CAS: 71643-66-8; 4-Chloro-2-Iodophenol

该化合物是有机化合物,其特点是苯球环上存在氯和碘替代物,其特征是附于苯环的氢氧基(-OH),有助于将其分类为苯酚.氯原子位于相对于氢氧基组的副位置(4个位置),而碘原子位于正方位(2个位置),这种替代模式影响化合物的再活性和物理特性,如溶性点和沸点.4-Croloo-2-iodophenol在室温中通常是固态的,在有机溶剂中可能表现出中等溶性.它常常用于各种化学合成化学品,并可作为生产药品或农用化学品的一种中间体.此外,卤素的存在可以带来独特的生物活动,从而引起对医药化学的兴趣.与许多卤化化合物一样,在处理时,由于潜在的毒性和环境关切,应当采取安全防范措施.

结构式图片

相似化合物

15459-50-4 28177-52-8 2040-83-7

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

2-Iodophenol 4-chloro-phenol 2-hydroxy-5-chloro-aniline 4-chloro-2-iodo-1-methoxybenzene 2,4-dichloro-6-iodophenol 4-chloro-2,6-diiodo-phenol 4-chloro-2-iodophenyl acetate

合成工艺路线路线简述

    4-氯-2-碘苯甲醚,在 三溴化硼,甲醇体系中,化学反应 3.5H,以88%的收率获得产物4-氯-2-碘苯酚
    参考文献:Fused Tricyclic Compounds As Inhibitors Of 17Beta-Hydroxysteroid Dehydrogenase 3
    标题:Fused Tricyclic Compounds As Inhibitors Of 17Beta-Hydroxysteroid Dehydrogenase 3
    摘要:融合三环化合物,使用这种化合物治疗激素敏感性疾病如前列腺癌的方法,以及含有这种化合物的药物组合物.

    海关参考信息

    专利信息


    专利号:EP-1491540-B1
    优先权日:2001-03-30
    标题 :Intermediates useful for the synthesis of pyridazinone aldose reductase inhibitors

    专利号:US-7473786-B1
    优先权日:2003-12-05
    标题:Methods and systems for preparing fused heterocyclic compounds using copper(I) catalysts
    发明人:VENKATARAMAN DHANDAPANI; BATES CRAIG G; SAEJUENG PRANORM
    权利人:UNIV MASSACHUSETTS
    摘要:A copper(I)-catalyzed procedure for the synthesis of benzo[b]heterocycles. This protocol can be used to synthesize a variety of 2-arylbenzo[b]furans and indoles in good to excellent yields. This method can tolerate a variety of functional groups, does not require the use of expensive additives and is palladium-free.

    专利号:ES-2274369-T3
    优先权日:2001-03-30
    标 题:USEFUL INTERMEDIATES FOR SYNTHESIS OF PIRIDAZINONAS INHIBIDORAS OF ALDOSA REDUCTASA.

    专利号:US-9067934-B2
    优先权日:2011-03-31
    标题 :Bicyclic pyridinones
    发明人:PETTERSSON MARTIN YOUNGJIN; JOHNSON DOUGLAS SCOTT; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; AM ENDE CHRISTOPHER WILLIAM; FISH BENJAMIN ADAM; GREEN MICHAEL ERIC; MULLINS PATRICK BRADLEY; STIFF CORY MICHAEL; TRAN TUAN PHONG; NAVARATNAM THAYALAN
    权利人:PFIZER
    摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined herein. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

    专利号:CN-115197182-A
    优先权日:2022-07-01
    标 题:A kind of synthesis technique of halogenated dibenzofuran derivative

    专利号:US-11286268-B1
    优先权日:2019-07-02
    标题:EIF4E-inhibiting compounds and methods
    发明人:SPERRY SAMUEL; XIANG ALAN X; ERNST JUSTIN T; REICH SIEGFRIED H; SPRENGELER PAUL A; SHAGHAFI MIKE; MICHELS THEO; NILEWSKI CHRISTIAN; TRAN CHINH VIET; PACKARD Garrick Kenneth; GRUBBS ALAN; URKALAN KAVERI; MUKAIYAMA TAKASUKE
    权利人:EFFECTOR THERAPEUTICS INC
    摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n n n n n n n n n n For Formula I compounds X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , Q, L 1 , L 2 , Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and rings A, B and C are as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4e and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.
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    主要参考文献

    参考标题:Construction Of 2-Substituted-3-Functionalized Benzofurans Via Intramolecular Heck Coupling: Application To Enantioselective Total Synthesis Of Daphnodorin B
    作者:Hu Yuan,Kai-Jian Bi,Bo Li,Rong-Cai Yue,Ji Ye,Yun-Heng Shen,Lei Shan,Hui-Zi Jin,Qing-Yan Sun,Wei-Dong Zhang |发布日期:2013.9.20
    摘要:A Novel Approach Was Developed For The Synthesis Of 2-Substituted-3-Functionalized Benzofurans, Using An Intramolecular Heck Reaction Which Was Further Applied In The First Enantioselective Total Synthesis Of Daphnodorin B.

    合成参考文献


    摘要:Kwiecień, H., Science of Synthesis Knowledge Updates, (2014) 4, 68.
    摘要:Kwiecień, H., Science of Synthesis Knowledge Updates, (2014) 4, 63.
    摘要:Dong, X.; Liu , H., Science of Synthesis Knowledge Updates, (2019) 3, .
    摘要:Cheng, B.; Wang, T., Science of Synthesis Knowledge Updates, (2020) 3, 191.
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