CAS: 38377-38-7; 4-Fluorophenyl Carbonochloridate

上下游产品

4-Fluorophenol bis(trichloromethyl) carbonate trichloromethyl chloroformate 5-(Methoxyimino-methyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid 4-fluoro-phenyl ester 4-(tert-Butyl-dimethyl-silanyloxymethyl)-2-ethynyl-2H-quinoline-1-carboxylic acid 4-fluoro-phenyl ester bis(4-fluorophenyl) carbonate

4-氟苯酚,三光气置于n,N-二乙基苯胺体系中,用 甲苯 用作溶剂,化学反应 2.0H,反应生成氯甲酸-4-氟苯酯
参考文献:可见光诱导的分子内c(sp 2)-h胺化和叠氮基甲酰胺通过三重态硝基途径的叠氮化
标题:可见光诱导的分子内c(sp 2)-h胺化和叠氮基甲酰胺通过三重态硝基途径的叠氮化
摘要:邻烯丙基苯基叠氮基甲酸酯的催化分子内c-h氨基化和叠氮化反应已在可见光照射下完成,为合成有用的苯并恶唑酮和[5.1.0]双环氮丙啶提供了温和,清洁和有效的方法.机理研究表明,三重态氮烯起反应性中间体的作用.与烷基烯烃叠氮化≫缺电子烯烃叠氮化~c(sp 2)-h胺化≫ C(sp 3)-h胺化反应的化学选择性,在理解可见光方面可能具有指导意义诱导的三重态氮转化反应.
Doi:10.1021/acs.Orglett.8B01980

专利信息

专利号:US-8377406-B1
优先权日:2012-08-29
标 题 :Synthesis of bis(fluorosulfonyl)imide
发明人：SINGH RAJENDRA P; MARTIN JERRY LYNN; POSHUSTA JOSEPH CARL
权利人:BOULDER IONICS CORP; SINGH RAJENDRA P; MARTIN JERRY LYNN; POSHUSTA JOSEPH CARL
摘要:The present invention provides methods for producing bis(fluorosulfonyl) compounds of the formula:n nF—S(O) 2 —Z—S(O) 2 —F  In nby contacting a nonfluorohalide compound of the formula:n nX—S(O) 2 —Z—S(O) 2 —Xn nwith bismuth trifluoride under conditions sufficient to produce the bis(fluorosulfonyl) compound of Formula I, where Z and X are those defined herein.

专利号:US-9453037-B2
优先权日:2011-07-28
标 题 :Methylphenidate-prodrugs, processes of making and using the same
发明人：GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB
权利人:KEMPHARM INC; KEMPHARM INC
摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.

专利号:US-5132468-A
优先权日:1990-01-19
标题 :C-alkylation of hydroquinone or monoethers thereof
发明人：DOUSSAIN CLAUDE; GUBELMANN MICHEL; TIREL PHILIPPE-JEAN
权利人:RHONE POULENC CHIMIE
摘要:The alkyl hydroquinones, e.g., methyl hydroquinone (a useful intermediate in the preparation of the monomer methyl hydroquinone diacetate, itself used for the synthesis of thermotropic polymers), are prepared by reacting (C-alkylating) hydroquinone or a monoether thereof with a lower alkanal, in the vapor phase, with a catalytically effective amount of at least one solid metal oxide.

专利号:US-9895454-B2
优先权日:2014-07-03
标题:Metal oxide catalyzed radiofluorination
发明人：SERGEEV MAXIM; MORGIA FEDERICA; VAN DAM ROBERT MICHAEL; LAZARI MARK
权利人:UNIV CALIFORNIA
摘要:Inter alia, the first titania-catalyzed [ 18 F]-radiofluorination in highly aqueous medium is provided. In embodiments, the method utilizes titanium dioxide, 1:1 acetonitrile-thexyl alcohol solvent mixture and tetrabutylammonium bicarbonate as a base. Radiolabeling may be directly performed with aqueous [ 18 F]fluoride without the need for drying/azeotroping step, which reduces radiosynthesis time while keeping high fluoride conversion. The general applicability of the synthetic strategy to the synthesis of the wide range of PET probes from tosylated precursors is demonstrated.

专利号:US-5521179-A
优先权日:1991-04-18
标题 :Heterocyclic amides
发明人：BERNSTEIN PETER R; SHAW ANDREW; THOMAS ROYSTON M; WARNER PETER; WOLANIN DONALD J
权利人:ZENECA LTD
摘要:The present invention relates to certain novel heterocyclic amides which are 1-pyridylacetamide compounds of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic amides, processes for preparing the heterocyclic amides, pharmaceutical compositions containing such heterocyclic amides and methods for their use.

专利号:AU-2013309495-A1
优先权日:2012-08-29
标题 :Synthesis of bis(fluorosulfonyl)imide