专利号:US-2014349347-A1 优先权日:2011-12-15 标题:Synthesis of n-acetyl-d-neuraminic acid 发明人:SCHROVEN ANDREAS; DEKANY GYULA; VRASIDAS IONNIS 权利人:SCHROVEN ANDREAS; DEKANY GYULA; VRASIDAS IONNIS; GLYCOM AS 摘要:Method of making NANA from NAM, which may itself be made from fructose. The NAM is treated with pyruvic acid or a pyruvate in the presence of a NANA aldolase having at least 70% sequence similarity or homology to the amino acid sequence of SEQ. ID. NO. 1.
专利号:US-8076496-B2 优先权日:2000-03-16 标题:Chemoselective ligation 发明人:SAXON ELIANA; BERTOZZI CAROLYN RUTH 权利人:SAXON ELIANA; BERTOZZI CAROLYN RUTH; UNIV CALIFORNIA 摘要:The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between the two reactive partners resulting in a final product comprising a phosphine moiety, or which can be engineered to comprise a cleavable linker so that a substituent of the phosphine is transferred to the azide, releasing an oxidized phosphine byproduct and producing a native amide bond in the final product. The selectivity of the reaction and its compatibility with aqueous environments provides for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).
专利号:WO-2013088267-A1 优先权日:2011-12-15 标题 :Synthesis of n-acetyl-d-neuraminic acid
专利号:EP-2791349-A1 优先权日:2011-12-15 标 题:Synthesis of n-acetyl-d-neuraminic acid
专利号:CN-118979085-A 优先权日:2023-05-11 标 题 :Synthesis process of 9-azido-9-deoxy-N-glycolylneuraminic acid
1. Liu J, Numa MM, Liu H, Huang SJ, Sears P, Shikhman AR, Wong CH. Synthesis and high-throughput screening of N-acetyl-beta-hexosaminidase inhibitor libraries targeting osteoarthritis. J Org Chem. 2004 Sep 17;69(19):6273-83. doi: 10.1021/jo049355h.
合成参考文献
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