CAS: 32213-95-9; H-Asp(Ome)-Ome Hcl

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CAS号67-56-1 甲醇 | CAS号56-84-8 L-天门冬氨酸 | CAS号75-77-4 三甲基氯硅烷 | CAS号1783-96-6 D-天门冬氨酸 | CAS号75-36-5 乙酰氯 | CAS号2177-62-0 (S)-2-氨基-4-甲氧基-... | CAS号617-55-0 L-苹果酸二甲酯 | CAS号554-68-7 三乙胺盐酸盐 | CAS号2387-23-7 N,N’-二环己基脲 | CAS号167082-77-1 B°C-Asp-[Asp-(O... | CAS号145038-53-5 Fm°C-L-天冬氨酸4-甲酯 | CAS号16856-13-6 L-天冬氨酸-β-甲酯盐酸盐

L-天门冬氨酸置于氯化亚砜体系中,用 甲醇 作为反应溶剂,以98 %的收率获得产物l-天冬氨酸二甲酯盐酸盐
参考文献:酰胺功能化 L-天冬氨酸两亲性聚酯纳米组件的熔融缩聚策略和癌细胞中的酶响应药物递送
标题:酰胺功能化 L-天冬氨酸两亲性聚酯纳米组件的熔融缩聚策略和癌细胞中的酶响应药物递送
摘要:脂肪族聚酯本质上是可酶促生物降解的,癌症研究中对安全智能的下一代生物材料(包括药物递送纳米载体)的需求不断增长.使用基于生物资源的可生物降解聚酯是满足这一要求的优雅策略之一;在这里,我们报告了一个基于l-氨基酸的酰胺功能化聚酯平台,并探索了它们的溶酶体酶促生物降解方面,以在癌细胞中施用抗癌药物.升-选择了天冬氨酸,并定制了具有芳香族,脂肪族和生物源侧链单元的不同酰胺侧链功能化二酯单体.在无溶剂熔融缩聚法下;这些单体经过聚合反应反应生成具有可调热性能的高分子量聚酯.聚乙二醇化l-天冬氨酸单体被设计用来制造热敏性两亲聚酯.这种两亲性聚酯在水性介质中自组装成 140 +/-10 Nm 大小的球形纳米颗粒,其临界溶解温度较低,为 40-42 oc.聚酯纳米组件对抗癌药物多柔比星 (Dox),抗炎药物姜黄素,生物标志物如玫瑰红 (Rb) 和 8-羟基芘-1,3,6-三磺酸三钠盐具有出色的包封能力.发现两亲性聚酯
DOI:10.1021/acs.Biomac.3C00127

专利信息

专利号:US-6077962-A
优先权日:1998-12-24
标题 :N-3, 3-dimethylbutyl-L-aspartic acid and esters thereof, the process of preparing the same, and the process for preparing N-(N-(3,3-dimethylbutyl) -α L-aspartyl)-L- phenylalanine 1-methyl ester therefrom
发明人：PRAKASH INDRA; CHAPEAU MARIE-CHRISTINE D
权利人:NUTRASWEET CO
摘要:This invention relates to the chemical synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester using peptide coupling methods. The coupling reaction is conducted by condensation of an activated derivative of novel N-neohexyl-L-aspartic acid with L-phenylalanine or L-phenylalanine methyl ester or by enzymatic coupling of N-neohexyl-L-aspartic acid with L-phenylalanine or L-phenylalanine methyl ester. This invention also relates to novel N-(3,3-dimethylbutyl)-L-aspartic acid, derivatives thereof and the preparation thereof. The activated derivative of N-neohexyl-L-aspartic acid may be an anhydride, mixed anhydride, active ester or an intermediate activated derivative thereof.

专利号:US-3891692-A
优先权日:1972-05-03
标题:N-(cyclopropylalkoxycarbonyl)amino acids
发明人：VEBER DANIEL F; BRADY STEPHEN F
权利人:MERCK & CO INC
摘要:Novel N-protected- Alpha -amino acid compounds are disclosed in which the amino functionality is protected by a cyclopropylmethoxycarbonyl or 1-cyclopropyl-ethoxycarbonyl. Processes for the synthesis of amino acids containing these protecting groups and the use of these novel amino acid compounds in the preparation of peptides are also disclosed.

专利号:US-3948971-A
优先权日:1972-05-03
标题 :N-protected-α-amino acid compounds
发明人：VEBER DANIEL F; BRADY STEPHEN F
权利人:MERCK & CO INC
摘要:Novel N-protected-α-amino acid compounds are disclosed in which the amino functionality is protected by a 1-methylcyclobutyloxycarbonyl or 1-methylcyclohexyloxycarbonyl. Processes for the synthesis of amino acids containing these protecting groups and the use of these novel amino acid compounds in the preparation of peptides are also disclosed.

专利号:WO-9221675-A1
优先权日:1991-06-03
标题:Synthesis of optically active lactones from l-aspartic acid and intermediates thereof

专利号:EP-0643710-A1
优先权日:1991-06-03
标 题 :Synthesis of optically active lactones from l-aspartic acid and intermediates thereof

专利号:US-5322942-A
优先权日:1991-06-03
标题 :Synthesis of optically active lactones from L-aspartic acid and intermediates thereof
发明人：RAPOPORT HENRY; DENER JEFFREY M; ZHANG LIN-HAU
权利人:UNIV CALIFORNIA
摘要:Optically active lactones are described, such as an intermediate lactone having the formula ##STR1## where R and R 2 are each independently alkyl with 1 to 6 carbon atoms, cycloalkyl with 6 to 10 carbon atoms, aryl with 6 to 10 carbon atoms, or arylalkyl with 7 to 19 carbon atoms, R 4 is H or C 1-6 alkyl, and Ar is a homo- or heteroaromatic ring with 5 or 6 ring atoms being optionally substituted by C 1-6 alkyl or alkoxy groups, halogen atoms, cyano or nitro groups. Such optically active, intermediate lactones are prepared from L-aspartic acid, and can be readily converted to (+)-pilocarpine and its analogues by hydrolysis, reduction, and hydrogenation, such as to an optically active lactone having the formula ##STR2## which is (+)-pilocarpine when R is ethyl, R 4 is H, and Ar is 1-methylimidazol-5-yl.