CAS: 139042-59-4; 5-Acetyl-2-Bromopyridine

相似化合物

139042-62-9 139163-63-6 136592-20-6

上下游产品

CAS号624-28-2 2,5-二溴吡啶 | CAS号127-19-5 N,N-二甲基乙酰胺(DMAC) | CAS号136592-20-6 2-溴-1-(6-溴吡啶-3-基)乙酮 | CAS号35022-79-8 1-(6-Phenylpyri...

2,5-二溴吡啶,N,N-二甲基乙酰胺置于正丁基锂体系中,用 乙醚,正己烷 用作溶剂,化学反应 1.5H,以51%的收率获得5-乙酰基-2-溴吡啶
参考文献:Synthesis Of New N-Arylpyrimidin-2-Amine Derivatives Using A Palladium Catalyst
标题:Synthesis Of New N-Arylpyrimidin-2-Amine Derivatives Using A Palladium Catalyst
摘要:通过应用优化的buchwald-Hartwig氨基化条件,使用二氯双(三苯基膦)钯(II),Xantphos和叔丁醇钠,在氮气氛围下于回流甲苯中,从相应的胺合成了新型n-芳基-4-(吡啶-3-基)嘧啶-2-胺衍生物.所得到的n-芳基衍生物产率从中等到非常好,范围在27%至82%之间.描述的程序可广泛用于制备新型杂环化合物.新化合物的结构通过ft-NMR,Ft-Ir和元素分析得到了确认.
Doi:10.3390/molecules13040818

专利信息

专利号:WO-2021097139-A1
优先权日:2019-11-15
标 题 :Chiral synthesis of a tertiary alcohol

专利号:US-2007275968-A1
优先权日:2004-09-07
标 题 :Substituted Biphenyl Derivative
发明人：KURATA HITOSHI; NISHIMATA TOYOKI; WATANABE YUKIKO; EBISAWA MASAYUKI; FUJIMOTO TEPPEI; KOBAYASHI HIDEKI
权利人:KURATA HITOSHI; NISHIMATA TOYOKI; WATANABE YUKIKO; EBISAWA MASAYUKI; FUJIMOTO TEPPEI; KOBAYASHI HIDEKI
摘要:The present invention relates to a biaryl derivative or a pharmacologically acceptable salt thereof having an excellent collagen-synthesis inhibition activity. A biaryl derivative having a structure represented by the following General Formula (I) or a pharmacologically acceptable salt thereof: n nwherein n R 1 represents a C 6 -C 10 aryl group which is substituted with one to three group(s) each independently selected from the group consisting of a group defined by formula R-L-, a di-(C 1 -C 6 alkyl)amino group, a di-(C 1 -C 6 alkyl)aminosulfonyl group, a hydroxyaminocarbonyl group, and a halogen atom, and so on; R represents a C 1 -C 6 alkyl group, and so on; L represents a sulfonyl group, an aminosulfonyl group, or a sulfonylamino group, and so on; R 2 represents a hydrogen atom, and so on; A represents a group defined by formula (II), (III), or (IV); R 3 represents a C 1 -C 6 alkyl group, and so on; and R 4 represents a C 1 -C 6 alkyl group, and so on.