CAS: 16965-06-3; N2-Boc-N6-(2,2,2-Trifluoroacetyl)-L-Lysine

上下游产品

S-ethyl trifluoroacetate B°C-Lys-OH ethyl trifluoroacetate, B°C-Lys(Fm°C)-OH N-alpha-B°C-N-epsilon-TFA-lysine succinimidyl ester

Nalpha-Boc-Nε-Fmoc-L-赖氨酸置于哌啶,N,N-二甲基甲酰胺体系中,用 甲醇 用作溶剂,化学反应 2.05H,反应生成丁氧羰基-羟基化赖氨酸(Tfa)
参考文献:Reversible Protection Of Lysine To Facilitate The Purification Of Protected Peptide Segments
标题:Reversible Protection Of Lysine To Facilitate The Purification Of Protected Peptide Segments
摘要:The Polarity Of Temporarily Free Lysine Side Chains Can Be Exploited To Aid In The Purification Of Protected Peptides. The Amine Groups Can Easily Be Reprotected After The Purification Step. Impurities In Commercial Tfe1 Can Cause Trifluoroacetylation Of Free Primary Amines.
Doi:10.1016/s0040-4039(00)74141-4

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.