CAS: 150-25-4; 2-(Bis(2-Hydroxyethyl)Amino)Acetic Acid

相似化合物

139-13-9 93-62-9 150-39-0

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CAS号96-32-2 溴乙酸甲酯 | CAS号111-42-2 二乙醇胺 | CAS号79-11-8 氯乙酸 | CAS号98486-41-0 2-[bis(2-chloro... | CAS号64-69-7 碘乙酸 | CAS号3926-62-3 氯乙酸钠 | CAS号50-00-0 甲醛 | CAS号151-50-8 氰化钾 | CAS号53883-47-9 5-phenyl-4,6,11... | CAS号53883-49-1 5-methyl-4,6,11... | CAS号53883-57-1 5-ethenyl-4,6,1...

4-(2-Hydroxy-Ethyl)-Morpholin-2-One置于水体系中,化学反应生成N,N-二羟乙基甘氨酸
参考文献:Facile Hydrolysis And Formation Of Amide Bonds By N-Hydroxyethylation Of α-Amino Acids
标题:Facile Hydrolysis And Formation Of Amide Bonds By N-Hydroxyethylation Of α-Amino Acids
摘要:The C-Terminal Amides Of Alpha-Amino Acids Are Readily Hydrolyzed At 25 Degrees And Ph 7 When The N-Terminus Is N-Hydroxyethylated,With One Or Two Hydroxyethyl Groups. The Reaction Proceeds Via Cyclization To A Morpholinolactone (2) Which Is Rapidly Hydrolyzed By Water. In The Presence Of Equimolar Amounts Of Amines Or Amino Acid Derivatives,2 Reacts In H2O Without Condensing Agents To Form A New Peptide Bond. (C) 1997 Elsevier Science Ltd.
Doi:10.1016/s0040-4039(97)00330-4

专利信息

专利号:US-10501782-B1
优先权日:2014-09-05
标题:Cell-free synthesis of DNA by strand displacement
发明人：PORTER NEIL; ROTHWELL PAUL; EXTANCE JONATHAN
权利人:TOUCHLIGHT IP LTD
摘要:The present invention relates to an improved process for synthesis of DNA, RNA, proteins and like molecules, in particular cell-free enzymatic synthesis of DNA, preferably in large scale. The present invention relates to the synthesis of DNA using strand-displacement replication and the addition of nucleotides to the reaction mixture is controlled, thus controlling yield. The reaction mixture contains a starting amount of nucleotides, polymerase and DNA template, to which further nucleotides are supplied in a controlled manner.

专利号:US-12037623-B2
优先权日:2018-07-09
标 题 :Enzymatic synthesis of 4′-ethynyl nucleoside analogs
发明人：HUFFMAN MARK A; FRYSZKOWSKA ANNA; KOLEV JOSHUA N; DEVINE PAUL N; CAMPOS KEVIN R; TRUPPO MATTHEW; NAWRAT CHRISTOPHER C
权利人:MERCK SHARP & DOHME; MERCK SHARP & DOHME LLC
摘要:The present invention relates to an enzymatic synthesis of 4′-ethynyl-2′-deoxy nucleosides and analogs thereof, for example EFdA, that eliminates the use of protecting groups on the intermediates, improves the stereoselectivity of glycosylation and reduces the number of process steps needed to make said compounds. It also relates to the novel intermediates employed in the process.

专利号:US-8420848-B2
优先权日:2009-01-09
标题:Process for the synthesis of beta glycerol phosphate
发明人：KULKARNI YASHWANT
权利人:KULKARNI YASHWANT; SIGMA ALDRICH CO LLC
摘要:The present invention provides methods for the preparation of beta glycerol phosphate and its salts. In particular, the invention provides efficient methods for the synthesis of beta glycerol phosphate of high purity.

专利号:US-2025215464-A1
优先权日:2022-07-08
标题 :Engineered enzyme for preparing a hydroxylated indanone intermediate useful in the synthesis of belzutifan
发明人：CHEUNG-LEE WAI LING; DIROCCO DANIEL A; GIL AGNIESZKA; HIRAGA KAORI; KIM JUNGCHUL; KOLEV JOSHUA; KOSJEK BIRGIT; MALONEY KEVIN M; SALEHI MARZIJARANI NASTARAN; MCINTOSH JOHN; MCMULLEN JONATHAN P; MOORE JEFFREY C; MURPHY GRANT S; PAN WEILAN; VELASQUEZ VELEZ JUAN E; VERMA DEEPTAK; WINSTON MATTHEW S; XIAO LI; ZHANG VICTORIA
权利人:MERCK SHARP & DOHME LLC
摘要:The present disclosure provides enzymes derived from the fungi Fusarium oxysporum c8D (“FoPip4H enzymesâ€?) having improved properties as compared to a naturally occurring wild-type enzyme including the capability of hydroxylating certain substituted indanones to provide optically pure 3-hydroxyindanones. Also provided are polynucleotides encoding the FoPip4H enzymes, host cells capable of expressing the FoPip4H enzymes, and processes for using the FoPip4H enzymes to synthesize (R)-4-fluoro-3-hydroxy-7-(methylsulfonyl)-2, 3-dihydro-1H-inden-1-one, a useful intermediate in the synthesis of belzutifan.

专利号:EP-2017267-A1
优先权日:2007-07-16
标 题:Synthesis of statins
发明人：KOPITAR GREGOR; MRAK PETER; OSLAJ MATEJ
权利人:LEK PHARMACEUTICALS
摘要:The process for synthesis of statins is presented where the intermediate intermediate (4 R ,6 S )-6-(dialkoxymethyl)tetrahydro-2 H -pyran-2,4-diol which already possesses the desired stereochemistry corresponding to final statin is prepared by an aldolaze.

专利号:EP-2465936-A1
优先权日:2010-12-20
标题 :Enzymatic synthesis of statins and intermediates thereof
权利人:LEK PHARMACEUTICALS
摘要:The present invention discloses a process for preparing an active pharmaceutical ingredient (API) or intermediates thereof, notably particular step in the synthesis of an intermdiate useful for example in the preparation of statins, by using an enzyme capable of catalyzing oxidation or dehydrogenation. The invention further provides an expression system effectively translating said enzyme. In addition, the invention relates to a specific use of such enzyme for preparing API or intermediate thereof, and in particular for preparing statin or interemediate thereof.