CAS: 538-75-0; N,N-Dicyclohexylcarbodiimide(Dcc)

相似化合物

1122-82-3 32175-00-1 1202-53-5

上下游产品

CAS号2387-23-7 N,N’-二环己基脲 | CAS号931-53-3 环己基异腈 | CAS号108-91-8 环己胺 | CAS号1212-29-9 N,N'-二环己基硫脲 | CAS号3173-53-3 环己基异氰酸酯 | CAS号603-35-0 三苯基膦 | CAS号34656-93-4 N,N'-dicyclohex... | CAS号1122-82-3 环己基异硫氰酸酯 | CAS号24901-29-9 Phospholane,3-m... | CAS号98-59-9 对甲苯磺酰氯(PTSC) | CAS号10450-11-0 N-环己基-2-苯并噁唑胺 | CAS号2719-26-8 Cyclohexanecarb... | CAS号106694-64-8 dodecyl N,N'-di... | CAS号55750-62-4 3-马来酰亚胺丙酸 N-羟基琥珀酰亚胺酯 | CAS号57-13-6 尿素 | CAS号32449-99-3 2-(2-(1H-吲哚-3-基... | CAS号35824-91-0 1,3-双环己基巴比妥酸 | CAS号4975-73-9 N,N'-二环己基-4-吗啉脒 | CAS号888-71-1 3,5-二苯基-1,2,4-噁二唑 | CAS号55-21-0 苯甲酰胺

N,N'-Dicyclohexyl-Chlorformamidin置于sodium Hydroxide体系中,用 水 作为反应溶剂,以92.4%的收率获得产物n,N'-二环己基碳二亚胺
参考文献:一种利用vilsmeier试剂制备二环己基碳二亚胺的方法
标题:一种利用vilsmeier试剂制备二环己基碳二亚胺的方法
摘要:本发明公开了一种利用vilsmeier试剂制备二环己基碳二亚胺的方法,利用n,N‑二甲基甲酰胺(Dmf)和氯化亚砜(Socl2)制得vilsmeier试剂与二环己基脲(Dcu)反应,经过后处理后得到二环己基碳二亚胺.该方法采用了vilsmeier试剂,能够在较温和的条件下进行反应,工艺安全稳定,适合工业化大规模生产.

专利信息

专利号:US-6683189-B1
优先权日:1996-02-26
标 题 :Method for the synthesis of pyrrole and imidazole carboxamides on a solid support
发明人：DERVAN PETER B; BAIRD ELDON
权利人:CALIFORNIA INST OF TECHN
摘要:The present invention describes a novel method for the solid phase synthesis of polyamides containing imidazole and pyrrole carboxamides. The polyamides are prepared on a solid support from aromatic carboxylic acids and aromatic amines with high stepwise coupling yields (>99%), providing milligram quantities of highly pure polyamides. The present invention also describes the synthesis of analogs of the natural products Netropsin and Distamycin A, two antiviral antibiotics. The present invention also describes a novel method for the solid phase synthesis of imidazole and pyrrole carboxamide polyamide-oligonucleotide conjugates. This methodology will greatly increase both the complexity and quantity of minor-groove binding polyamides and minor-groove binding polyamide-oligonucleotide conjugates which can be synthesized and tested.

专利号:WO-2021014395-A1
优先权日:2019-07-24
标题:Process for the synthesis of deuterated capsaicin, capsaicinoids and synthetic capsaicin analogs
发明人：ORUGANTI SRINIVAS; AMRUTAPU SRAVANTH KUMAR; SAMPATH MAGESH; SEN SAIKAT
权利人:DR REDDY’S INST OF LIFE SCIENCES
摘要:The present application provides novel processes for the synthesis of deuterated intermediates of capsaicinoids, particularly II, III, IV and V of capsaicinoids, relating to pharmaceutical applications. The invention also provides novel intermediates of compounds of formula IX, XIV, XV, XVI, XVII, XVIII, XX and XXI utilized in the process of making deuterated capsaicin II, III, IV and V.

专利号:US-11274081-B2
优先权日:2016-05-30
标 题:Process for the synthesis of ivacaftor
发明人：REDDY DUMBALA SRINIVASA; KULKARNI AMOL ARVIND; NATARAJAN VASUDEVAN; SHARMA MRITYUNJAY KESHAVPRASAD
权利人:COUNCIL SCIENT IND RES
摘要:The present disclosed an improved process for the synthesis of ivacaftor starting from indole acetic acid ester which can be performed in batch as well as continuous flow synthesis. The present invention further disclosed to a continuous process for the synthesis of compound of formula (II) or formula (III) from compound of formula (I) in continuous flow reactor.

专利号:WO-2024055132-A1
优先权日:2022-09-12
标 题 :Method for the synthesis of a branched copolymer of hyaluronic acid and poly(lactic-co-glycolic) acid
发明人：VILOS ORTIZ CRISTIAN ANDRÉS; ZACCONI FLAVIA CRISTINA MILAGRO; SALAZAR MUÑOZ JAVIER ALONSO
权利人:UNIV TALCA; UNIV PONTIFICIA CATOLICA CHILE; FUND CENTRO DE NANOCIENCIA Y NANOTECNOLOGIA
摘要:The present invention provides a method for the synthesis of a branched copolymer of hyaluronic acid (HA) and poly(lactic-co-glycolic acid) (PLGA), and the branched copolymer thus obtained (HA-g-PLGA). Said method comprises activating the PLGA with coupling reagents in a water miscible solvent; solubilizing the HA in a phosphate buffered saline solution; and adding the activated PLGA solution dropwise to the solution with HA to obtain the branched copolymer. The advantages of the present method are that it uses environmentally friendly conditions and allows the copolymer to be synthesized and purified in less than a week under laboratory conditions. In addition, the branched copolymer obtained does not present traces of any of the reagents used for its synthesis, so it can be used directly in the development of applications for human use.

专利号:WO-2004037772-A1
优先权日:2002-10-22
标 题 :Convenient and scalable synthesis of ethyl n-[(2-boc-amino) ethyl] glycinate and its hydrochloride salt
发明人：HUDSON ROBERT H E; VIIRRE RUSSELL D
权利人:UNIV WESTERN ONTARIO; HUDSON ROBERT H E; VIIRRE RUSSELL D
摘要:The present invention discloses an improved synthesis of ethyl N-[(2-Boc-amino)ethyl]glycinate and its hydrochloride salt. The synthesis is based on the reductive alkylation of Boc-ethylenediamine with ethyl glyoxylate hydrate and furnishes the title compound in near quantitative yield and high purity without chromatography. This compound is suitable, as is, for the synthesis peptide nucleic acid monomers. Further, conversion to the hydrochloride salt provides a stable, non-hygroscopic solid that is a convenient form for handling and storage.

专利号:WO-9707129-A1
优先权日:1995-08-18
标题 :Solution synthesis of peripheral acting analgesic opioid tetrapeptides
发明人：RINALDI NICHOLAS
权利人:IAF BIOCHEM INT; RINALDI NICHOLAS
摘要:This invention provides a bulk scale process for the solution synthesis of enantiomerically pure peripherally acting analgesic opioid tetrapeptides corresponding to formula (I): Tyr-(D)R1-R2-R3-NH2, where R1 is Ala or Arg; R2 is Phe or Phe(p-F); and R3 is Phe or Phe(p-F). A new and unique multi-step process is disclosed comprising the joining of two dipeptides using standard solution phase synthesis techniques, but adjusting the individual factors (e.g., solvents, activating agents, neutralizing agents etc.), to minimize racemization of the second amino acid. Tremendous cost efficiencies are achieved due to elimination of traditional sequential blocking-deblocking cycles and multiple chromatographic purification steps, which also enables these simple kilogram quantity methods to be scaled up to commercial production.