CAS: 545-47-1; Lupeol

该化合物是主要在水果,蔬菜和药用药草等各种植物中发现的三元素化合物,其特征是五环结构,有助于其各种生物活动;卢皮醇表现出抗炎,抗氧化剂和抗癌特性,使其对药理研究感兴趣;该化合物通常是白到苍白的黄色晶状固体,在水中溶解度较低,但在乙醇和氯仿等有机溶剂中可溶解;其分子式为C30H50O,分子重量相对较高;卢皮醇已经研究其潜在的治疗作用,包括抑制肿瘤生长和调节癌症演变中的各种信号途径的能力;此外,它可能具有抗微生物特性,进一步提高其在天然产品化学和医药潜在应用中的重要性;

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号1617-68-1 羽扇豆醇 3-乙酸酯 | CAS号1617-70-5 羽扇烯酮 | CAS号6610-55-5 算盘子酮 | CAS号1375064-00-8 lup-20(29)-en-3... | CAS号473-98-3 白桦脂醇; 桦木醇 | CAS号27570-20-3 Betulin-3-acetate | CAS号27570-21-4 3-O-acetylbetul... | CAS号20065-99-0 29-羟基羽扇豆醇 | CAS号638-95-9 α-香树脂醇 | CAS号559-70-6 beta-香树精 | CAS号464-98-2 Pseudotaraxasterol | CAS号1059-14-9 蒲公英甾醇 | CAS号3186-72-9 Lupan-3-one | CAS号1617-70-5 羽扇烯酮

合成工艺路线路线简述

  • 合成目标产物 Lupeol 主要起始原料 3-Acetyl Betulinaldehyde
  • (文献来源)合成步骤主要原料 3-Acetyl Betulinaldehyde
羽扇烯酮置于氢氧化钾体系中,用 二乙二醇 作为反应溶剂,以50%的收率获得产物羽扇豆醇
参考文献:用氢氧化钾-二甘醇将酮还原为差向异构醇
标题:用氢氧化钾-二甘醇将酮还原为差向异构醇
摘要:三萜类酮在二甘醇中与氢氧化钾煮沸时已还原为差向异构醇.K,β-不饱和酮提供饱和差向异构醇.
DOI:10.1016/s0040-4020(01)96647-5

海关参考信息

专利信息


专利号:US-2023157936-A1
优先权日:2021-11-24
标 题 :Anti-aging skin peel composition and method of application
发明人:ZAHR ALISAR; NGUYEN THU Q; KOCH JOHN; KELLY TATIANA
权利人:JAMRM LLC
摘要:A skincare composition and a method for removing layers of skin in a cosmetic procedure. The skincare composition comprises active ingredients mixed into a cosmetically acceptable carrier. The active ingredients include an effective amount of one or more keratolytic agents for inducing a desired degree of keratolysis in the skin, an effective amount of one or more free radical neutralizing agents for negating cellular damage from reactive chemical species, and an effective amount of one or more agents increasing synthesis of dermal components. The one or more free radical neutralizing agents and the one or more agents increasing synthesis of dermal components are acids in their un-neutralized, natural acid form, and a total amount of the active ingredients is less than 50 w/w% of the skincare composition, and a pH of the skincare composition is between 1.5-3.5.

专利号:US-2009131714-A1
优先权日:2005-06-08
标题:Synthesis of betulonic and betulinic aldehydes
发明人:KRASUTSKY PAVEL A; MUNSHI KALYAN
权利人:KRASUTSKY PAVEL A; MUNSHI KALYAN
摘要:The present invention provides for methods of selectively converting betulin to betulonic aldehyde. The present invention also provides for methods of selectively converting 3-substituted triterpen-28-ols to the corresponding 3-substituted triterpen-28-carboxaldehydes. Additionally, the present invention provides for methods of preparing betulonic aldehyde, betulonic acid, betulinic acid, and corresponding 3-substituted triterpenes.

专利号:US-2022162188-A1
优先权日:2019-01-15
标 题:Isoprenoids and methods of making thereof
发明人:WILLIAMS GAVIN; LUND SEAN; HALL RACHAEL
权利人:UNIV NORTH CAROLINA STATE
摘要:Disclosed are methods for preparing isoprenoid subunits, as well as methods of employing these isoprenoid subunits for the synthesis of isoprenoids. Also provided are isoprenoids prepared using the methods described herein.

专利号:US-8747815-B2
优先权日:2003-07-18
标题:Use of a cosmetic of pharmaceutical composition, comprising a lupeol-rich extract as an active ingredient for stimulating the synthesis of heat shock proteins
发明人:MSIKA PHILIPPE; PICCIRILLI ANTOINE; PICCARDI NATHALIE
权利人:MSIKA PHILIPPE; PICCIRILLI ANTOINE; PICCARDI NATHALIE; EXPANSCIENCE LAB
摘要:The present invention relates to the use of a lupeol-rich extract for the production of a cosmetic or pharmaceutical composition for treating and/or preventing a connective tissue degeneration. Said invention also relates to the use of a lupeol-rich extract for the production of a pharmaceutical composition for preventing and/or treating non-inflammatory articular pathologies, periodontal diseases and stretch marks. The invention also relates to the use of a lupeol-rich extract for the production of a cosmetic composition as a cicatrizing agent, a restructuring agent and an anti-sagging agent for skin and/or mucosae.

专利号:US-12187735-B2
优先权日:2018-09-17
标 题:Matter of composition, synthesis, formulation and application of FL118 platform positions 7 and 9-derived analogues for treatment of human disease
发明人:LING XIANG; LI QINGYONG; LI FENGZHI
权利人:CANGET BIOTEKPHARMA LLC
摘要:Described herein, are the chemical synthesis, matter of compositions, formulation, function, methods and uses of the FL118 platform Positions 7 and/or 9-derived analogues for treating cancer or other human diseases. Compounds derived from chemical modifications of the FL118 platform are employed alone or in combination with other anti-cancer agents to preclude, eliminate or reverse cancer phenotypes. This invention intends to realize unique personalized cancer treatment (personalized precision medicine) through application of a series of structural relevant individual FL118 platform-derived analogues, which target multiple cellular human disease-relevant proteins and their signaling pathways.

专利号:US-2025092058-A1
优先权日:2018-09-17
标 题 :Matter of composition, synthesis, formulation and application of fl 118 platform positions 7 and 9-derived analogues for treatment of human disease
发明人:LING XIANG; LI QINGYONG; LI FENGZHI
权利人:CANGET BIOTEKPHARMA LLC
摘要:Described herein, are the chemical synthesis, compounds, methods and uses of the fluoroaryl-substituted derivatives at the FL118 position 7, which target multiple cellular human disease-relevant proteins and their signaling pathways.
陕西帕尼尔生物科技有限公司
⚠️ 未注册 · 未认证企业
⚠️ 该商家尚未完成注册及企业认证,请用户仔细辨别,谨慎交易。
数据来源于公开网络搜索,平台未作核实,请自行辨别。
🏢敬请 企业认领
🏬开设公司展台
📢获取免费会员权益
🎖️点亮专属注册企业标签
📇展现公司完整信息 样本查看立即注册认领 →
网址: http://www.pioneerbiotech.com
企业联系电话:029-84385017-8001👤
📞陕西帕尼尔生物科技有限公司 ⚠️参考联系方式
联系人:高经理;肖经理
电话:029-84385017-8001
手机:高经理13259417953
传真:QQ:1477918929
邮箱:sales5@pioneebiotech.com
通信地址: 陕西省西安市未央区凤城十路保利中达广场
邮编: 710000
🆔 联系时候可告知是从"百琢研"平台获取的信息.
⚠️ 声明: 该企业未认证、未认领,请自行辨别信息的真实性和可靠性。咨询或交易时请注意风险评估与信息核实,百琢研不参与任何交易。企业认领注册入口→

地址:陕西省西安市未央区凤城十路保利中达广场
⚠️ 未注册 · 未认证企业
注册入口 备注: 📌 数据来源说明:本展台内容基于各搜索引擎等公开数据整理,仅作展示用途。请用户自行辨别
✉️ 若企业需抹除展台内容或有异议, 请通过页面底部联系方式告知我们,我们会尽快处理。
第 1 / 1 页
现货

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献


1: Siveen KS, Nguyen AH, Lee JH, Li F, Singh SS, Kumar AP, Low G, Jha S, Tergaonkar V, Ahn KS, Sethi G. Negative regulation of signal transducer and activator of transcription-3 signalling cascade by lupeol inhibits growth and induces apoptosis in hepatocellular carcinoma cells. Br J Cancer. 2014 Sep 23;111(7):1327-37. doi: 10.1038/bjc.2014.422. Epub 2014 Aug 7.
2: Bhandari P, Patel NK, Bhutani KK. Synthesis of new heterocyclic lupeol derivatives as nitric oxide and pro-inflammatory cytokine inhibitors. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3596-9. doi: 10.1016/j.bmcl.2014.05.032. Epub 2014 May 22. doi: 10.3109/09553002.2015.966209. Epub 2015 Jan 27. doi: 10.1002/ptr.5423. Epub 2015 Jul 16. doi: 10.1021/np500296b. Epub 2014 Oct 17. doi: 10.1038/jid.2015.29. Epub 2015 Feb 3. doi: 10.1039/c4mb00635f. doi: 10.1016/j.bmcl.2014.04.059. Epub 2014 Apr 24. doi: 10.1016/j.fitote.2014.08.005. Epub 2014 Aug 10. doi: 10.1016/j.lfs.2010.11.020. Epub 2010 Nov 29. Review. doi: 10.1016/j.lfs.2012.01.012. Epub 2012 Feb 2. doi: 10.1016/j.bbrc.2014.04.090. Epub 2014 Apr 26. Chinese. doi: 10.4046/trd.2015.78.3.210. Epub 2015 Jun 30.
16: de Lima FO, Alves V, Barbosa Filho JM, Almeida JR, Rodrigues LC, Soares MB, Villarreal CF. Antinociceptive effect of lupeol: evidence for a role of cytokines inhibition. Phytother Res. 2013 Oct;27(10):1557-63. doi: 10.1002/ptr.4902. Epub 2012 Dec 3. doi: 10.1007/s10787-011-0095-3. Epub 2011 Oct 16. doi: 10.1007/s00210-014-1071-4. Epub 2014 Nov 25. Epub 2013 May 28.

合成参考文献


参考文献:10.1248/bpb.28.158
摘要:Akihisa T, Franzblau SG, Ukiya M, Okuda H, Zhang F, Yasukawa K, Suzuki T, Kimura Y. Antitubercular Activity of Triterpenoids from Asteraceae Flowers. Biological & Pharmaceutical Bulletin. 2005;28(1):158–60. doi: 10.1248/bpb.28.158.
参考文献:10.1248/cpb.54.535
摘要:Suksamrarn S, Panseeta P, Kunchanawatta S, Distaporn T, Ruktasing S, Suksamrarn A. Ceanothane- and lupane-type triterpenes with antiplasmodial and antimycobacterial activities from Ziziphus cambodiana. Chem Pharm Bull (Tokyo). 2006 Apr;54(4):535–7. doi: 10.1248/cpb.54.535.
📝 需求与反馈
尽可能描述清楚需求与问题信息
×

通知