2-硝基-Alpha,Alpha,Alpha-三氟甲苯置于钯体系中,化学反应生成 2-碘三氟甲基苯 参考文献:Jones,Journal Of The American Chemical Society,1947,Vol. 69,P. 2352 标题:Jones,Journal Of The American Chemical Society,1947,Vol. 69,P. 2352
专利号:WO-0009116-A1 优先权日:1998-08-14 标 题:Grp receptor ligands 发明人:XIANG JIA-NING; KARPINSKI JOSEPH M; CHRISTENSEN SIEGFRIED B IV 权利人:SMITHKLINE BEECHAM CORP; XIANG JIA NING; KARPINSKI JOSEPH M; CHRISTENSEN SIEGFRIED B IV 摘要:Novel GRP receptor antagonists are provided. Methods of using the present compounds to antagonize GRP receptors are also provided. The present invention further involves the synthesis of the present compounds.
专利号:CN-1829673-A 优先权日:2001-12-14 标 题 :Synthesis of alpha, beta-trifluorostyrene by in situ formation of trifluorovinyl metal halide
专利号:US-7615634-B2 优先权日:2003-02-10 标题:4-aminopyrimidine-5-one derivatives 发明人:BARTKOVITZ DAVID JOSEPH; CHU XIN-JIE; DING QINGJIE; JIANG NAN; LOVEY ALLEN JOHN; MOLITERNI JOHN ANTHONY; MULLIN JR JOHN GUILFOYLE; VU BINH THANH; WOVKULICH PETER MICHAEL 权利人:HOFFMANN LA ROCHE 摘要:Novel intermediate compounds are disclosed. These compounds are useful in the synthesis of 4-aminopyrimidine-5-one derivatives that inhibit cyclin-dependent kinases, in particular cyclin-dependent kinase 4 (Cdk4). The 4-aminopyrimidine-5-one derivatives and their pharmaceutically acceptable salts have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors.
专利号:CN-113087691-B 优先权日:2021-03-26 标题:A method for the synthesis of chiral aryl tertiary alcohols and benzopyrans based on a kinetic resolution strategy
专利号:US-5420351-A 优先权日:1993-11-25 标题 :Aromatic diamine compounds 发明人:SUZUKI OSAMU; YOKOMIZO HIROHIKO; ARAI TAKESHI; NAKAJIMA NAMIKO 权利人:NISSHIN SPINNING 摘要:An aromatic diamine compound represented by formula (1): ##STR1## wherein R 1 and R 2 , which may be the same or different, are each a hydrogen atom or a lower alkyl group; and an aromatic diamine compound useful as an intermediate for the synthesis of the above compound (1), represented by formula (2): ##STR2## The compound (1) alleviates the problems of the prior art, and is unlikely to cause crystallization by heat and has a melting point and a glass transition temperature both higher than those of conventional compounds.
专利号:WO-0009115-A1 优先权日:1998-08-14 标 题 :Grp receptor ligands 发明人:XIANG JIA-NING; OSIFO IRENNEGBE KELLY; KARPINSKI JOSEPH M; CHRISTENSEN SIEGFRIED B IV 权利人:SMITHKLINE BEECHAM CORP; XIANG JIA NING; OSIFO IRENNEGBE KELLY; KARPINSKI JOSEPH M; CHRISTENSEN SIEGFRIED B IV 摘要:Novel GRP receptor antagonists are provided. Methods of using the present compounds to antagonize GRP receptors are also provided. The present invention further involves the synthesis of the present compounds.