CAS: 313368-91-1; Lumateperone

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MSDS等安全信息

    合成工艺路线路线简述

    • 合成目标产物 Lumateperone 主要起始原料 (6Br,10As)-3-Methyl-2,3,6B,7,8,9,10,10A-Octahydro-1H-Pyrido[3',4':4,5]Pyrrolo[1,2,3-De]Quinoxaline And 4'-Fluoro-4-Iodobutyrophenone
    • (文献来源)合成步骤主要原料 (6Br,10As)-3-Methyl-2,3,6B,7,8,9,10,10A-Octahydro-1H-Pyrido[3',4':4,5]Pyrrolo[1,2,3-De]Quinoxaline 和 4'-Fluoro-4-Iodobutyrophenone

    海关参考信息

    专利信息


    专利号:WO-2025154001-A1
    优先权日:2024-01-18
    标 题:An improved process for the preparation of lumateperone and salt thereof
    发明人:KANWAL PUSHKARNATH PANDITA; SURAPARAJU RAGHU RAM; C RAVEENDRA REDDY
    权利人:OPTIMUS DRUGS PVT LTD
    摘要:The present invention provides an improved process for the preparation of Lumateperone (I) and salts thereof with high yield and enhanced purity Furthermore, the present invention relates to the preparation of the compound of formula (VII), which is utilized in the synthesis of Lumateperone (I).

    专利号:ES-2776889-T3
    优先权日:2007-03-12
    标题 :Synthesis of gamma-carbolines fused to substituted heterocycle

    专利号:US-2023271983-A1
    优先权日:2020-07-29
    标题 :Functionalized isonitriles and products, preparation and uses thereof
    发明人:SOTELO PÉREZ EDDY; AZUAJE GUERRERO JHONNY ALBERTO; MAJELLARO MARIA
    权利人:UNIV SANTIAGO COMPOSTELA
    摘要:The present invention relates to functionalized isonitrile compounds, formed by means of multicomponent environmentally friendly reactions, suitable for coupling to functional molecules such as biomolecules, APIs, chromophore and fluorophore molecules. The invention also relates to conjugates between said isonitrile compounds and functional molecules, which are useful in the synthesis of pharmaceutic drugs or tools, fluorescent molecules and labels, polymeric smart materials. The invention furthermore provides a kit for the in-vitro preparation of the functionalized isontrile compounds and conjugates. The invention also contemplates the medical use of said compounds and conjugates.

    专利号:US-11453670-B2
    优先权日:2018-06-11
    标 题:Substituted heterocycle fused gamma-carbolines synthesis
    发明人:LI PENG; ZHANG QIANG
    权利人:INTRA CELLULAR THERAPIES INC
    摘要:The present invention provides improved methods for the preparation of substituted heterocycle fused gamma-carbolines, intermediates useful in producing them and methods for producing such intermediates and such heterocycle fused gamma-carbolines.

    专利号:JP-6231151-B2
    优先权日:2007-03-12
    标题:Synthesis of substituted heterocyclic fused gamma-carbolines

    专利号:JP-2010521464-A
    优先权日:2007-03-12
    标 题:Synthesis of substituted heterocyclic fused gamma-carbolines
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    主要参考文献


    1: Kumar B, Kuhad A, Kuhad A. Lumateperone: a new treatment approach for neuropsychiatric disorders. Drugs Today (Barc). 2018 Dec;54(12):713-719. doi: 10.1358/dot.2018.54.12.2899443.

    合成参考文献


    摘要:Kleemann A., Kutscher B., Reichert D., Bossart M., Pharmaceutical Substances, Thieme [Online], Stuttgart, (2026).
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