CAS: 570406-98-3; 1-(3-Chloro-5-((4-(4-Chlorothiophen-2-yl)-5-(4-Cyclohexylpiperazin-1-yl)Thiazol-2-yl)Carbamoyl)Pyridin-2-yl)Piperidine-4-Carboxylic Acid

上下游产品

Ethyl 1-(3-Chloro-5-{[4-(4-Chlorothiophen-2-yl)-5-(4-Cyclohexylpiperazin-1-yl)Thiazol-2-Yl]Carbamoyl}Pyridin-2-yl)Piperidine-4-Carboxylate
4-(4-Chloro-2-Thienyl)-5-(4-Cyclohexyl-1-Piperazinyl)-2-Thiazolamine

1-[3-Chloro-5-[[[4-(4-Chloro-2-Thienyl)-5-(4-Cyclohexyl-1-Piperazinyl)-2-Thiazolyl]Amino]Carbonyl]-2-Pyridyl]-4-Piperidinylcarboxylic Acid Methyl Ester置于水,Lithium Hydroxide体系中,用 四氢呋喃 作为反应溶剂,化学反应 8.0H,以92.4%的收率获得产物1-[3-氯-5-[[[4-(4-氯-2-噻吩基)-5-(4-环己基-1-哌嗪基)-2-噻唑基]氨基]羰基]-2-吡啶基]-4-哌啶羧酸
参考文献:阿曲波帕的制备方法
标题:阿曲波帕的制备方法
摘要:本发明揭示了一种阿曲波帕(Avatrombopag)的制备方法,以6‑氨基‑5‑氯‑3‑吡啶苯甲酸为起始原料,依次进行环化,酰胺化和水解等反应,制得目标产物阿曲波帕.该制备过程原料易得,快捷方便,经济环保,尤其克服了现行工艺原料中双氯选择性差等问题,适于大规模工业化生产.

专利信息

专利号:US-11623103-B2
优先权日:2014-09-24
标 题 :Systems and methods for enhancing platelet biogenesis and extending platelet lifespan with low level light
发明人：WU MEIXIONG; ZHANG QI
权利人:MASSACHUSETTS GEN HOSPITAL
摘要:The present disclosure is directed to systems and methods that can apply low level light (LLL) to facilitate platelet biogenesis or extend platelet lifespan. While not wishing to be bound by theory, it is believed that LLL can enhance the ATP synthesis by the mitochondria within platelets and/or platelet precursor cells, which, thereby, helps to enhance platelet biogenesis and extend the platelet lifespan. In some instances, LLL can facilitate in vitro and/or in vivo platelet biogenesis. In other instances, LLL can extend platelet lifespan in circulation. In still other instances, LLL can be employed to prolong the shelf-life of stored platelets.