CAS: 124-26-5; Octadecanamide

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124-30-1 1838-08-0 629-54-9

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CAS号112-76-5 十八碳酰氯 | CAS号57-11-4 硬脂酸 | CAS号638-65-3 硬脂腈 | CAS号77165-65-2 °Ctadecanoyl azide | CAS号120158-01-2 tert-butyl stea... | CAS号57-13-6 尿素 | CAS号53422-22-3 2,2,4,4,6-五甲基-六氢嘧啶 | CAS号144-55-8 碳酸氢钠 | CAS号124-40-3 二甲胺 | CAS号2733-91-7 (9Z)-11-[(2S,3R... | CAS号4130-54-5 硬脂酰肼 | CAS号3370-35-2 N-羟甲基硬脂酰胺 | CAS号112-69-6 十六烷基二甲基叔胺 | CAS号124-28-7 十八烷基二甲基叔胺 | CAS号14727-68-5 Z-N,N-二甲基-9-十八烯胺 | CAS号4200-95-7 1-氨基十七烷 | CAS号2955-56-8 3-二十烷酮 | CAS号6786-36-3 十八烷基苯酮 | CAS号638-66-4 十八醛

硬脂酸置于碳酸氢铵,Formamide体系中,化学反应 0.15H,以82%的收率获得硬脂酰胺
参考文献:羧酸铵盐微波辅助脱水制得的酰胺
标题:羧酸铵盐微波辅助脱水制得的酰胺
摘要:伯酰胺的制备是有机化学中的一个重要反应.报道的这种转化方法包括 A) 酸与氨的直接反应;B) 相应酸酐或酯的氨解和 C) 酰氯与气态或氨水的反应.除非酯具有非常好的离去基团,否则酯的氨解通常是缓慢的反应.* Litjens 及其同事开发了脂肪酶催化的羧酸与铵盐作为氨源的酰胺化反应.尽管此过程温和且具有选择性,但耗时(17 天).3 羧酸与氨的直接酰胺化需要苛刻的条件(20O0,7 Bar 和无水氨).微波加热及其在有机合成中的应用受到广泛关注,近期综述如下:我们在此报告了在微波辐射下从甲酰胺中的羧酸铵盐制备伯酰胺的直接和快速方法.据我们所知,这是利用微波技术快速合成伯酰胺的第一份报告.
Doi:10.1080/00304940209355747

专利信息

专利号:US-5646319-A
优先权日:1995-06-23
标题:Synthesis of N-acyl-N-alkylcarboxylates
发明人：LETTON JAMES CAREY; MILLER LARRY EUGENE
权利人:PROCTER & GAMBLE
摘要:Chemical synthesis of N-acyl-N-alkylcarboxylates through oxidation of substituted amides formed from carboxylic acid esters and an N-alkyl-N-alkanolamine.

专利号:US-5188769-A
优先权日:1992-03-26
标 题:Process for reducing the levels of fatty acid contaminants in polyhydroxy fatty acid amide surfactants
发明人：CONNOR DANIEL S; SCHEIBEL JEFFREY J; MURCH BRUCE P; MAO MARK H; GOSSELINK EUGENE P; SEVERSON JR ROLAND G
权利人:PROCTER & GAMBLE
摘要:The synthesis of polyhydroxy fatty acid amide surfactants exemplified by the compound C11H23C(O)N(CH3)CH2[CHOH]4CH2OH by reacting a fatty acid ester with an N-alkyl sugar amine can result in contamination of the product surfactant by residual sources of fatty acids. These residual fatty acids may be unacceptable in high sudsing detergent compositions, such as dishwashing liquids, especially with Ca or Mg cations. The process of this invention reacts such contaminants with alkyl amines or, especially, ethanolamine, to convert them into fatty alkyl- or alkanolamides, which are quite acceptable in fully-formulated detergent compositions for home or industrial use.

专利号:WO-9522519-A1
优先权日:1994-02-17
标题 :Synthesis of polyhydroxy fatty acid amides from triglycerides
发明人：SCHEIBEL JEFFREY JOHN; REILMAN RANDALL THOMAS; SHERMAN JOE FREDERICK
权利人:PROCTER & GAMBLE
摘要:Fats and oils such as hardened palm kernel oil are reacted directly with N-substituted polyhydroxy amines to provide high yields of N-substituted polyhydroxy fatty acid amide surfactants having improved odors and low fatty acid content. Hardened palm kernel oil is reacted with N-methylglucamine in the presence of an ethoxylated alcohol, but in the absence of methanol solvent, using sodium propylene glycolate catalyst to provide the mixed corresponding fatty acid amide of N-methylglucamine.

专利号:US-2005080260-A1
优先权日:2003-04-22
标 题 :Preparation of prodrugs for selective drug delivery
发明人：MILLS RANDELL L; WU GUO-ZHANG
摘要:Synthesis of a chemical compound having the formula A-B-C that may serve for applications such as drug delivery where A is a chemiluminescent, moiety, B is a photochromic moiety, and C is a biologically active moiety where A-B-C may serve as a prodrug. Novel synthetic methods of the present invention to form the prodrug comprised the steps of (1) forming a benzophenone, (2) forming a diaryl ethylene, (3) attaching a phthalimide moiety to at least one of the aryl groups of the ethylene to form a phthalimide-ethylene conjugate, (4) condensing two ethylene-phthalimide conjugates to form a phthalimide-pentadiene conjugate, (5) converting the phthalimide to the phthalhydrazide by reaction with hydrazine to form a carrier compound according to the present invention, and (6) reacting the carrier compound with an nucleophilic moiety of the drug to form the corresponding prodrug. Alternatively the carrier can be prepared by using the halo-substituted diaryl ethylene to make the corresponding cationic leuco dye-like compound with known methods. The cationic compound then is protected by reacting with a nucleophile and coupled with the aminophathalimide by palladium-catalyzed amination to form the protected phthalimide-pentadiene conjugate. The latter is refluxed with hydrazine to convert its phthalimide to the phthalhydrazide and acidified to give the carrier. An additional aspect of the present invention relates to the use of these compounds as antiviral agents for the treatment of viral infections such as HIV and as anticancer agents for the treatment of cancers such as bowel, lung, and breast cancer.

专利号:US-4780542-A
优先权日:1983-09-26
标 题:Process for the synthesis of esters and amides of carboxylic acids
发明人：LALEZARI IRAJ
权利人:MONTEFIORE MED CENTER
摘要:The invention relates to the preparation of an ester or an amide from an anhydride with an alcohol or an amine, wherein the anhydride is first prepared by reacting an acid and an alkyl chloroformate in a 100% aqueous medium, that is, 100% water.

专利号:EP-0082618-B1
优先权日:1981-12-23
标题 :Method of preparing a polymeric coating composition
摘要:A method of preparing a storage-stable one-part reactive liquid thermal curing polymeric coating composition from an isocyanate-functional polymeric compound which has a substantial portion of its isocyanate groups masked with an isocvanate masking agent, and a crosslinking agent which is substantially insoluble in aprotic solvents. These liquid compositions are homogeneous even when free of solvents. Preferably the crosslinking agent is a crystalline polyol. The method involves the synthesis of a solubilizing oligomer which is formed by the partial reaction of the crosslinking agent and the unmasked isocyanate-functional polymeric compound. The thermal curing of these compositions results in polymeric coatings which possess superior physical properties. These cured coatings are particularly useful in the manufacture of retroreflective sheeting.