CAS: 34316-15-9; 1,2-Dimethoxy-12-Methyl-[1,3]Dioxolo[4',5':4,5]Benzo[1,2-C]Phenanthridin-12-Ium

上下游产品

CAS号87264-52-6 all°Cryptopine ... | CAS号21080-31-9 Angoline | CAS号28342-33-8 氧基白屈菜季铵碱 | CAS号6880-91-7 二氢白屈菜红碱

6-Bromo-N-(6-Bromo-2,3-Dimethoxybenzyl)Naphtho[2,3-D][1,3]Dioxol-5-Amine置于palladium Bis[bis(Diphenylphosphino)Ferrocene] Dichloride,碘,Potassium Acetate,Sodium Acetate,Sodium Hydride,联硼酸频那醇酯体系中,用 乙醇,二甲基亚砜,N,N-二甲基甲酰胺 用作溶剂,化学反应 23.5H,反应生成白屈菜红碱
参考文献:二氢白屈菜红碱及其衍生物:合成及其作为潜在的g-四链体dna稳定剂的应用
标题:二氢白屈菜红碱及其衍生物:合成及其作为潜在的g-四链体dna稳定剂的应用
摘要:设想了通过原位产生的芳基硼烷的2-溴-N-(2-溴苄基)-萘-1-胺衍生物5的分子内铃木偶联来合成二氢白屈菜红碱(dhchl)4的便利途径.将该化合物转化为(+/-)-6-丙酮基二氢白屈菜红碱(adc)3,然后通过手性制备型HPLC对其进行拆分.Dhchl稳定启动子四链dna结构的效率以及与母体天然生物碱白屈菜红碱(chl)的比较研究,1被执行了.通过使用各种生物物理和生化研究进行了彻底的研究以评估四链体结合亲和力,并且通过使用分子建模和动力学研究来解释了结合模式.结果清楚地表明dhchl是一种强g-四链体稳定剂,其亲和力类似于亲本生物碱chl的亲和力.还针对不同的人类癌细胞系筛选了化合物adc和dhchl.在癌细胞中,(+/-)-Adc及其对映异构体显示出对人结肠直肠细胞系hct116和乳腺癌细胞系mda-Mb-231的不同抑制作用(15-48%),尽管对映体的抑制作用很低.而dhchl 仅显示
Doi:10.1016/j.Bmc.2016.04.059

专利信息

专利号:US-2019209521-A1
优先权日:2006-07-28
标 题:Methods of stimulating cellular growth, synaptic remodeling and consolidation of long term memory
发明人：ALKON DANIEL
权利人:COGNITIVE RES ENTERPRISES INC
摘要:The present invention provides methods of slowing or reversing the loss of memory and learning comprising the steps of contacting an effective amount of a PKC activator with a protein kinase C (PKC) in a subject identified with memory loss slowing or reversing memory loss. The present invention provides methods of stimulating cellular growth, neuronal growth, dendritic growth, dendritic spine formation, dendritic spine density, and the translocation of ELAV to proximal dendrites, and synaptic remodeling. The present invention also provides methods of contacting a protein kinase C (PKC) activator with a PKC activator in a manner sufficient to stimulate the synthesis of proteins sufficient to consolidate long-term memory. The present invention also provides methods of contacting a protein kinase C (PKC) activator with a PKC activator in a manner sufficient to downregulate PKC.

专利号:US-2013331427-A1
优先权日:2006-07-28
标题:Methods of stimulating cellular growth, synaptic, remodeling and consolidation of long-term memory
发明人：ALKON DANIEL L
权利人:BRNI NEUROSCIENCES INST; BRNI NEUROSCIENCES INST
摘要:The present invention provides methods of slowing or reversing the loss of memory and learning comprising the steps of contacting an effective amount of a PKC activator with a protein kinase C (PKC) in a subject identified with memory loss slowing or reversing memory loss. The present invention provides methods of stimulating cellular growth, neuronal growth, dendritic growth, dendritic spine formation, dendritic spine density, and the translocation of ELAV to proximal dendrites, and synaptic remodeling. The present invention also provides methods of contacting a protein kinase C (PKC) activator with a PKC activator in a manner sufficient to stimulate the synthesis of proteins sufficient to consolidate long-term memory. The present invention also provides methods of contacting a protein kinase C (PKC) activator with a PKC activator in a manner sufficient to downregulate PKC.

专利号:EP-0354945-B1
优先权日:1988-01-13
标 题 :Process for the enhancement of enzyme activities and synthetic efficiency in microorganisms and higher plants
发明人：FIEDLER FRANZ; ZENK MEINHART H; GUNDLACH HEIDRUN; WEBER ALFRED; KENNECKE MARIO
权利人:SCHERING AG
摘要:In the process disclosed, the organisms are brought into contact witn inactivated elicitor-containing microorganisms, fragments of the latter, or excretions of elicitor-containing microorganisms. Only inactivated elicitor-containing bacteria, fragments of the latter, or excretions of elicitor-containing bacteria may be used to activate enzymes and promote synthesis in non-microbial organisms. The process can be used, for example, to promote synthesis in microorganisms or plants which produce pigments, antibiotics, alkaloids or phytoalexins or to activate enzymes in microorganisms capable of transforming steroids.

专利号:WO-2020107548-A1
优先权日:2018-11-27
标 题:Highly efficient method for catalyzing synthesis of sanguinarine and chelerythrine

专利号:US-7989004-B2
优先权日:2004-05-27
标题:Antitubercular extracts of Salicornia brachiata
发明人：RATHOD MEENA RAJNIKANT; SHETHIA BHUPENDRA DHANVANTRAI; PANDYA JAYANT BATUKRAL; GHOSH PUSHPITO KUMAR; DODIA PRAKASH JAGIVANBHAL; SRIVASTAVA BRAHM S; SRIVASTAVA RANJANA; SRIVASTAVA ANIL; CHATURVEDI VINITA; VAIRAMANI MARIAPPANADAR
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to enhancement of anti-tubercular activity of active fraction isolated from Salicornia brachiata . The invention also discloses the non-toxic nature of the fraction and positively identifies Sucrose as its main constituent. Pure Sucrose is shown to have no anti-tubercular activity indicating thereby that activity of the fraction resides in one or more of the minor constituents. The minor constituents are shown to be relatively low molecular weight entities and a chromatographic technique is disclosed for separating them from the bulk sucrose to probe their activities and structures in detail, as also the possibility of their synthesis if the leads thrown up are novel.

专利号:US-2024208898-A1
优先权日:2021-03-25
标 题 :Enamine n-oxides: synthesis and application to hypoxia-responsive prodrugs and imaging agents
发明人：KIM JUSTIN; KANG DAHYE; CHEUNG SHELDON T
权利人:DANA FARBER CANCER INST INC
摘要:Disclosed are compounds and pharmaceutically acceptable salts and stereoisomers thereof that are suitable for diagnosis and the treatment of diseases and disorders characterized by, associate with or which exhibit tissue hypoxia, such as, for example, solid tumors. Also disclosed are pharmaceutical compositions containing same, and methods of making and using the compounds.