CAS: 119623-66-4; 2-(Pyrrolidin-1-yl)Ethan-1-Ol 2-(2-((2,6-Dichlorophenyl)Amino)Phenyl)Acetate Salt

N-(2-羟乙基)-吡咯烷,Cataflam置于盐酸体系中,用 水,乙酸乙酯 用作溶剂,化学反应生成双氯芬酸吡咯烷乙醇盐
参考文献: Process For The Preparation Of Diclofenac Epolamine[fr] Procédé De Préparation De Diclofénac épolamine
标题: Process For The Preparation Of Diclofenac Epolamine[fr] Procédé De Préparation De Diclofénac épolamine
摘要:本发明涉及一种制备盐酸地氯芬酸依泊拉明的方法,包括以下步骤:A) 在水溶剂中用氢氧化钠或氢氧化钾与1-(2,6-二氯苯基)-2-吲哚酮反应,从而获得盐酸地氯芬酸钠或钾;B) 将获得的盐酸地氯芬酸钠或钾溶解在包括水和乙酸乙酯,异丁基甲酮,甲苯,异丁酸乙酯,正丁酸乙酯,正丙酸乙酯,异丙酸乙酯在内的有机溶剂混合物中;C) 添加强酸以得到地氯芬酸并去除水相;D) 脱水剩余的有机溶剂相;E) 添加1-(2-羟乙基)-吡咯烷.

专利信息

专利号:US-10022366-B2
优先权日:2013-04-23
标 题:Extending and maintaining micropore viability of microneedle treated skin with lipid biosynthesis inhibitors for sustained drug delivery
发明人：STINCHCOMB AUDRA L; GHOSH PRIYANKA
权利人:STINCHCOMB AUDRA L; GHOSH PRIYANKA; UNIV MARYLAND; UNIV KENTUCKY RES FOUND
摘要:Microneedles and their use as a physical skin permeation enhancement technique facilitate drug delivery across the skin in therapeutically relevant concentrations. Micropores created in the skin by MNs reseal because of normal healing processes of the skin, thus limiting the duration of the drug delivery window. Pore lifetime enhancement strategies can increase effectiveness of MNs as a drug delivery mechanism by prolonging the delivery window. Fluvastatin (FLU) was used to enhance pore lifetime by inhibiting the synthesis of cholesterol, a major component of the stratum corneum lipids. The skin recovered within a 30-45-min time period following the removal of occlusion, and there was no significant irritation observed due to the treatment compared to the control sites. Thus, it can be concluded that localized skin treatment with FLU can be used to extend micropore lifetime and deliver drugs for up to 7 days across MN-treated skin.