CAS: 6240-11-5; 1-Adamantaneethanol

相似化合物

4942-47-6 770-71-8 29817-45-6

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CAS号29817-45-6 2-(1-ADAMANTANY... | CAS号27174-71-6 1-金刚烷乙酸甲酯 | CAS号4942-47-6 1-金刚烷乙酸 | CAS号51849-10-6 1-(碘甲基)金刚烷 | CAS号41100-45-2 1-氨基-3-乙基金刚烷盐酸盐 | CAS号828-51-3 1-金刚烷甲酸 | CAS号878-61-5 1-溴-3-乙基金刚烷 | CAS号773-37-5 1-(2-溴乙基)金刚烷 | CAS号770-69-4 1-乙基金刚烷 | CAS号101479-70-3 2-(1-adamantyl)... | CAS号1283719-69-6 Tricyclo[3.3.1....

1-Adamanthylethyl Acetate置于甲醇,Potassium Permanganate,三甲基碘化锍体系中,25.0 °C,101.33 Kpa 条件下,以96%的收率获得产物1-金刚烷乙醇
参考文献:Me3Si 促进的化学选择性脱乙酰化:一般和温和的方案.
标题:Me3Si 促进的化学选择性脱乙酰化:一般和温和的方案.
摘要:通过使用 Kmno4 作为添加剂,开发了一种 Me3Si 介导的简单而有效的乙酰基化学选择性脱保护方案.这种化学选择性脱乙酰化适用于多种底物,可耐受碳水化合物,氨基酸,天然产物,杂环化合物和一般支架中的多种敏感官能团.该协议很有吸引力,因为它使用环境友好的试剂系统在环境条件下进行定量和清洁转化.
DOI:10.1039/d1Ra03209G

专利信息

专利号:US-11912647-B2
优先权日:2020-05-22
标 题:Diversity-oriented synthesis of N,N,O-trisubstituted hydroxylamines from alcohols and amines by N—O bond formation
发明人：CRICH DAVID; HETTIKANKANAMALAGE ASIRI; HILL JARVIS
权利人:UNIV GEORGIA
摘要:In one aspect, the disclosure relates to a method for the direct synthesis of complex N,N,O-trisubstituted hydroxylamines by N—O bond formation. In another aspect, the method can successfully be employed using a wide variety of commercially available alcohols and secondary amines and enables the construction of large fragment-based libraries of trisubstituted hydroxylamines for drug discovery purposes. Also disclosed are N,N,O-trisubstituted hydroxylamines having low basicity, high stability at ambient temperatures, and an inherent lack of reactivity towards acetylating and sulfonylating enzymes that confer mutagenicity on less-substituted hydroxylamines.

专利号:US-6906046-B2
优先权日:2000-12-22
标题 :Pharmaceutical uses and synthesis of benzobicyclooctanes
发明人：JACKSON RANDY W; DARWISH IHAB; BAUGHMAN TED A; HOWBERT J JEFFRY
权利人:CELLTECH R & D INC
摘要:Benzobicyclooctane compounds, their use in inhibiting cellular events involving TNF-α and IL-8, and in the treatment of inflammation events in general; a combinatorial library of diverse bicyclooctanes and process for their synthesis as a library and as individual compounds.

专利号:US-2004053999-A1
优先权日:1997-09-17
标题 :Novel compounds and methods for synthesis and therapy
发明人：BISCHOFBERGER NORBERT W; DAHL TERRENCE C; HITCHCOCK MICHAEL J M; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; MILLS ROGER G; WILLIAMS MATTHEW A
摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

专利号:US-6225341-B1
优先权日:1995-02-27
标 题:Compounds and methods for synthesis and therapy
发明人：BISCHOFBERGER NORBERT W; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; WILLIAMS MATTHEW A
权利人:GILEAD SCIENCES INC
摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

专利号:US-3668220-A
优先权日:1967-10-13
标 题:Adamantane compounds
发明人：SZINAI STEPHEN S; LUNN WILLIAM H W
权利人:LILLY CO ELI
摘要:WHEREIN EACH G independently represents hydrogen or straightchain alkyl of from one to six, both inclusive, carbon atoms; G'' represents hydrogen or acetyl; R represents hydrogen or alkyl of from one to six, both inclusive, carbon atoms; R'' represents halo, alkoxy containing from one to six both inclusive, carbon atoms in the alkyl group, hydrogen or alkyl of from one to six, both inclusive, carbon atoms; each R'''' independently represents hydrogen or alkyl of from one to six, both inclusive, carbon atoms; each R'''''' independently represents hydrogen or alkyl of from one to six, both inclusive, carbon atoms or both R'''''' groups taken together represent oxo(-0); X represents halo; and each n independently represents an integer of from zero to one, both inclusive. The terms ''''halo'''' and ''''halide'''' are employed herein to designate occurrences of bromine, chlorine and iodine. The adamantane compounds of formula VII AND VIII are useful as agents to achieve a depressant action on the central nervous system of warm blooded animals. The adamantane compounds of formulas I, II, III, IV, V and VI are useful as intermediates in the synthesis of the compounds of formulas VII and VIII. The present invention is directed to adamantane compounds of the formula:

专利号:US-3859352-A
优先权日:1966-10-24
标题 :Adamantane compounds
发明人：SZINAI STEPHEN S; LUNN WILLIAM H W
权利人:LILLY CO ELI
摘要:The present invention is directed to adamantane compounds of the formulae: WHEREIN EACH G independently represents hydrogen or straightchain alkyl of from 1 to 6, both inclusive, carbon atoms; G'' represents hydrogen or acetyl; R represents hydrogen or alkyl of from 1 to 6, both inclusive, carbon atoms; R'' represents halo, alkoxy containing from 1 to 6, both inclusive, carbon atoms in the alkyl group, hydrogen or alkyl of from 1 to 6, both inclusive, carbon atoms; each R'''' independently represents hydrogen or alkyl of from 1 to 6, both inclusive, carbon atoms; each R'''''' independently represents hydrogen or alkyl of from 1 to 6, both inclusive, carbon atoms, or both R'''''' groups taken together represent oxo( O); X represents halo; and each n independently represents an integer of from 0 to 1, both inclusive. The terms ''''halo'''' and ''''halide'''' are employed herein to designate occurrences of bromine, chlorine, and iodine. The adamantane compounds of formulae VII and VIII are useful as agents to achieve a depressant action on the central nervous system of warm blooded animals. The adamantane compounds of Formulae I, II, III, IV, V and VI are useful as intermediates in the synthesis of the compounds of Formulae VII and VIII.