported Phosphines And Carbon Tetrachloride: Mechanism Of These Reactions 摘要: DOI:10.1021/jo00169A022
专利号:US-9388168-B2 优先权日:2012-12-25 标 题:Process for the preparation of 1-([1,3]dioxolan-4-ylmethyl)-1H-pyrazol-3-ylamine 发明人:CHEN JUNLI; REN YI; SHE JIN; WANG LIN 权利人:HUA MEDICINE 摘要:The present invention relates to a novel process for the preparation of of the formula (I) (I) wherein R 1 and R 2 are described herein. The compounds prepared by the present invention are useful in the synthesis and manufacture of compounds for treating diseases or conditions associated with inhibiting actin polymerization.
专利号:EP-2687521-B1 优先权日:2012-07-20 标 题 :'Process for the enantioselective synthesis of landiolol' 发明人:GARAVAGLIA FABIO; ROLETTO JACOPO; PAISSONI PAOLO 权利人:PROCOS SPA
专利号:EP-2687521-A1 优先权日:2012-07-20 标题:'Process for the enantioselective synthesis of landiolol'
专利号:US-4413142-A 优先权日:1981-03-18 标 题:Method for preparing L-carnitine 发明人:FIORINI MARIO; VALENTINI CLAUDIO 权利人:ANIC SPA 摘要:L-carnitine is prepared by a synthesizing process starting from D-mannitol. The synthesis is started with the formation of a D-mannitol ketonide (more specifically D-mannitol acetonide from D-mannitol and acetone, whereafter the D-mannitol is split by oxidation to give glyceraldehyde acetonide, which is further reduced to glycerol acetonide. Then the free hydroxyl group is exchanged with a halogen atom (chlorine) with the formation of chlorodihydroxy propane, the primary alcoholic group of which is functionalized with the acid chloride of a sulfonic acid (tosylchloride). The reaction of the tosyl derivative with the salt of hydrogen cyanide leads to the formation of the corresponding nitrile which, when reacted with trimethylamine gives carnitinonitrile. The nitrile group is now hydrolyzed to give L-carnitine chloride. The formation of L-carnitine can then be obtained by exchanging the chloride ion with a hydroxyl ion.
专利号:PL-206308-B1 优先权日:2000-07-28 标题 :2,2-disubstituted 1,3-dioxolanes, the method of their preparation, the method of their optical separation and their application and the method of levodropropizine synthesis