CAS: 83881-52-1; 2-(2-(4-((4-Chlorophenyl)(Phenyl)Methyl)Piperazin-1-yl)Ethoxy)Acetic Acid Dihydrochloride

上下游产品

CAS号83881-51-0 西替利嗪 | CAS号109806-71-5 4-氯双苯基甲哌乙醇 | CAS号3926-62-3 氯乙酸钠 | CAS号83881-37-2 西替利嗪酰胺 | CAS号343781-29-3 (RS)-N,N-diethy... | CAS号343781-30-6 (RS)-N,N-dially... | CAS号119-56-2 4-氯二苯甲醇 | CAS号134-83-8 4-氯二苯氯甲烷 | CAS号134-85-0 4-氯二苯甲酮 | CAS号83881-37-2 西替利嗪酰胺 | CAS号83881-46-3 左西替利杂质8 | CAS号83881-51-0 西替利嗪

2-(2-(4-((4-Chlorophenyl)(Phenyl)Methyl)Piperazin-1-yl)Ethoxy)Acetaldehyde 在 Potassium Dihydrogenphosphate,磷酸,双氧水,盐酸体系中,用 二氯甲烷,二甲基亚砜,丁酮作为反应溶剂,反应 8.0H,以86%的收率获得cetirizine DihydroChloride
参考文献:一种合成盐酸西替利嗪的工艺
标题:一种合成盐酸西替利嗪的工艺
摘要:一种合成盐酸西替利嗪的新的工艺.该工艺以羟嗪为原料,首先将羟嗪氧化为醛基物,之后该醛基物再经进一步氧化为西替利嗪,最后经成盐纯化得到盐酸西替利嗪.该合成方法总收率高达80%以上.同时该合成方法具有操作简单,生产周期短,能耗少,成本低,三废少的特点,适合大规模工业化生产.

专利信息

专利号:US-7619085-B2
优先权日:2005-03-03
标 题 :Pyroglutamate salts and their use in the optical resolution of intermediates for the synthesis of dextrocetirizine and levocetirizine
发明人：PALACIO MAGALI; ATES CELAL
权利人:UCB PHARMA SA
摘要:The present invention relates to (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide-(S)-pyrrolidone-5-carboxylic acid salt; (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide-(S)-pyrrolidone-5-carboxylic acid salt; (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide-(R)-pyrrolidone-5-carboxylicacid salt; or (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxycetamide-(R)-pyrrolidone-5-carboxylic salt. The present invention relates also to a process for preparing (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide (I) and (R)-2-[4-(4-chlorobenzhydryl) piperazin-1-yl]-ethoxyacetamide (II) by chemical resolution of a mixture. These compounds are respectively intermediates for the synthesis of dextrocetirizine and levocetirizine.

专利号:US-2025206743-A1
优先权日:2022-03-25
标 题:Tyk2 inhibitor synthesis and intermediates thereof
发明人：MASSE CRAIG E; PHADKE AVINASH S; LAWSON JON P; LEVY STUART; YANG XIAOWEI; WU GUISHENG; FAN SHUFENG
权利人:TAKEDA PHARMACEUTICALS CO
摘要:Described herein are methods of synthesis of a tyrosine-protein kinase 2 (TYK2) inhibitor and to intermediate compounds of the synthesis and methods of making the intermediates. Also provided are pharmaceutically acceptable compositions including compounds prepared by the synthetic method and methods of treating disorders using the same.

专利号:US-4894385-A
优先权日:1985-01-16
标 题:Imidazole derivatives as inhibitors of TXA2 synthesis
发明人：KAWAMOTO ISAO; ENDO ROKURO; MATSUDA KEIICHI; USHIYAMA SHIGERU; OSHIMA TAKESHI
权利人:SANKYO CO
摘要:Compounds of formula (I): ##STR1## (wherein n is 0, 1 or 2 and R 1 , R 2 , R 4 , R 5 , R 6 , X, Y and Z are a variety of groups and atoms) have the ability to inhibit the synthesis of thromboxane A 2 and hence are useful in the treatment or prophylaxis of thrombotic conditions.

专利号:US-12295961-B2
优先权日:2009-12-31
标 题:Modulation of solubility, stability, absorption, metabolism, and pharmacokinetic profile of lipophilic drugs by sterols
发明人：DHINGRA OM
权利人:MARIUS PHARMACEUTICALS INC
摘要:A formulation for drug delivery, providing enhanced modulation of solubility, stability, absorption, metabolism, and/or pharmacokinetic profile of a lipophilic therapeutic agent by formulation with sterols and/or sterol esters, resulting in higher bioavailability of a therapeutic agent administered to a subject in need of such therapeutic agent. The formulation contains a therapeutic agent and a sterol or sterol ester, and can, optionally, further contain a solubilizer and/or an enhancing agent. Also described are pharmaceutical compositions containing the formulations and methods of making and methods of using the formulations and pharmaceutical compositions. Formulations of the disclosure can be constituted to minimize the synthesis of dihydrotestosterone when the therapeutic agent includes testosterone or testosterone esters.

专利号:US-7807837-B2
优先权日:2004-05-07
标 题 :Scalable synthesis of imidazole derivatives
发明人：JONES TODD K; MANI NEELAKANDHA
权利人:JANSSEN PHARMACEUTICA NV
摘要:Imidazole derivatives, compositions containing them, methods of preparing them, including regioselective scale-up synthetic methods, and methods of using them.

专利号:WO-2022145215-A1
优先权日:2020-12-28
标题:Video selection-synthesis device, control method therefor, and management device
发明人：TAKABAYASHI KAZUHIKO; YAMAGISHI YASUAKI
权利人:SONY GROUP CORP
摘要:The present disclosure relates to a video selection-synthesis device, a control method therefor, and a management device, with which it is possible to appropriately realize a production switcher function.　The video selection-synthesis device comprises: a selection unit for making settings based on the format characteristic information of video streams outputted by a plurality of video sources and selecting one or a plurality of videos from among the videos of video streams supplied from each of the plurality of video sources; and a composition unit for composing one video screen using the one or plurality of videos selected by the selection unit. The technology of the present disclosure can be applied, for example, to a content production system, etc., that delivers, taking advantage of a 5G network, content such as a sports or entertainment live performed at an event venue.