CAS: 7417-21-2; 2-(3,4-Dimethoxyphenyl)Ethanol

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CAS号93-40-3 3,4-二甲氧基苯乙酸 | CAS号75-21-8 环氧乙烷 | CAS号2859-78-1 3,4-二甲氧基溴苯 | CAS号15964-79-1 3,4-二甲氧基苯乙酸甲酯 | CAS号5703-21-9 (3,4-二甲氧基苯基)乙醛 | CAS号120-20-7 3,4-二甲氧基苯乙胺 | CAS号186581-53-3 重氮甲烷 | CAS号10597-60-1 3,4-二羟基苯乙醇 | CAS号14617-41-5 Benzeneethanol,... | CAS号102-32-9 3,4-二羟基苯乙酸 | CAS号14617-41-5 Benzeneethanol,... | CAS号14165-67-4 N-(3,4-Dimethox... | CAS号22506-58-7 1H-2-Benzopyran... | CAS号220556-03-6 4-(2-溴乙基)-1,2-苯二酚 | CAS号120-14-9 藜芦醛； 3,4-二甲氧基苯甲醛 | CAS号5963-51-9 Benzene, 1,1'-(... | CAS号34577-42-9 2-Methyl-4-(3,4... | CAS号27160-08-3 4-(2-chloroethy... | CAS号2107-70-2 3-(3,4-二甲氧基苯)丙酸 | CAS号93-40-3 3,4-二甲氧基苯乙酸

3,4-二甲氧基苯乙酸甲酯置于lithium Aluminium Tetrahydride体系中,用 四氢呋喃 作为反应溶剂,以100 %的收率获得产物3,4-二甲氧基苯乙醇
参考文献:非核苷类 Sars-Cov-2 Rdrp 抑制剂的设计,合成,对接和生化表征
标题:非核苷类 Sars-Cov-2 Rdrp 抑制剂的设计,合成,对接和生化表征
摘要:严重急性呼吸系统综合症冠状病毒 2 (Sars-Cov-2) 已引起全球大流行.鉴定有效的抗病毒药物仍然是迫切的医疗需求.在这种情况下,我们在这里报告了 17 种新的 1,4-苯并吡喃酮衍生物,这些衍生物的设计,合成和表征具有阻断 Rna 依赖性 Rna 聚合酶 (Rdrp) 的能力,这是抗病毒药物发现的一个有希望的目标.该化合物系列代表了开发 Rdrp 非核苷抑制剂的非常好起点.化合物4,5和8是最有前途的候选药物,具有非常好的抑制 Rdrp 的效力,在体外得到改善与初始命中相比的药代动力学,对正常细胞 (Hek-293) 没有细胞毒性作用.化合物8 (Arn25592) 作为最有前途的抑制剂脱颖而出.我们的结果表明,这种新的 1,4-苯并吡喃酮衍生物化学类别值得进一步探索,以开发用于治疗 Sars-Cov-2 和其他潜在病毒的新型有效抗病毒药物.
DOI:10.1016/j.Bmc.2023.117179

专利信息

专利号:US-8618311-B2
优先权日:2005-06-15
标题:Synthetic processes for the preparation of aminocyclohexyl ether compounds
发明人：JUNG GRACE; YEE JAMES GEE KEN; CHOU DOUG TA HUNG; PLOUVIER BERTRAND M C
权利人:JUNG GRACE; YEE JAMES GEE KEN; CHOU DOUG TA HUNG; PLOUVIER BERTRAND M C; CARDIOME PHARMA CORP
摘要:This invention is directed to stereoselective synthesis of compounds of formula (I) or formula (II): n nor a pharmaceutically acceptable salt, ester, amide, complex, chelate, clathrate, solvate, polymorph, stereoisomer, metabolite or prodrug thereof; wherein R 3 , R 4 and R 5 are defined herein. Compounds of formula (I) and formula (II) are known to be useful in treating arrhythmias.

专利号:US-2004053999-A1
优先权日:1997-09-17
标题 :Novel compounds and methods for synthesis and therapy
发明人：BISCHOFBERGER NORBERT W; DAHL TERRENCE C; HITCHCOCK MICHAEL J M; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; MILLS ROGER G; WILLIAMS MATTHEW A
摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

专利号:US-6225341-B1
优先权日:1995-02-27
标 题:Compounds and methods for synthesis and therapy
发明人：BISCHOFBERGER NORBERT W; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; WILLIAMS MATTHEW A
权利人:GILEAD SCIENCES INC
摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

专利号:US-2012016390-A1
优先权日:2010-07-16
标 题 :Bioadhesive compounds and methods of synthesis and use
发明人：LEE BRUCE P; MURPHY JOHN L; VOLLENWEIDER LAURA; DALSIN JEFFREY L; LYMAN ARINNE N
权利人:LEE BRUCE P; MURPHY JOHN L; VOLLENWEIDER LAURA; DALSIN JEFFREY L; LYMAN ARINNE N; KNC NER ACQUISITION SUB INC
摘要:The invention describes new synthetic medical adhesives and antifouling coatings which exploit the key components of natural marine mussel adhesive proteins.

专利号:US-6492529-B1
优先权日:2000-01-18
标题 :Bis pyrazole-1H-pyrazole intermediates and their synthesis
发明人：KAPADIA SURESH R; SONG JINHUA J; YEE NATHAN K
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:Disclosed are aromatic heterocyclic compounds of the formula (I) wherein Ar 1 , Ar 2 , L, Q and X are described herein, and intermediate compounds useful for making such compounds. The compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. n Also disclosed are processes of making compounds of the formula (I), their intermediates and processes of making such intermediates, including bis pyrazole-1H-pyrazole intermediates of the formula: n wherein Alk, R x and R z are described herein.

专利号:US-5763599-A
优先权日:1994-12-16
标题:Nucleoside derivatives with photolabile protective groups
发明人：PFLEIDERER WOLFGANG; GIEGRICH HEINER
权利人:PFLEIDERER WOLFGANG
摘要:The invention relates to nucleoside derivatives having photolabile protective groups of the general formula (I) ##STR1## in which R 1 â•?H, NO 2 , CN, OCH 3 , halogen or alkyl or alkoxyalkyl having 1 to 4 C atoms n R 2 â•?H, OCH 3 n R 3 â•?H, F, Cl, Br, NO 2 n R 4 â•?H, halogen, OCH 3 , or an alkyl radical having 1 to 4 C atoms n R 5 â•?H or a usual functional group for preparing oligonucleotides n R 6 â•?H, OH, halogen or XR 8 , where Xâ•?O or S and R 8 represents a protective group usual in nucleotide chemistry, n B=adenine, cytosine, guanine, thymine, uracil, 2,6-diaminopurin-9-yl, hypoxanthin-9-yl, 5-methylcytosin-1-yl, 5-amino-4-imidazolcarboxamid-1-yl, or 5-amino-4-imidazolcarboxamid-3-yl, where in the case of B=adenine, cytosine or guanine, the primary amino function optionally exhibits a permanent protective group. n These derivatives may be used for the light-controlled synthesis of oligonucleotides on a DNA chip.