CAS: 768-66-1; 2,2,6,6-Tetramethylpiperidine

相似化合物

766-17-6 2138145-63-6 1254339-11-1

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CAS号826-36-8 四甲基哌啶酮 | CAS号2564-83-2 2,2,6,6-四甲基哌啶-1-氧自由基 | CAS号100-46-9 苄胺 | CAS号79-55-0 五甲基哌啶 | CAS号84-65-1 蒽醌 | CAS号108-88-3 甲苯 | CAS号7031-93-8 1-羟基-2,2,6,6-四甲基哌啶 | CAS号104172-64-7 chloro(diphenyl... | CAS号360576-04-1 6-溴-2,3-二氟苯甲醛 | CAS号312736-49-5 3,5-二氯吡嗪-2-甲酸 | CAS号4957-14-6 二对甲苯基甲烷 | CAS号38227-87-1 四甲基哌啶锂 | CAS号201008-68-6 (4-methoxypheny... | CAS号99432-15-2 2,2,6,6-tetrame... | CAS号829-85-6 二苯基膦 | CAS号815-66-7 3-Hexanone,4-hy... | CAS号73333-58-1 2,2,2-trifluoro... | CAS号79-55-0 五甲基哌啶

1-羟基-2,2,6,6-四甲基哌啶置于正丁基锂体系中,用 二氯甲烷 作为反应溶剂,化学反应 40.33H,反应生成 2,2,6,6-四甲基哌啶
参考文献:热解的ñ-Tetramethylpiperidinyl三苯基:一个tempo酯的均裂碎片†
标题:热解的ñ-Tetramethylpiperidinyl三苯基:一个tempo酯的均裂碎片†
摘要:N-四甲基哌啶基三苯基乙酸酯(7,Ph 3 Cco 2 T,T = 2,2,6,6-四甲基哌啶基)在146oc的苯中热分解导致形成三苯基甲烷(ph 3 Ch,80%),四甲基哌啶(Th(91%)和四苯甲烷(ph 4 C,9%).在132.8oc和150.0oc下分解的一级速率常数分别为2.20x10-6和2.88x10-5 S-1.在苯-D 6溶剂中,三苯甲烷以ph 3 Cd的形式反应生成,其含量为20%(由1确定).1 H NMR和质谱.结果被解释为表示博士3 Cco 2通过与形成的ph协调一致两键断裂ť经历热解3 ç ⋅,四甲基自由基和co 2.ph的形成4下用加入ph的发生3 ç ⋅苯,随后从所得到的加合物的氢原子的抽象.使用dft方法在b3Lyp / 6-311 ++ G **水平计算被用来阐明hco的键裂变2 T(2),并且表明裂解以hco 2 ⋅和t ⋅由7.8千卡摩尔青睐-1相对于裂解hc(•)o和to
DOI:10.1002/poc.655

专利信息

专利号:US-4910310-A
优先权日:1988-10-03
标 题:Synthesis of N-substituted 1,5-dideoxy-1,5-imino-L-fucitol derivatives
发明人：CAMPBELL ARTHUR L; BEHLING JAMES R; BABIAK KEVIN A; NG JOHN S; MUELLER RICHARD A; FLEET GEORGE W J
权利人:SEARLE & CO
摘要:Novel intermediates and method for the chemical synthesis of N-substituted 1,5-dideoxy-1,5-imino-L-fucitol derivatives are provided. A preferred intermediate is 1,5-dideoxy-1,5-imino-3, 4-O-isopropylidene-L-fucitol which is used to prepare the HIV inhibitor 1,5-dideoxy-1,5-imino-[N-ω-methyl caproate]-L-fucitol. These compounds are prepared in a short synthesis from the known compound 2,3-O-isopropylidene-D-lyxono-1,4-lactone or in a multi-step synthesis from D-galactose.

专利号:WO-2012047907-A9
优先权日:2010-10-04
标题 :Synthesis of c5-substituted tetracyclines, uses thereof, and intermediates thereto
发明人：MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN
权利人:HARVARD COLLEGE; MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN
摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for a wide variety of substituents at position 5 of the tetracycline ring system.

专利号:US-9688644-B2
优先权日:2009-04-30
标 题 :Synthesis of Tetracyclines and intermediates thereto
发明人：MYERS ANDREW G; KUMMER DAVID A; LI DERUN; HECKER EVAN; DION AMELIE; WRIGHT PETER M
权利人:HARVARD COLLEGE
摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for substituents at positions 4a, 5, 5a, and 12a of the tetracycline ring system.

专利号:US-11059914-B2
优先权日:2016-12-21
标题:Method for the continuous synthesis of a diene elastomer with lithium amide initiator
发明人：DIRE CHARLOTTE; DESSENDIER MARIE-HÉLÈNE
权利人:MICHELIN & CIE
摘要:A process for the continuous synthesis of a diene elastomer is provided. The synthesis is conducted by means of n reactors r1 to rn, considered to be continuous stirred-tank reactors, which are equipped with an internal stirring system. The reactors are arranged in series, n varying from 2 to 15, preferably from 2 to 9. The reactor r1 is fed by an input solution comprising a solvent, one or more monomer(s), an anionic polymerization initiator chosen from lithium amides and a polar agent. The conversion by weight C1 in the first reactor is less than 70%, and the total conversion by weight Cn at the outlet of the reactor rn is greater than or equal to 70%.

专利号:US-2024067694-A1
优先权日:2021-01-04
标 题:Synthesis of teduglutide
发明人：GANGA RAMU VASANTHAKUMAR; PATIL NITIN; SUVARNA DEEPA SHANKAR
权利人:BIOCON LTD
摘要:The present invention provides for novel synthetic approach of solid phase synthesis of peptides with C-terminal Aspartic acid by anchoring the side chain carboxylic group of aspartic acid to the solid support to avoid the formation of various impurities and thus resulting in higher yield and ease the purification process. The present invention further provides the usage of free amino acids and reducing agents as antioxidants in the cleavage cocktail to negate the formation of oxidative impurities formed during the global cleavage and isolation of the peptide from solid support.

专利号:US-2024400517-A1
优先权日:2022-02-08
标 题 :Chiral bimetallic cooperative catalysis system and use thereof in asymmetric synthesis of bedaquiline
发明人：ZHANG WANBIN; GAO FENG; LI JING; AHMAD TANVEER; ZHANG ZHENFENG; YUAN QIANJIA
权利人:UNIV SHANGHAI JIAOTONG
摘要:A chiral bimetallic cooperative catalysis system and use thereof in asymmetric synthesis of bedaquiline are provided. Specifically, the chiral bimetallic cooperative catalysis system is formed by a metallic lithium, sodium or potassium salt and another metal salt under the action of a suitable ligand and an additive. By means of the chiral bimetallic cooperative catalysis system, an addition reaction of 6-bromo-3-benzyl-2-methoxyquinoline (I) and 3-dimethylamino-1-naphthyl-1-propanone (II) is promoted, the selectivity is regulated, and a target product, (1R,2S)-bedaquiline, with high yield and high selectivity is obtained for the first time.