CAS: 356560-80-0; 6-Bromo-[1,2,4]Triazolo[1,5-A]Pyridine

该化合物是一种环球化合物,其组成为三甲苯-核心,具有溴替代成分,这种结构将多功能作为制药和农用化学合成的关键中间体,特别是在开发活性成分方面.溴原子提供了一个反应反应的被动站点,通过相互交织的结合,如Suzuki 或 Buchwald-Hartwig 组合,进一步发挥作用,从而能够进行精确的结构改变. 在标准条件下,它稳定且与各种反应条件相容,使它成为医药化学和材料科学应用的可靠建筑块.该化合物定义明确的再活动特征可以确保复杂的合成路径的一贯性.

英文名称6-Bromo-[1,2,4]Triazolo[1,5-A]Pyridine
中文名称6-溴-[1,2,4]三唑并[1,5-a]吡啶
IUPAC名称6-bromo-[1,2,4]triazolo[1,5-a]pyridine
其它别名4]三唑并[1; 6-Bromo-[1,2,4]Triazolo[1,5-A]Pyridine
CAS编号356560-80-0
MFCD编号:MFCD08689534
EINECS号:801-547-5
分子式:C6H4BrN3
分子量:198.02
产品CID: 1364880
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
InChIKey: CXRXKDSDRWLKTK-UHFFFAOYSA-N
InChI=1S/C6H4BrN3/c7-5-1-2-6-8-4-9-10(6)3-5/h1-4H…
计算化学: 氢键受体数3.0氢键供体数0.0可旋转键数0.0

相似化合物

868362-18-9 1310680-10-4 1401624-81-4

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
急性毒性类别4(经口)
严重眼刺激类别2A
警示词Warning(警告)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H302 |吞咽有害.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
UN编号NONH for all modes of transport
危险品标志Xi,Xn
风险等级Harmful/Irritant/Keep Cold
安全声明26-24/25
危险类别码22-36/37/38
WGK Germany3

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号138888-98-9 N'-(5-溴吡啶-2-基)-... | CAS号1075260-65-9 N-(5-bromo-2-py... | CAS号1072-97-5 2-氨基-5-溴吡啶 | CAS号1160790-18-0 9-氮杂吲哚-5-硼酸频哪醇酯 | CAS号943845-23-6 [1,2,4]三唑并[1,5-...

合成工艺路线路线简述

N-(5-Bromo-2-Pyridinyl)Imidoformamide置于吡啶,Hydroxylamine-O-Sulfonic Acid体系中,用甲醇作为反应溶剂,化学反应生成 6-溴-[1,2,4]三唑并[1,5-A]吡啶
参考文献:Wo2008/128953
标题:Wo2008/128953

海关参考信息

2933310010-吡啶
2939800000-其他生物碱
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-2012077802-A1
优先权日:2009-06-10
标题 :Histamine h3 inverse agonists and antagonists and methods of use thereof
发明人：CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN
权利人:CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are spiro-cyclic compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including, e.g., neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as, e.g., histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical compositions containing the compounds and their methods of use are also provided herein.

专利号:US-8404670-B2
优先权日:2009-02-11
标题:Histamine H3 inverse agonists and antagonists and methods of use thereof
发明人：CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SPEAR KERRY L
权利人:CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SPEAR KERRY L; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.