CAS: 38041-19-9; Tetrahydro-2H-Pyran-4-Amine

相似化合物

33024-60-1 220641-87-2 693245-65-7

上下游产品

CAS号61128-73-2 二氢-2H-吡喃-4(3h)-酮 肟 | CAS号29943-42-8 四氢吡喃酮 | CAS号116312-69-7 1-(四氢-2H-吡喃-4-基)肼盐酸盐 | CAS号2081-44-9 四氢吡喃-4-醇 | CAS号1080028-76-7 双(4-四氢吡喃基)胺 | CAS号344329-76-6 4-甲酰胺基吡喃 | CAS号5337-03-1 四氢吡喃-4-甲酸 | CAS号60-29-7 乙醚 | CAS号33024-60-1 4-氨基四氢吡喃盐酸盐 | CAS号38035-10-8 4-(二甲基氨基)四氢-2H-吡喃 | CAS号220641-87-2 N-甲基四氢-2H-吡喃-4-胺 | CAS号1184916-08-2 2-Chloro-6-meth... | CAS号874888-83-2 N-[(3-nitrophen... | CAS号874888-85-4 N-methyl-N-[(3-... | CAS号874888-87-6 N-[(3-aminophen... | CAS号656239-37-1 N-(四氢-2H-吡喃-4-基... | CAS号449811-92-1 6-(2,4-二氟苯氧基)-8...

四氢吡喃酮置于ammonium Hydroxide,Nickel-Aluminum Alloy,水体系中,化学反应 2.0H,以90%的收率获得产物4-氨基四氢吡喃
参考文献:Ni-Al合金在水和氢源中的羰基化合物非均相催化还原胺化反应
标题:Ni-Al合金在水和氢源中的羰基化合物非均相催化还原胺化反应
摘要:‡这些作者对这项工作做出了同等贡献. 抽象的 羰基化合物的多相催化还原胺化反应通过氢氧化铵和各种胺与酮和醛的反应实现的.该方法基于阮内型镍铝合金在水性介质中的应用.羰基化合物与胺的反应提供相应的席夫碱,其立即进行还原以提供伯胺和仲胺作为产物.合金中al的含量与溶剂水的受控反应反应生成氢,原位形成的raney Ni®用作氢化催化剂.该方法是制备多种伯胺和仲胺的简单有效的方法. 羰基化合物的多相催化还原胺化反应通过氢氧化铵和各种胺与酮和醛的反应实现的.该方法基于阮内型镍铝合金在水性介质中的应用.羰基化合物与胺的反应提供相应的席夫碱,其立即进行还原以提供伯胺和仲胺作为产物.合金中al的含量与溶剂水的受控反应反应生成氢,原位形成的raney Ni®用作氢化催化剂.该方法是制备多种伯胺和仲胺的简单有效的方法.
DOI:10.1055/s-0035-1561647

专利信息

专利号:US-2025049791-A1
优先权日:2023-08-03
标题:Synthesis of MEK7 Inhibitors and methods of Use Thereof
发明人：SCHEIDT KARL A; KIM DALTON ROBERT; ORR MEGHAN JO
权利人:UNIV NORTHWESTERN
摘要:Disclosed herein are 4-phenoxypyrimidine compounds and derivatives thereof for use as inhibitors of mitogen-activated protein kinase 7 (MEK7). The disclosed compounds and pharmaceutical compositions thereof may be used in methods for treating a disease or disorder associated with MEK7 activity, including cell proliferative diseases and disorders associated with MEK7 activity, such as cancer.

专利号:US-8188113-B2
优先权日:2006-09-14
标 题 :Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C; DECIPHERA PHARMACEUTICALS INC
摘要:The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

专利号:WO-2024028893-A1
优先权日:2022-08-01
标 题:Substituted benzimidazoles for treating viral diseases
发明人：CHAUDHARI VINOD DINKAR; THAKUR KRISHAN GOPAL; RINGE RAJESH PRAKASH; SINGH DESHKANWAR; KAUR SIMRAN; CHAWLA RAVNEET SINGH; JOSHI AKSHAY
权利人:COUNCIL OF SCIENT AND INDUSTRIAL RESEARCH AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGN OF S
摘要:The invention relates to benzimidazole compounds, pharmaceutically acceptable salts thereof and its pharmaceutical compositions for reducing/treating viral infections. The present invention also relates to synthesis of such benzimidazole compounds. The present invention further relates to compositions which comprise such benzimidazole compounds or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, optionally in combination. The compounds of the invention are useful in reducing/treating viral infections particularly coronavirus infections caused by SARS-CoV, MERS-CoV and SARS-CoV-2.

专利号:US-2022281888-A1
优先权日:2019-09-25
标题:Bicyclic carboxylates as modulators of transporters and uses thereof
发明人：SANDANAYAKA VINCENT; GORECZNY GREGORY
权利人:NIROGY THERAPEUTICS INC
摘要:The present invention generally relates to the field of transporter modulators, e.g., monocarboxylate transporter inhibitors, and more particularly to new bicyclic enone carboxylate compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with monocarboxylate transporter activity such as in treating cancer and other neoplastic disorders, tissue and organ transplant rejection.

专利号:US-2022267331-A1
优先权日:2019-06-05
标题 :Dopamine-b-hydroxylase inhibitors
发明人：KISS LASZLO; BELIAEV ALEXANDER; ROSSI TINO; PALMA NUNO; SOARES DA SILVA PATRÃ?CIO; PINTO RUI; CARDONA FRANCISCO
权利人:BIAL PORTELA & CA SA
摘要:This invention relates to: (a) compounds of formula I (with R1 to R5 and A as defined herein) and pharmaceutically acceptable salts or solvates thereof that are useful as dopamine-β-hydroxylase inhibitors; (b) pharmaceutical compositions comprising such compounds, salts or solvates; (c) the use of such compounds, salts or solvates in therapy; (d) therapeutic methods of treatment using such compounds, salts or solvates; and (e) processes and intermediates useful for the synthesis of such compounds.

专利号:US-7468375-B2
优先权日:2004-04-26
标题:Inhibitors of the HIV integrase enzyme
发明人：DRESS KLAUS RUPRECHT; HU QIYUE; JOHNSON TED WILLIAM; PLEWE MICHAEL BRUNO; TANIS STEVEN PAUL; WANG HAI; YANG ANLE; YIN CHUNFENG; ZHANG JUNHU
权利人:PFIZER
摘要:The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIVâ€?) integrase enzyme.