CAS: 60134-26-1; (2R,3S)-2-(Hydroxymethyl)-5-Methoxytetrahydrofuran-3-Ol

相似化合物

863396-37-6 51255-17-5 144301-84-8

上下游产品

2-Deoxy-D-ribose methanol 2-deoxy-D-ribose (2R,3S)-2-(hydroxymethyl)tetrahydrofuran-3-ol methyl 2-deoxy-3,5-di-O-p-toluenesulfonyl-D-erythro-pentofuranoside methyl 2-deoxy-β-D-erythro-pentopyranoside 3,5-di-O-acetyl-2-deoxy-α/β-D-ribofuranoside methyl 3,5-di-O-benzyl-2-deoxy-D-ribofuranoside

2-脱氧-Beta-D-赤式-呋喃戊糖 以95%的收率获得产物甲基-2-脱氧-D-核糖
参考文献:A Concise Synthesis Of (R)-Hydroxy-E,Z-Diene Fatty Acids: Preparation Of 12(R)-Hete,Tetranor-12(R)-Hete,And 13(R)-Hode
标题:A Concise Synthesis Of (R)-Hydroxy-E,Z-Diene Fatty Acids: Preparation Of 12(R)-Hete,Tetranor-12(R)-Hete,And 13(R)-Hode
摘要:Chiral E-Enals Derived From Functionalized 2-Deoxy-D-Ribofuranoses By Ylide-Induced Beta-Elimination Were Exploited For The Synthesis Of Fatty Acid Metabolites Containing The (R)-Hydroxy-E,Z-Diene Subunit.
DOI:10.1016/s0040-4039(00)79912-6

专利信息

专利号:US-5948903-A
优先权日:1991-01-11
标题:Synthesis of 3-deazapurines
发明人：COOK P DAN; ACEVEDO OSCAR L; ANDREWS ROBERT S
权利人:ISIS PHARMACEUTICALS INC
摘要:This invention relates to compounds based on the 3-deazapurines ring system and to methods for making such compounds. The invention also generally relates to the field of 'antisense' agents, agents that are capable of specific hybridization with a nucleotide sequence of an RNA. The 3-deazapurine-containing compounds of this invention can be useful for modulating the activity of RNA when incorporated into oligonucleotides. Oligonucleotides and their analogs are used for a variety of therapeutic and diagnostic purposes, such as treating diseases, regulating gene expression in experimental systems, assaying for RNA and for RNA products through the employment of antisense interactions with such RNA, diagnosing diseases, modulating the production of proteins and cleaving RNA in site specific fashions.

专利号:US-5116741-A
优先权日:1988-04-12
标题 :Biosynthetic uses of thermostable proteases
发明人：BRYAN PHILIP N; PANTOLIANO MICHAEL W; ROLLENCE MICHELE L; WONG CHI H
权利人:GENEX CORP
摘要:The invention relates to the novel use of mutants of subtilisin in organic syntheses reactions in non-native environments. Especially the invention relates to methods for the use of mutant subtilisins in organic solvents for the catalysis of reactions involving ester formation and cleavage, including acylations and deacylations, and amidations and deamidations. The methods provide novel strategies which are useful in the synthesis of deoxynucleosides, dideoxynucleosides, peptides, sugars and the like.

专利号:US-5585252-A
优先权日:1988-08-30
标 题 :Enantio- and regioselective synthesis of organic compounds using enol esters as irreversible transacylation reagents
发明人：WONG CHI-HUEY; WANG YI-FONG; HENNEN WILIAM J
权利人:SEARLE & CO
摘要:A process for irreversible regio- and stereoselective enzyme catalyzed acylation of alcohols using enol esters as acylating reagents is disclosed. The present invention permits the selective modification of hydroxyl group(s) of chiral and meso alcohols, including sugars, organometallics, and glycosides. The enol freed upon transesterification rapidly tautomerizes to the corresponding volatile aldehyde or ketone thereby preventing the reverse reaction from occurring.

专利号:US-5750692-A
优先权日:1990-01-11
标 题 :Synthesis of 3-deazapurines
发明人：COOK P DAN; ACEVEDO OSCAR L; ANDREWS ROBERT S
权利人:ISIS PHARMACEUTICALS INC
摘要:This invention relates to compounds based on the 3-deazapurines ring system and to methods for making such compounds. The invention also generally relates to the field of 'antisense' agents, agents that are capable of specific hybridization with a nucleotide sequence of an RNA. The 3-deazapurine-containing compounds of this invention can be useful for modulating the activity of RNA when incorporated into oligonucleotides. Oligonucleotides and their analogs are used for a variety of therapeutic and diagnostic purposes, such as treating diseases, regulating gene expression in experimental systems, assaying for RNA and for RNA products through the employment of antisense interactions with such RNA, diagnosing diseases, modulating the production of proteins and cleaving RNA in site specific fashions.

专利号:EP-2883866-A1
优先权日:2012-08-13
标题 :INTERMEDIATE FOR SYNTHESIS OF 1-(2-DEOXY-2-FLUORO-4-THIO-beta-D-ARABINOFURANOSYL) CYTOSINE, INTERMEDIATE FOR SYNTHESIS OF THIONUCLEOSIDE, AND METHODS FOR PRODUCING THESE INTERMEDIATES

专利号:WO-2014027658-A1
优先权日:2012-08-13
标题 :INTERMEDIATE FOR SYNTHESIS OF 1-(2-DEOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL) CYTOSINE, INTERMEDIATE FOR SYNTHESIS OF THIONUCLEOSIDE, AND METHODS FOR PRODUCING THESE INTERMEDIATES