CAS: 26530-20-1; 2-Octylisothiazol-3(2H)-One

上下游产品

CAS号108-90-7 氯苯 | CAS号33312-01-5 N,N'-二正辛基-3,3'-... | CAS号95-50-1 邻二氯苯 | CAS号111-86-4 辛胺 | CAS号64359-81-5 4,5-二氯-N-辛基-4-异... | CAS号64359-80-4 4-氯-2-辛基-3(2H)异噻唑酮

3,3'-二硫代二辛基丙酰胺置于氯体系中,用 氯苯 用作溶剂,以87%的收率获得2-辛基-4-异噻唑啉-3-酮
参考文献:一种联产oit和dcoit的方法
标题:一种联产oit和dcoit的方法
摘要:本发明公开了一种联产oit和dcoit的方法.其步骤为:将原料n,N'‑二正辛基‑二硫代二丙酰胺或n‑正辛基‑巯基丙酰胺和溶剂加入到氯化反应釜,通入氯气,反应结束后将反应釜内物料进行固液分离;所得母液进行减压蒸馏,釜残保留备用;所得滤饼转移至中和釜,加入溶剂和碱液进行中和及分液,得到有机层;部分有机层进行水洗,脱溶和过滤,得oit成品;另一部分有机层进行共沸脱水后,与釜残合并,通入氯气氯化,反应结束后所得反应液加入碱液进行中和和过滤;所得滤饼进行重结晶,所得固体经淋洗和干燥,得dcoit成品.本发明在提高了生产效率的同时提高了产品的质量,是一种高效环保的生产方法.

专利信息

专利号:US-12221452-B2
优先权日:2017-10-04
标题:Synthesis of cantharidin
发明人：DAVIDSON MATTHEW GENE; EKLOV BRIAN MATTHEW; WUTS PETER; LOERTSCHER BRAD MELVIN; SCHOW STEVEN R
权利人:VERRICA PHARMACEUTICALS INC
摘要:The invention provides synthetic methods for the preparation of cantharidin and analogs thereof. In one aspect, the invention provides an improved Diels-Alder cycloaddition to generate a key intermediate en route to cantharidin and analogs thereof. In certain embodiments, the new Diels-Alder reaction involves reacting Compound (2) in the presence of furan, and in the absence of acid or increased pressure, in an aprotic polar solvent with slight warming, to yield Compound (1) in favorable yield and exo-endo ratio. In another aspect, the invention also provides a new Diels-Alder reaction between compounds of Formula (III) and furan to yield compounds of Formula (IV), which can then be transformed into cantharidin or analogs thereof. In yet another aspect, the invention describes a new palladium-mediated carbonylation providing another key intermediate en route to cantharidin and analogs thereof. In addition to synthetic methods, present invention also provides compounds (i.e., intermediates) useful in the synthesis of cantharidin and analogs thereof. Compounds provided herein may have biological activity, and therefore may be used in the treatment of diseases or conditions (e.g., infectious diseases and skin conditions).

专利号:US-11155562-B2
优先权日:2014-06-30
标 题 :Synthesis of halichondrin analogs and uses thereof
发明人：KISHI YOSHITO; UEDA ATSUSHI; YAMAMOTO AKIHIKO; KATO DAISUKE
权利人:HARVARD COLLEGE
摘要:The present invention provides halichondrin analogs, such as compounds of Formula (I). The compounds may bind to microtubule sites, thereby inhibiting microtubule dynamics. Also provided are methods of synthesis, pharmaceutical compositions, kits, methods of treatment, and uses that involve the compounds for treatment of a proliferative disease (e.g., cancer). Compounds of the present invention are particularly useful for the treatment of metastatic breast cancer, non-small cell lung cancer, prostate cancer, and sarcoma. The included methods of synthesis are useful for the preparation of compounds of Formula (I)-(III) along with naturally occurring halicondrins (e.g., halichondrin B & C, norhalichondrin A, B, & C, and homohalichondrin A, B, & C). Also included are methods for interconverting between the halichondrins, norhalichondrins, and homohalichondrins and their unnatural epimers at the C38 ketal stereocenter through the use of an acid-mediated equilibration.

专利号:US-9982005-B2
优先权日:2013-04-04
标 题 :Macrolides and methods of their preparation and use
发明人：MYERS ANDREW G; SEIPLE IAN BASS; ZHANG ZIYANG
权利人:HARVARD COLLEGE
摘要:Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.

专利号:WO-2025007089-A1
优先权日:2023-06-30
标 题:Compositions, methods and kits for nucleic acids synthesis and amplification
发明人：BERKMAN JENNIFER; URBONAS IGNAS; ABREU DANIELA CRUZ; LIU CHENGJING; YEN CHIA AN; ONG KIMBERLIE SOOHOO; WEI WEI; GOMEZ SILVAN MARIA CINTA
权利人:LIFE TECHNOLOGIES CORP; THERMO FISHER SCIENTIFIC BALTICS UAB
摘要:The present disclosure is directed to compositions, methods and kits useful for the synthesis of nucleic acid molecules. More specifically, compositions, methods and kits are provided for the amplification of nucleic acid molecules in an one-step qPCR or RT-qPCR procedure comprising a reverse transcriptase, a DNA polymerase, at least one dNTP, and at least one stabilizing agent, wherein said at least one stabilizing agent increases stability of an assembled polymerase chain reaction.

专利号:US-2014378538-A1
优先权日:2011-12-14
标 题:Methods of responding to a biothreat
发明人：BANCEL STEPHANE
权利人:MODERMA THERAPEUTICS INC
摘要:The present disclosure provides for devices, in particular mobile devices, which may be used in the synthesis of modified nucleic acid molecules, in particular modified mRNA molecules. The device for making the modified nucleosides, modified nucleotides and modified nucleic acids (e.g., mRNA) disclosed herein may be mobile devices comprising at least one sample block for insertion of one or more sample vessels, a device base with electronic control units for the sample block, a voltage supply, and one or more reagent(s) for the synthesis of at least one nucleic acid.

专利号:US-9005895-B2
优先权日:2010-06-21
标题:Compositions, methods and kits for nucleic acid synthesis and amplification
发明人：WOO CORA L; BERKMAN JENNIFER; YIM PRISCILLA W
权利人:WOO CORA L; BERKMAN JENNIFER; YIM PRISCILLA W; LIFE TECHNOLOGIES CORP
摘要:The present invention is directed to compositions, methods and kits useful for the synthesis of nucleic acid molecules. More specifically, compositions, methods and kits are provided for the amplification of nucleic acid molecules in a one-step RT-PCR procedure comprising one or more agents used to increase tolerance to PCR inhibitors.