CAS: 145783-12-6; 2-(Propylthio)Pyrimidine-4,6-Diol

相似化合物

1979-98-2 381678-33-7 145783-12-6

上下游产品

CAS号107-08-4 1-碘丙烷 | CAS号91759-32-9 2-疏基-4,6-二羟基-嘧啶 | CAS号872-50-4 N-甲基吡咯烷酮(NMP) | CAS号504-17-6 2-硫代巴比妥酸 | CAS号274693-27-5 替卡格雷 | CAS号145783-14-8 4,6-二氯-5-硝基-2-丙硫基嘧啶 | CAS号145783-15-9 4,6-二氯 -2-(丙硫基)...

4,6-二羟基-2-巯基嘧啶,1-碘代丙烷置于n-甲基吡咯烷酮,Sodium Hydroxide体系中,用 水 用作溶剂,化学反应 0.37H,以84.64%的收率获得6-羟基-2-(丙基硫代)-4(3H)-嘧啶酮
参考文献:一种替格瑞洛的制备方法及其中间体
标题:一种替格瑞洛的制备方法及其中间体
摘要:本发明涉及一种替格瑞洛的制备方法及其中间体.本发明所提供的制备方法为:以式ⅷ化合物和式ⅶ化合物或其盐为原料进行反应,得到的中间体经脱丙酮叉保护基,脱任选取代的偶氮苯保护基,环合反应后,再与式ⅱ化合物或其盐反应,制备得替格瑞洛.本发明的制备方法具有步骤简短,总收率高,反应条件温和,后处理简便的特点,适合工业化生产.

专利信息

专利号:WO-2015067230-A1
优先权日:2013-11-08
标题 :A production method and a new crystalline form of an intermediate of synthesis of ticagrelor
发明人：VOSLAR MICHAL; STRELEC IVO; DAMMER ONDREJ; VYSLOUZIL ROSTISLAV; STEHLĺČEK, Ivan; RIHA JAROSLAV; HES TOMAS; OBADALOVA IVA
权利人:ZENTIVA KS
摘要:The invention relates to preparation of ticagrelor of formula I and comprises a reaction of a compound of formula IV with a deprotection agent in a solvent to a compound of formula V, which is advantageously isolated by crystallization and subsequently used for the preparation of ticagrelor. The substituent R in formulae IV and V is CH 2 CH 2 OH, CH 2 COOH, or CH 2 COOR 1 ; R 1 is a branched or unbranched R1-C4 alkyl; and X is NH 2 , NO 2 f or NHCHO.

专利号:PL-211318-B1
优先权日:2000-06-02
标题:New intermediates for the synthesis of triazolopyrimidine compounds and the method of their preparation

专利号:PL-212128-B1
优先权日:2000-06-02
标 题:New intermediates for the synthesis of triazolopyrimidine compounds and the method of their preparation

专利号:CN-107089984-B
优先权日:2017-04-11
标题 :Synthesis method of ticagrelor