CAS: 93107-08-5; Ciprofloxacin (Hydrochloride)

• 英文名称Ciprofloxacin (Hydrochloride)
• 中文名称环丙沙星盐酸盐
• IUPAC名称cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid, monohydrochloride
• 其它别名1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid hydr°Chloride
• CAS编号93107-08-5
• MFCD编号:MFCD00079044
• EINECS号:642-985-5
• 分子式:C17H18FN3O3.HCl
• 分子量:367.8
• 产品CID: 1969770
• 同类组份化合物CAS85721-33-1 (free base)86393-32-0 (HCl hydrate)86483-48-9 (xHCl)93107-08-5 (HCl)96186-80-0 (lactate)97867-33-9 (lactate)
• 产品分类原料药 → 抗生素类药物

• 相似结构搜索
• 产品信息参考;
• InChIKey: DIOIOSKKIYDRIQ-UHFFFAOYSA-N
• InChI=1S/C17H18FN3O3.ClH/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24;/h7-10,19H,1-6H2,(H,23,24);1H…
• 计算化学: 氢键受体数7.0氢键供体数3.0可旋转键数3.0

物理性质

• 熔点>300 °C
• PSA:74.57
• LogP:2.7791
• 溶解性Insoluble In Etoh; ≥33.87 mg/mL In H2O; ≥9.34 mg/mL In DMSO With Ultrasonic
• 外观形态白色至类白色结晶性固体
• 储存条件密封, 常温干燥保存
• 产品应用该品是喹诺酮类抗菌药的优秀代表之一,由德国拜耳药厂于1983年研制成功,喹诺酮类抗菌药的第一代以萘啶酸为代表,第二代以吡哌酸为代表,第三代以氟哌酸为代表.环丙氟哌酸抗菌谱广,抗菌活性强,对革兰氏阳性菌和革兰氏阴性菌都有效,对绿脓杆菌也有效,不良反应少.是国际市场上销售额很大的药物品种,国内生产发展迅速.
• 性质描述白色或微黄色结晶性粉末.熔点255-257°C(分解).

MSDS等安全信息

• GHS象形图
• GHS符号GHS07 & GHS09;
  注释: Exclamation mark & Environment
• 危险类别严重眼刺激 类别2
  水生慢性毒性 类别1
  呼吸道致敏 类别1
  皮肤致敏 类别1
  水生急性毒性 类别1
  特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
• 警示词Warning(警告)
• 危险描述H319 |造成严重眼刺激.
  H410 |对水生生物毒性极大并具有长期持续影响.
  H334 |吸入可能引起过敏或哮喘症状或呼吸困难.
  H317 |可能引起皮肤过敏反应.
  H400 |对水生生物毒性极大.
  H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
• 防范说明P261-P305+P351+P338
• 安全声明24/25

欧盟法规

合成工艺路线路线简述

• 合成目标产物 Ciprofloxacin Hydrochloride 主要起始原料 Ciprofloxacin
• 86393-33-1 = 93107-08-5
  反应条件:1.1 Reagents: Sodium Methoxide Solvents: Isoamyl Alcohol; 7 H,130 °C1.2 Reagents: Hydrochloric Acid Solvents: Ethanol,Water
  标题:Synthesis Technology Of Ciprofloxacin Hydrochloride
  作者:Li,Yu-Shan
  参考文献:Yingyong Huagong 日期:2013 卷标:42(2) 页码:287-290]
  
  93594-29-7 = 93107-08-5
  反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Ethanol,Water1.2 Reagents: Hydrochloric Acid Solvents: Water
  标题:Preparation Of Ciprofloxacin And Related Compounds
  参考文献:Canada]
  
  98349-25-8 = 93107-08-5
  反应条件:1.1 Reagents: Triethylamine Solvents: Dimethylformamide; Rt -> 90 °C; 90 °C1.2 Reagents: Sodium Hydroxide Solvents: Ethanol,Water; 2 H,Rt1.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 5 - 6
  标题:Synthesis Of A Library Of Ciprofloxacin Analogues By Means Of Sequential Organic Synthesis In Microreactors
  作者:Schwalbe,Thomas; Kadzimirsz,Daniel; Jas,Gerhard
  参考文献:Qsar & Combinatorial Science 日期:2005 卷标:24(6) 页码:758-768]
  
  86393-33-1 = 93107-08-5
  反应条件:1.1 15 Min,155 - 160 °C; 0.5 H,155 - 160 °C1.2 Reagents: Hydrochloric Acid Solvents: Ethanol,Water; Acidified,Cooled
  标题:Preparation Of Guanidine And Biguanidine Derivatives As Antiviral And Antimicrobial Agents
  参考文献:United States]
  
  = 93107-08-5 [标题:Reaction Conditions
  标题:Silver Nanoparticles Conjugated With Ciprofloxacin HCL To Combat Bacterial- Resistance Via Topical Drug Delivery System
  作者:Sharma,Mohit; Sharma,Rahul
  参考文献:World Journal Of Pharmacy And Pharmaceutical Sciences 日期:2019 卷标:8(10) 页码:611-623]
  
  = 93107-08-5 [标题:Reaction Conditions
  标题:Advanced Continuous Flow Platform For On-Demand Pharmaceutical Manufacturing
  作者:Zhang,Ping; Weeranoppanant,Nopphon; Thomas,Dale A.; Tahara,Kohei; Stelzer,Torsten; Et Al
  参考文献:Chemistry - A European Journal 日期:2018 卷标:24(11) 页码:2776-2784]
  
  = 93107-08-5 [标题:Reaction Conditions
  标题:Studies On Synthesis Of 2,4-Dichloro-5-Fluoro-Acetophenone As Intermediate Of Ciprofloxacin Hydrochloride
  作者:Zhang,Xin-Hua; Zhu,Zhi-Liang
  参考文献:Nantong Gongxueyuan Xuebao 日期:2004 卷标:3(3) 页码:48-50]
  
  = 93107-08-5 [标题:Reaction Conditions
  标题:Preparation Of Quinolonecarboxylates From Oxotetrahydroquinolines.
  参考文献:Canada]
  
  = 93107-08-5 [标题:Reaction Conditions
  标题:Trimethylsilyl Esters And Solvates Of Chelates Of Quinoline-3-Carboxylic Acids,And Their Preparation And Use In A Process For Quinolone Antibacterials.
  参考文献:Spain]
  
  86393-33-1 = 93107-08-5
  反应条件:1.1 Catalysts: Aluminum Acetate Solvents: Water; 8 H,110 °C1.2 Reagents: Sodium Hydroxide Solvents: Water; 0.5 H,110 °C
  标题:Method For Recovering Piperazine After Condensation Reaction Of Piperazine During Preparation Process Of Quinolone Drug
  参考文献:China]
  
  = 93107-08-5
  反应条件:1.1 Reagents: Trimethylethoxysilane Solvents: Acetonitrile; Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; < Ph 1,0 °C; 4 H,Heated
  标题:Green Preparation Of Quinolone Carboxylic Acid Derivative Or Phthalazinone Carboxylic Acid Derivative
  参考文献:China]
  
  93107-30-3 = 93107-08-5
  反应条件:1.1 Solvents: N-Ethyl-2-Pyrrolidone; Rt -> 80 °C; 3 H,70 - 80 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; 20 °C -> 85 °C; 0.5 H,85 °C
  标题:Preparation Of Ciprofloxacin Hydrochloride
  参考文献:China]
  
  86393-33-1 = 93107-08-5
  反应条件:1.1 20 Min1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 7,0 °C1.3 Reagents: Hydrochloric Acid Solvents: Water; 80 °C
  标题:An Expeditious Synthesis Of Quinolone Antibacterials
  作者:Heravi,Majid M.; Oskooie,Hossein A.; Motamedi,Radineh; Ghassemzadeh,Mitra
  参考文献:Heterocyclic Communications 日期:2005 卷标:11(5) 页码:423-426]
  
  86393-33-1 = 93107-08-5
  反应条件:1.1 Catalysts: Iron Chloride (Fecl3) Solvents: Pyridine; Rt -> 120 °C; 8 - 12 H,110 - 120 °C; 120 °C -> 80 °C1.2 Reagents: Hydrochloric Acid Solvents: Methanol,Water; 2 H,45 - 50 °C
  标题:Improved Process For The Preparation Of Ciprofloxacin And Its Acid Addition Salts
  参考文献:India]
  
  85721-33-1 = 93107-08-5
  反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Acetone,Water; Ph 3,Rt
  标题:A Rapid Total Synthesis Of Ciprofloxacin Hydrochloride In Continuous Flow
  作者:Lin,Hongkun; Dai,Chunhui; Jamison,Timothy F.; Jensen,Klavs F.
  参考文献:Angewandte Chemie 日期:2017 卷标:56(30) 页码:8870-8873]
  
  85721-33-1 = 93107-08-5
  反应条件:1.1 Reagents: Aluminum Chloride Solvents: Ethanol; 15 H,Rt
  标题:Nmr And Ir Characterization Of The Aluminum Complexes Of Norfloxacin And Ciprofloxacin Fluoroquinolones
  作者:Chattah,Ana K.; Linck,Yamila Garro; Monti,Gustavo A.; Levstein,Patricia R.; Breda,Susana A.; Et Al
  参考文献:Magnetic Resonance In Chemistry 日期:2007 卷标:45(10) 页码:850-859]
  
  = 93107-08-5 [标题:Reaction Conditions
  标题:Preparation Of Fluoroquinolone Compounds As Antibiotic Resistance Breakers
  参考文献:World Intellectual Property Organization]
  
  = 93107-08-5 [标题:Reaction Conditions
  标题:Improved Process For The Preparation Of Ciprofloxacin And Its Acid Addition Salts
  参考文献:World Intellectual Property Organization]
  
  = 93107-08-5 [标题:Reaction Conditions
  标题:Isolation And Characterization Of Ciprofloxacin-HCL Crystals
  作者:Kakkar,A. P.; Singh,Manmohan; Mendiratta,Arun
  参考文献:Drug Development And Industrial Pharmacy 日期:1997 卷标:23(11) 页码:1063-1067]
  
  = 93107-08-5 [标题:Reaction Conditions
  标题:Synthesis Of Ciprofloxacin Hydrochloride Monohydrate
  作者:Li,Heping; Jiang,Tiancheng
  参考文献:Huaxue Yanjiu Yu Yingyong 日期:1996 卷标:8(2) 页码:292-294

海关参考信息

• 2905110000-甲醇
  2912110000-甲醛
  2915110000-甲酸
  2921211000-乙二胺
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
• 详情请参考：📖 海关编码查询和海关进出口税则

其他信息查阅

• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
• ➥ Globally Harmonized System
• ➥ REACH监管