CAS: 10167-97-2; 2-Amino-5-Methoxypyridine

相似化合物

89943-11-3 10201-71-5 110861-14-8

上下游产品

2-bromo-3-methoxy-6-nitropyridine 2-amino-5-iodopyridine methanol 5-bromo-2-pyridylamine pyridine6-methoxy-2-(4'-tolyl)imidazo1,2-apyridine 2-(4-bromophenyl)-6-methoxyimidazo[1,2-a]pyridine 2-bromo-5-methoxypyridine 2-(4-Chlorophenyl)-6-methoxyimidazo[1,2-a]pyridine

2-(2,5-二甲基-1H-吡咯-1-基)-5-甲氧基吡啶置于盐酸羟胺,三乙胺体系中,用 乙醇,水 用作溶剂,化学反应 20.0H,以100%的收率获得2-氨基-5-甲氧基吡啶
参考文献:Synthesis Of 2-Amino-5-Hydroxypyridine Via Demethoxylation
标题:Synthesis Of 2-Amino-5-Hydroxypyridine Via Demethoxylation
摘要:一种方便且高效的四步合成2-氨基-5-羟基吡啶的方法是通过在2,5-己二酮存在下对2-氨基-5-溴吡啶进行保护反应,得到5-溴-2-(2,5-二甲基-1H-吡咯-1-基)吡啶;然后用甲基钠进行甲氧基化反应,得到5-甲氧基-2-(2,5-二甲基-1H-吡咯-1-基)吡啶;接着用氢氧胺盐酸盐进行去保护反应,生成2-氨基-5-甲氧基吡啶;最后用95%的硫酸进行去甲基化,最终得到标题化合物,总体收率为45%.
Doi:10.14233/ajchem.2016.19692

专利信息

专利号:US-5001136-A
优先权日:1990-06-07
标 题 :Leukotriene-synthesis-inhibiting 2-substitutedmethylamino-5-(hydroxy or alkoxy)pyridines
发明人：WALKER FREDERICK J
权利人:PFIZER
摘要:2-substitutedmethylamino-amino 5-(hydroxy or alkoxy) pyridines and derivatives thereof are disclosed. The compounds are inhibitors of leukotriene synthesis and are therefore useful for the treatment of pulmonary, inflammatory, dermatological, allergic and cardiovascular diseases.

专利号:US-8518952-B2
优先权日:2008-08-06
标题 :6 substituted 2-heterocyclylamino pyrazine compounds as CHK-1 inhibitors
发明人：BRAGANZA JOHN FREDERICK; COLLINS MICHAEL RAYMOND; KATH JOHN CHARLES; NINKOVIC SACHA; LI HUI; RICHTER DANIEL TYLER
权利人:BRAGANZA JOHN FREDERICK; COLLINS MICHAEL RAYMOND; KATH JOHN CHARLES; NINKOVIC SACHA; LI HUI; RICHTER DANIEL TYLER; PFIZER
摘要:The present invention is directed to compounds of formula (I), n nand pharmaceutically acceptable salts thereof, their synthesis, and their use as CHK-1 inhibitors.