CAS: 1416134-48-9; (2S,5R)-Ethyl 5-((Benzyloxy)Amino)Piperidine-2-Carboxylate Oxalate

相似化合物

1416134-47-8 2380736-50-3 1416134-47-8

Boc-L-焦谷氨酸乙酯置于sodium Tetrahydroborate,甲烷磺酸,硫酸,Potassium Tert-Butylate,丙酸体系中,用 四氢呋喃,二甲基亚砜,乙酸乙酯 用作溶剂,化学反应生成(2S,5R)-5-[(苯基甲氧基)氨基]-2-哌啶羧酸乙酯草酸盐
参考文献:Processes For Preparing Heterocyclic Compounds Including Trans-7-Oxo-6-(Sulphooxy)-1,6-Diazabicyclo[3,2,1]octane-2-Carboxamide And Salts Thereof
标题:Processes For Preparing Heterocyclic Compounds Including Trans-7-Oxo-6-(Sulphooxy)-1,6-Diazabicyclo[3,2,1]octane-2-Carboxamide And Salts Thereof
摘要:本发明涉及化合物和制备化合物的方法,其中包括类似于trans-7-Oxo-6-(Sulphooxy)-1,6-Diazabicyclo[3,2,1]octane-2-Carboxamide及其盐(例如nxl-104)的化合物.

专利信息

专利号:WO-2025027521-A1
优先权日:2023-08-01
标题 :An improved process for the preparation of avibactam and intermediate thereof
发明人：DHAVARIA SANDEEP; HANDA VISHAL; SHARMA SUNEEL KUMAR; MEHTA ANSHU KUMAR; SINGH ADITYA NARAYAN; ABUL AZIM; GUPTA NITIN; SINGH GOVIND; CABRI WALTER
权利人:FRESENIUS KABI ONCOLOGY LTD
摘要:The present invention relates to an improved process for the preparation of Avibactam or a pharmaceutically acceptable salt thereof, particularly the present invention relates to process for the preparation of a bridged ester intermediate of Formula I, wherein R1 is a hydroxy protecting group which is a key intermediate for Avibactam or a pharmaceutically acceptable salt thereof. The present invention also relates to the crystalline form of intermediates used for the synthesis of Avibactam or a pharmaceutically acceptable salt thereof. The invention also provides improved processes for the preparation of Avibactam or a pharmaceutically acceptable salt, using the bridged ester compound of formula I prepared by the process of the present invention.

专利号:CN-120136775-A
优先权日:2025-02-26
标题 :High diastereoselectivity synthesis method of avibactam intermediate III