专利号:US-7030218-B2 优先权日:2000-09-08 标 题 :Pseudo native chemical ligation 发明人:HUNTER CHRISTIE L; BOTTI PAOLO; BRADBURNE JAMES A; CHEN SHIAH-YUN; CRESSMAN SONYA; KENT STEPHEN B H; KOCHENDOERFER GERD G; LOW DONALD W 权利人:GRYPHON THERAPEUTICS 摘要:The present invention concerns methods and compositions for extending the technique of native chemical ligation of a wider range of peptides, polypeptides, other polymers and other molecules via an amide bond (see FIG. 1 ). The invention further provides methods and uses for such proteins and derivatized proteins. The invention is particularly suitable for use in the synthesis of optionally polymer-modified, synthetic bioactive proteins, and of pharmaceutical compositions that contain such proteins.
专利号:CN-105085379-A 优先权日:2014-05-15 标 题:Synthesis of aryl-linked bisphenoxides and their use in activator-supported olefin polymerization catalyst systems
专利号:US-2025250673-A1 优先权日:2021-11-11 标题 :ALD Deposition Utilizing MoO2Cl2 and MoO2Br2 发明人:MILLER MICHAEL; HIGUCHI RANDALL; NGO THONG; AZCATL-ZACATZI ANGELICA; LEI XINJIAN 权利人:VERSUM MAT US LLC 摘要:The disclosed and claimed subject matter relates to atomic layer deposition (ALD) of 2D MoX 2 (X=S, Se or Te) utilizing one or more of MoO 2 Cl 2 and MoO 2 Br 2 as the Mo-precursor with alkyl-chalcogenide, alkyl-dichalcogenide, and/or dihydro-chalcogenide precursors while maintaining the process in a self-limiting-layer-synthesis growth mode or a self-limiting-layer-synthesis-like growth mode.
专利号:US-8304451-B2 优先权日:2006-05-03 标题 :Histone deacetylase and tubulin deacetylase inhibitors 发明人:MAZITSCHEK RALPH; KWIATKOWSKI NICHOLAS PAUL; BRADNER JAMES ELLIOT 权利人:MAZITSCHEK RALPH; KWIATKOWSKI NICHOLAS PAUL; BRADNER JAMES ELLIOT; HARVARD COLLEGE; DANA FARBER CANCER INST INC 摘要:In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel inhibitors of histone deacetylases, tubulin deacetylases, and/or aggresome inhibitors, and pharmaceutically acceptable salts and derivatives thereof. The inventive compounds fall into two classes—“isotubacinâ€? class and “isoisotubacinâ€? class—all of which include a 1,3-dioxane core. The present invention further provides methods for treating disorders regulated by histone deacetylase activity, tubulin deacetylase activity, and/or the aggresome (e.g., proliferative diseases, cancer, inflammatory diseases, protozoal infections, protein degradation disorders, protein deposition disorders, etc.) comprising administering a therapeutically effective amount of an inventive compound to a subject in need thereof. The present invention also provides methods for preparing compounds of the invention.
摘要:Archives Internationales de Pharmacodynamie et de Therapie., 12(447), 1904 摘要:Jończyk, A.; Kowalkowska, A., Science of Synthesis, (2006) 8, 1036. 摘要:García Ruano, J. L.; Cid, M. B.; Martín-Castro, A. M.; Alemán, J., Science of Synthesis, (2008) 39, 271.